Patents by Inventor Szeman CHAN

Szeman CHAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Materials and methods of using engineered ligands
    Patent number: 11952411
    Abstract: Described herein are compositions and kits that comprise an engineered TL1A ligand that displays high stability, minimal binding to decoy receptor DcR3 while retaining functional activity via binding to its cell surface receptor, DR3, and the ability to activate T cells in vitro and in vivo. Methods of making an engineered TL1A ligand and methods of treating a disease or disorder in a subject by administering an engineered TL1A ligand are also provided.
    Type: Grant
    Filed: August 18, 2021
    Date of Patent: April 9, 2024
    Assignee: Janssen Biotech, Inc.
    Inventors: Adam Zwolak, Szeman Chan, Rajkumar Ganesan
  • MATERIALS AND METHODS OF USING ENGINEERED LIGANDS
    Publication number: 20220056104
    Abstract: Described herein are compositions and kits that comprise an engineered TL1A ligand that displays high stability, minimal binding to decoy receptor DcR3 while retaining functional activity via binding to its cell surface receptor, DR3, and the ability to activate T cells in vitro and in vivo. Methods of making an engineered TL1A ligand and methods of treating a disease or disorder in a subject by administering an engineered TL1A ligand are also provided.
    Type: Application
    Filed: August 18, 2021
    Publication date: February 24, 2022
    Applicant: JANSSEN BIOTECH, INC.
    Inventors: Adam ZWOLAK, Szeman CHAN, Rajkumar GANESAN