Abstract: The invention, in some aspects, relates to methods for diagnosing cardiovascular disease, and/or detecting cardiovascular disease in a patient, and more particularly to methods of using blood-based biomarkers and their combinations to identify patients at risk of having cardiovascular disease (e.g., coronary atherosclerosis).

Abstract: The invention, in some aspects, relates to methods for evaluating a human subject for having atherosclerotic coronary artery disease (ASCAD) or as having a coronary atherosclerotic plaque. In some aspects, the invention relates to methods and kits useful for diagnosing, classifying, profiling and treating atherosclerotic CAD and or a coronary atherosclerotic plaque.

Abstract: The invention, in some aspects, relates to methods for diagnosing cardiovascular disease, and/or detecting cardiovascular disease in a patient, and more particularly to methods of using blood-based biomarkers and their combinations to identify patients at risk of having cardiovascular disease (e.g., coronary atherosclerosis).

Abstract: The invention, in some aspects, relates to methods for evaluating a human subject for having atherosclerotic coronary artery disease (ASCAD) or as having a coronary atherosclerotic plaque. In some aspects, the invention relates to methods and kits useful for diagnosing, classifying, profiling and treating atherosclerotic CAD and or a coronary atherosclerotic plaque.

Abstract: The invention, in some aspects, relates to methods for evaluating a human subject for having atherosclerotic coronary artery disease (ASCAD) or as having a coronary atherosclerotic plaque. In some aspects, the invention relates to methods and kits useful for diagnosing, classifying, profiling and treating atherosclerotic CAD and or a coronary atherosclerotic plaque.

Abstract: Methods and systems utilizing the data provided by a non-contrast-enhanced CAC scan that is left unused by the “whole-heart” Agatston or volume scores. Agatston and volume scores summarize overall coronary calcium burden, but do not show the number of vessels involved, the geographic distribution of the lesions, the size and shape of the individual lesions and the distance of the lesions from the coronary ostium. The methods and systems described herein extract and use the enhanced information provided by 3-D CAC scan data and significantly increases its clinical predictive value by providing vessel and lesion specific CAC scores which are superior to the whole-heart Agatston and volume scores in predicting obstructive Coronary artery disease (CAD).

Abstract: A method for generating a report presenting a patient-specific information relevant to assessing a patient's cardiodiabetes risk to guide and allow a physician or healthcare provider in the choice of therapy or therapies that will be maximally effective for a specific patient, to monitor the response to the chosen therapy and reduce the patient's risk of developing cardiodiabetes and/or its complications.

Abstract: Methods and systems utilizing the data provided by a non-contrast-enhanced CAC scan that is left unused by the “whole-heart” Agatston or volume scores. Agatston and volume scores summarize overall coronary calcium burden, but do not show the number of vessels involved, the geographic distribution of the lesions, the size and shape of the individual lesions and the distance of the lesions from the coronary ostium. The methods and systems described herein extract and use the enhanced information provided by 3-D CAC scan data and significantly increases its clinical predictive value by providing vessel and lesion specific CAC scores which are superior to the whole-heart Agatston and volume scores in predicting obstructive Coronary artery disease (CAD).

Abstract: The present invention is directed to methods for atherosclerosis risk reduction including initial risk stratification, goal setting, and goal attainment for patients with, or at risk for, atherosclerosis. The present invention may be embodied in a computer implemented software product, the modules and sub-routines resident on a computer or hand held device, allowing a physician to determine the best strategy for coronary artery disease prevention based on such risk assessment values as Framingham score, genetic predisposition, biomarker levels and atherosclerosis imaging scores. The software product is supported by a backend database containing risk assessment value scores for a patient population of known clinical outcome. The database may reside in a memory unit, such as a hard drive, of the computer or hand held device, or may be accessed remotely in a distributed computer environment.