Patents by Inventor Szofia Bullain

Szofia Bullain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHIMERIC T-CELL RECEPTORS AND T-CELLS TARGETING EGFRVIII ON TUMORS
    Publication number: 20100105136
    Abstract: Chimeric T-cell receptor proteins have been produced in cells by the construction of nucleic acids and vectors, and the transfection of the vectors into cells. The chimeric proteins comprise, as an extracellular binding portion, a single chain antibody portion that binds to EGFRvIII, a transmembrane portion derived from human CD8? or CD28, and an intracellular signaling portion derived from human CD3?. The invention includes nucleic acids, vectors and cells associated with the production of the chimeric membrane protein, as well as methods to treat rumors bearing EGFRvIII, a mutant epidermal growth factor receptor.
    Type: Application
    Filed: October 9, 2007
    Publication date: April 29, 2010
    Applicants: The General Hospital Corporation, Children's Medical Center Corporation
    Inventors: Bob S. Carter, Richard C. Mulligan, Szofia Bullain