Patents by Inventor Szu-Yao Kuo

Szu-Yao Kuo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide-conjugates that bind to VEGF-stimulated or tumor vasculature and methods of treatment
    Patent number: 8088887
    Abstract: The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovasculature and were identified by in vivo phage display. One such peptide, SP5-52, recognized the neovasculature of multiple tumors in SCID mice, but did not target normal blood vessels. This peptide also binds to blood vessels of human lung cancer biopsy specimens. Liposomes comprising SP5-52 and doxorubicin enhanced the efficacy of the drug against multiple human cancer xenografts in SCID mice.
    Type: Grant
    Filed: April 13, 2007
    Date of Patent: January 3, 2012
    Assignees: Academia Sinica, National Taiwan University
    Inventors: Han-Chung Wu, Chin-Tarng Lin, Tong-Young Lee, Szu-Yao Kuo
  • Peptides that target to tumor blood vessels of lung cancer and applications thereof
    Publication number: 20080193510
    Abstract: The invention provides nucleic acids, peptides, and antibodies for use in applications including diagnosis and therapy. The peptides target neovasculature and were identified by in vivo phage display. One such peptide, SP5-52, recognized the neovasculature of multiple tumors in SCID mice, but did not target normal blood vessels. This peptide also binds to blood vessels of human lung cancer biopsy specimens. Liposomes comprising SP5-52 and doxorubicin enhanced the efficacy of the drug against multiple human cancer xenografts in SCID mice.
    Type: Application
    Filed: April 13, 2007
    Publication date: August 14, 2008
    Inventors: Han-Chung Wu, Chin-Tarng Lin, Tong-Young Lee, Szu-Yao Kuo