Patents by Inventor T. C. Wu

T. C. Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions comprising albumin-FMS-like tyrosine kinase 3 ligand fusion proteins and uses thereof
    Patent number: 11246908
    Abstract: The present invention provides a novel fusion protein of Flt3L and albumin and its use to increase the Flt3L half-life in vivo and to deliver Flt3L to immune cells in a subject to enhance alternative dendritic cell populations. Use of the fusion protein in combination with other chemotherapeutic, radiotherapeutic and immunotherapeutic methods are also provided.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: February 15, 2022
    Assignee: The Johns Hopkins University
    Inventors: T. C. Wu, Chien-Fu Hung, Brandon Krishna Lam
  • Compositions and methods for rendering tumor cells susceptible to CD8+ T cell-mediated killing
    Patent number: 10183985
    Abstract: The present invention provides an immunoconjugate having the formula: T-c-En-c-Fcn or T-c-Fcn-c-En; wherein, T is a single chain variable portion fragment of a monoclonal antibody (scFv) directed to a target protein, polypeptide, or fragment thereof, which is highly expressed on cancer cells; E is two or more foreign immunogenic CD8+ T cell antigenic epitopes; c is a peptide or polypeptide fragment thereof, capable of being cleaved by a specific protease; and Fc is two or more Fc portions of an IgG antibody. Nucleic acid sequences encoding the same and vectors containing said nucleic acid sequences are also provided. Methods of making the immunoconjugate, along with methods of making target cells susceptible to CTL mediated cell killing, and methods for treatment of cancers are also provided.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: January 22, 2019
    Assignee: The Johns Hopkins University
    Inventors: Chien-Fu Hung, T. C. Wu
  • Compositions and methods for rendering tumor cells susceptible to CD8+ T cell-mediated killing
    Patent number: 9561275
    Abstract: The present invention provides an immunoconjugate having the formula: T-c-En-c-Fcn or T-c-Fcn-c-En; wherein, T is a single chain variable portion fragment of a monoclonal antibody (scFv) directed to a target protein, polypeptide, or fragment thereof, which is highly expressed on cancer cells; E is two or more foreign immunogenic CD8+ T cell antigenic epitopes; c is a peptide or polypeptide fragment thereof, capable of being cleaved by a specific protease; and Fc is two or more Fc portions of an IgG antibody. Nucleic acid sequences encoding the same and vectors containing said nucleic acid sequences are also provided. Methods of making the immunoconjugate, along with methods of making target cells susceptible to CTL mediated cell killing, and methods for treatment of cancers are also provided.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: February 7, 2017
    Assignee: The Johns Hopkins University
    Inventors: Chien-Fu Hung, T. C. Wu
  • Facsimile apparatus and method for sending and receiving private information
    Patent number: 5351136
    Abstract: A FAX-receiving-and-output device for secret information and method therefore, which comprises a first and a second information transmission channels for transmitting non-secret information and secret information respectively; the second information transmission channel includes a memory for storage of secret information, and a memory for storage of identifying code and memory address of a secret information. To transmit a secret information, the sender first inputs the identifying code of the intended recipient of that information before transmitting that secret information. An identifying module at an receiving terminal would recognize such identifying case, and the secret information will be stored in a memory.
    Type: Grant
    Filed: July 10, 1992
    Date of Patent: September 27, 1994
    Assignee: Industrial Technology Research Institute
    Inventors: T. C. Wu, Ray-Ten Chen, Wen-Pin Chang