Patents by Inventor T. Christian Boles

T. Christian Boles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10473619
    Abstract: The disclosure provides cassettes, electrophoresis systems, methods for making the device, and methods of fractionating a sample using the cassettes and electrophoresis systems described herein.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: November 12, 2019
    Assignee: SAGE SCIENCE, INC.
    Inventors: Douglas Grosvenor Sabin, Joshua Gomes, Todd J. Barbera, Charles Sidoti, Simranjit Singh, T. Christian Boles
  • Publication number: 20190153426
    Abstract: Methods, systems and apparatus for automated extraction, purification, and processing of nucleic acids from biological samples are presented. In some embodiments, hydrogel supports are used to immobilize particulate biological input samples and extract nucleic acids during operations. The use of hydrogel facilitates automated sample processing on robotic liquid handling systems. Devices, methods, and systems are also provided for electrophoretic sample preparation.
    Type: Application
    Filed: November 15, 2018
    Publication date: May 23, 2019
    Applicants: SAGE SCIENCE, INC., SAGE SCIENCE, INC.
    Inventors: Ezra S. ABRAMS, Danny YUN, Todd J. BARBERA, Douglas Grosvenor SABIN, T. Christian BOLES
  • Patent number: 10131901
    Abstract: Methods, systems and apparatus for automated extraction, purification, and processing of nucleic acids from biological samples are presented. In some embodiments, hydrogel supports are used to immobilize particulate biological input samples and extract nucleic acids during operations. The use of hydrogel facilitates automated sample processing on robotic liquid handling systems. Devices, methods, and systems are also provided for electrophoretic sample preparation.
    Type: Grant
    Filed: October 15, 2015
    Date of Patent: November 20, 2018
    Assignee: SAGE SCIENCE, INC.
    Inventors: Ezra S. Abrams, Danny Yun, Todd J. Barbera, Douglas Grosvenor Sabin, T. Christian Boles
  • Publication number: 20170254774
    Abstract: The disclosure provides cassettes, electrophoresis systems, methods for making the device, and methods of fractionating a sample using the cassettes and electrophoresis systems described herein.
    Type: Application
    Filed: March 20, 2017
    Publication date: September 7, 2017
    Inventors: Douglas Grosvenor Sabin, Joshua Gomes, Todd J. Barbera, Charles Sidoti, Simranjit Singh, T. Christian Boles
  • Publication number: 20170240882
    Abstract: Methods, systems and apparatus for automated extraction, purification, and processing of nucleic acids from biological samples are presented. In some embodiments, hydrogel supports are used to immobilize particulate biological input samples and extract nucleic acids during operations. The use of hydrogel facilitates automated sample processing on robotic liquid handling systems. Devices, methods, and systems are also provided for electrophoretic sample preparation.
    Type: Application
    Filed: October 15, 2015
    Publication date: August 24, 2017
    Inventors: Ezra S. ABRAMS, Danny YUN, Todd J. BARBERA, Douglas Grosvenor SABIN, T. Christian BOLES
  • Publication number: 20170239658
    Abstract: In some embodiments, a method for manipulating DNA molecules for use in a microfluidic device is provided, where the method may comprise providing a solution of a plurality of DNA molecules having a first radius of gyration under under a zero flow velocity, and maintaining the DNA molecules in a spherical shape under a flow velocity.
    Type: Application
    Filed: October 16, 2015
    Publication date: August 24, 2017
    Inventors: Ezra S. ABRAMS, T. Christian BOLES, Yu CHEN, James STURM, Robert AUSTIN
  • Patent number: 9719961
    Abstract: The invention provides an electrophoresis cassette, methods for making the electrophoresis cassette, and method of fractionating analytes from a sample based upon electrophoretic mobility in a single application of the sample to an electrophoretic system.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: August 1, 2017
    Assignee: SAGE SCIENCE, INC.
    Inventors: Douglas Grosvenor Sabin, Todd J. Barbera, Paul Chandler Sabin, T. Christian Boles
  • Patent number: 9599590
    Abstract: The disclosure provides cassettes, electrophoresis systems, methods for making the device, and methods of fractionating a sample using the cassettes and electrophoresis systems described herein.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: March 21, 2017
    Assignee: Sage Science, Inc.
    Inventors: Douglas Grosvenor Sabin, Joshua Gomes, Todd J. Barbera, Charles Sidoti, Simranjit Singh, T. Christian Boles
  • Publication number: 20160370318
    Abstract: The invention provides an electrophoresis cassette, methods for making the electrophoresis cassette, and method of fractionating analytes from a sample based upon electrophoretic mobility in a single application of the sample to an electrophoretic system.
    Type: Application
    Filed: June 15, 2016
    Publication date: December 22, 2016
    Inventors: Douglas Grosvenor Sabin, Todd J. Barbera, Paul Chandler Sabin, T. Christian Boles
  • Publication number: 20150166986
    Abstract: Systems and methods for processing fluid samples are disclosed. Fluid sample processing is accomplished using a series of microfluidic bump arrays include an automated and integrated system for sorting particles from a biological sample, lysing those particles to expose total RNA or DNA, purifying the RNA or DNA, processing the RNA or DNA by chemical or enzymatic modification, to select RNA or DNA molecules by size, or to generate, optionally, a sequencing library. The sequencing library is suitable for use in next generation sequencing (“NGS”).
    Type: Application
    Filed: February 23, 2015
    Publication date: June 18, 2015
    Inventors: T. Christian Boles, Ezra Solomon Abrams
  • Patent number: 9012373
    Abstract: Systems and methods for processing fluid samples are disclosed. Fluid sample processing is accomplished using a series of microfluidic bump arrays include an automated and integrated system for sorting particles from a biological sample, lysing those particles to expose total RNA or DNA, purifying the RNA or DNA, processing the RNA or DNA by chemical or enzymatic modification, to select RNA or DNA molecules by size, or to generate, optionally, a sequencing library. The sequencing library is suitable for use in next generation sequencing (“NGS”).
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: April 21, 2015
    Assignee: Sage Science, Inc.
    Inventors: T. Christian Boles, Ezra Solomon Abrams
  • Publication number: 20150101932
    Abstract: The disclosure provides cassettes, electrophoresis systems, methods for making the device, and methods of fractionating a sample using the cassettes and electrophoresis systems described herein.
    Type: Application
    Filed: October 10, 2013
    Publication date: April 16, 2015
    Inventors: Douglas Grosvenor Sabin, Joshua Gomes, Todd J. Barbera, Charles Sidoti, Simranjit Singh, T. Christian Boles
  • Publication number: 20140284213
    Abstract: The invention provides an electrophoresis cassette, methods for making the electrophoresis cassette, and method of fractionating analytes from a sample based upon electrophoretic mobility in a single application of the sample to an electrophoretic system.
    Type: Application
    Filed: June 5, 2014
    Publication date: September 25, 2014
    Inventors: Douglas Grosvenor Sabin, Todd J. Barbera, Paul Chandler Sabin, T. Christian Boles
  • Publication number: 20130240360
    Abstract: The invention provides an electrophoresis cassette, methods for making the electrophoresis cassette, and method of fractionating analytes from a sample based upon electrophoretic mobility in a single application of the sample to an electrophoretic system.
    Type: Application
    Filed: January 28, 2013
    Publication date: September 19, 2013
    Applicant: SAGE SCIENCE, INC.
    Inventors: Douglas Grosvenor Sabin, Todd J. Barbera, Paul Chandler Sabin, T. Christian Boles
  • Publication number: 20130233714
    Abstract: The invention provides an electrophoresis cassette, methods for making the electrophoresis cassette, and method of fractionating analytes from a sample based upon electrophoretic mobility in a single application of the sample to an electrophoretic system.
    Type: Application
    Filed: January 28, 2013
    Publication date: September 12, 2013
    Applicant: SAGE SCIENCE, INC.
    Inventors: Douglas Grosvenor Sabin, Todd J. Barbera, Paul Chandler Sabin, T. Christian Boles
  • Publication number: 20130079251
    Abstract: Systems and methods for processing fluid samples are disclosed. Fluid sample processing is accomplished using a series of microfluidic bump arrays include an automated and integrated system for sorting particles from a biological sample, lysing those particles to expose total RNA or DNA, purifying the RNA or DNA, processing the RNA or DNA by chemical or enzymatic modification, to select RNA or DNA molecules by size, or to generate, optionally, a sequencing library. The sequencing library is suitable for use in next generation sequencing (“NGS”).
    Type: Application
    Filed: August 3, 2012
    Publication date: March 28, 2013
    Applicant: Sage Science, Inc.
    Inventor: T. Christian Boles
  • Patent number: 8361299
    Abstract: The invention provides an electrophoresis cassette, methods for making the electrophoresis cassette, and method of fractionating analytes from a sample based upon electrophoretic mobility in a single application of the sample to an electrophoretic system.
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: January 29, 2013
    Assignee: Sage Science, Inc.
    Inventors: Douglas Grosvenor Sabin, Todd J Barbera, Paul Chandler Sabin, T. Christian Boles
  • Patent number: 8361298
    Abstract: The invention provides an electrophoresis cassette, methods for making the electrophoresis cassette, and method of fractionating analytes from a sample based upon electrophoretic mobility in a single application of the sample to an electrophoretic system.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: January 29, 2013
    Assignee: Sage Science, Inc.
    Inventors: Douglas G. Sabin, Todd J. Barbera, Paul Chandler Sabin, T. Christian Boles
  • Publication number: 20110062024
    Abstract: The invention provides an electrophoresis cassette, methods for making the electrophoresis cassette, and method of fractionating analytes from a sample based upon electrophoretic mobility in a single application of the sample to an electrophoretic system.
    Type: Application
    Filed: April 14, 2010
    Publication date: March 17, 2011
    Inventors: Douglas Grosvenor Sabin, Todd J. Barbera, Paul Chandler Sabin, T. Christian Boles
  • Publication number: 20100126862
    Abstract: The invention provides an electrophoresis cassette, methods for making the electrophoresis cassette, and method of fractionating analytes from a sample based upon electrophoretic mobility in a single application of the sample to an electrophoretic system.
    Type: Application
    Filed: October 8, 2009
    Publication date: May 27, 2010
    Applicant: Sage Science, Inc.
    Inventors: Douglas G. Sabin, Todd J. Barbera, Paul Chandler Sabin, T. Christian Boles