Abstract: A process for making a latex emulsion suitable for use in a toner composition includes contacting a resin with a solid neutralizing agent in the absence of an organic solvent to form a mixture either via a co-feeding process or a pre-blend mixture, and adding a solid or aqueous surfactant to the pre-blend mixture or prior to melt mixing the mixture.

Abstract: Various solvent-assisted extrusion processes are disclosed that are suitable for forming high yield, low coarse content, polyester latexes that may be utilized in forming a toner.

Abstract: The present invention is directed to compounds of formulae (I) and (II) and pharmaceutically acceptable forms thereof; pharmaceutical compositions thereof; and methods of treating a viral infection, such as a hepatitis C virus (HCV) infection, by administering to a subject diagnosed with or being susceptible to the viral infection a compound of formulae (I) and (II), a pharmaceutically acceptable form thereof, or a pharmaceutical composition thereof. The present invention is also directed to high-throughput methods of identifying compounds able to modulate hepatitis C virus (HCV) replication activity.

Abstract: The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular methods of using agonists and antagonists of TGF-? superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.

Abstract: The present invention is directed, in part, to methods and compositions comprising inhibitors of micro RNA-145 and activators of the TGF-? signaling pathway to permit reprogramming using only small molecule compounds. Also described herein are methods to distinguish cancer cells or cells having cancerous potential in human iPS cell populations, based on determining the balance of p21-p53 expression levels, or ratio thereof in reprogrammed cells. In further aspects, methods and compositions to cause redifferentiation of a hepatoma cell to a hepatocye-like cell using acyclic retinoid and inhibitors of AKR1B10 are provided.

Abstract: A method includes forming a winding structure from a single sheet of electrically conductive material, where the winding structure includes a winding base and multiple winding extensions extending from the winding base as a continuous piece of the electrically conductive material. The multiple winding extensions include a base portion that extends from the winding base along a first face of a fully assembled magnetic core, a wrapping portion that extends from the base portion along a second face of the fully assembled magnetic core, and a connection portion that extends from the wrapping portion along a third face of the fully assembled magnetic core, the connection portion comprising an electrical connection surface. The base portion, the wrapping portion, and the connection portion of each winding extend from the winding base such that the integrated windin structure is shaped for placement over the full assembled magnetic core in a single motion.

Abstract: The invention relates to methods of treatment of hepatitis C, dyslipidemia, insulin resistance, and inflammation, with flavonoid-sugar complexes.

Abstract: Various solvent-assisted extrusion processes are disclosed that are suitable for forming high yield, low coarse content, polyester latexes that may be utilized in forming a toner.

Abstract: A screw extruder is presented including a feed hopper for receiving materials and a body member having at least one supply port and at least one outlet port. The screw extruder also includes a screw positioned within the body member and movable along a channel defining a longitudinal axis. The screw extruder further includes a drive shaft for rotatably driving the screw along the channel. The screw extruder may be configured to mix the materials received via the feed hopper with a series of one or more forward, neutral, and reverse kneading elements.

Abstract: An apparatus, system, and method are disclosed for a low cost multiple output redundant power supply. Disclosed is a power supply that includes a primary stage for regulating voltage on an internal bus. The power supply includes a first regulator stage and a second regulator stage connected to the internal bus. The first regulator stage regulates voltage on a bus configured to connect to a first system. The second regulator stage regulates voltage on a bus configured to connect to a second system. The each regulator stage continues to operate in the event the other regulator stage is not operating. A disconnecting means is connected between the primary stage and the each regulator stage for isolating the failed regulator stage from the other regulator stage and the primary stage.

Abstract: According to one embodiment, a circuit for providing redundant power includes a first channel having a first input, a first electronic circuit breaker, and a first output, a second channel having a second input, a second electronic circuit breaker, and a second output, and a first transistor coupled to the first electronic circuit breaker, the first transistor in series with a second transistor coupled to the second channel. The circuit normally operates by providing power to the first and second outputs from the first and second channels, respectively. However, if the first channel fails, the transistors switch on to allow power from the second channel to feed the first output in the first channel in addition to feeding power to the second output, and vice versa. Other embodiments and methods for providing redundant power are described as well.

Abstract: An apparatus, system, and method are disclosed for combining multiple windings on a magnetic core. An integrated winding structure has a winding base and multiple winding extensions. The multiple winding extensions and the winding base are formed from a single sheet of electrically conductive material. Each of the multiple winding extensions has a base portion that extends from the winding base, a wrapping portion that extends from the base portion, and a connection portion that extends from the wrapping portion. The connection portions and the winding base each have electrical connection surfaces. Each of the multiple winding extensions forms one or more windings on the magnetic core.

Abstract: An apparatus, system, and method are disclosed for combining multiple windings on a magnetic core. An integrated winding structure has a winding base and multiple winding extensions. The multiple winding extensions and the winding base are formed from a single sheet of electrically conductive material. Each of the multiple winding extensions has a base portion that extends from the winding base, a wrapping portion that extends from the base portion, and a connection portion that extends from the wrapping portion. The connection portions and the winding base each have electrical connection surfaces. Each of the multiple winding extensions forms one or more windings on the magnetic core.

Abstract: A process for making a latex emulsion suitable for use in a toner composition includes contacting at least one amorphous polyester resin with a viscosity reducing additive in the absence of an organic solvent to form a resin mixture either via an extruder or batch process, and adding a surfactant, neutralizing agent, and deionized water to the resin mixture.

Abstract: The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-? superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.

Abstract: A process for making a latex emulsion suitable for use in a toner composition includes contacting a resin with a solid neutralizing agent in the absence of an organic solvent to form a mixture either via a co-feeding process or a pre-blend mixture, and adding a solid or aqueous surfactant to the pre-blend mixture or prior to melt mixing the mixture.

Abstract: A process for making a self-emulsifying granule suitable for use in forming latex emulsions includes contacting a resin with a solid or highly concentrated surfactant, a solid neutralization agent and water in the absence of an organic solvent to form a mixture, melt mixing the mixture, and forming self-emulsifying granules of the melt mixed mixture. Self-emulsifying granules are also provided and configured to form a latex emulsion when added to water.

Abstract: A process for making a self-emulsifying granule suitable for use in forming latex emulsions includes contacting a resin with a solid or highly concentrated surfactant, a solid neutralization agent and water in the absence of an organic solvent to form a mixture, melt mixing the mixture, and forming self-emulsifying granules of the melt mixed mixture. Self-emulsifying granules are also provided and configured to form a latex emulsion when added to water, which may then be utilized to form a toner.

Abstract: A process for making a self-emulsifying composite suitable for use in forming latex emulsions includes contacting a resin with a solid or highly concentrated surfactant, a solid neutralizing agent in the absence of water and an organic solvent to form a mixture, melt mixing the mixture, and forming a self-emulsifying composite of the melt mixed mixture such as a granule. Self-emulsifying granules are also provided and configured to form a latex emulsion when added to water, which may then be utilized to form a toner.

Abstract: An apparatus, system, and method are disclosed for safely connecting a device to a power source. The invention includes a power bus switch that operates to selectively allow operational power to flow from a power supply to a load. The operational power is independent of auxiliary power which may be separately provided to the load. A detection module determines whether an input impedance of the load is greater than a minimum impedance threshold in response to the load being connected to the power supply. A switch module causes the power bus switch to allow operational power to flow to the load in response to the detection module determining that the input impedance is greater than the minimum impedance threshold. Thus, if the load has an acceptable input impedance level, then operational power may be provided to the load without risk of failure to the power system.