Abstract: The present invention discloses novel cholinergic receptor ligands. The present invention also relates to the synthesis of substituted derivatives of aza-bridged bicyclic amines for use as muscarinic receptor ligands as well as methods of regulating function of certain cholinergic receptors, and hence acting as antagonists, agonists and partial agonists at certain specific cholinergic receptor subtypes. The present invention also relates to methods for treating disorders associated with cholinergic receptors.

Abstract: A tool for axially removing a defect-containing length portion from a steam generator tubesheet primary side grips the tube length portion on both sides of the defect by radially outwardly moving gripper structure in the form of expanding ferrules (16,20) or collet spring fingers (60). Structure in the form of a central mandrel member (12, 13 or 50, 52, 54) moves axially to actuate the gripper structure. A sleeve (62) separately actuated on the mandrel (50) assists this action in the collet spring finger (60) embodiment. Movement of the defect-containing length portion requires an initial cutting of the tube-to-tubesheet weld, and for convenience, separation of the tube length portion from the remainder of the tube. Hydraulic structure (32, 56, 64) provides the motion axially of the grippers' actuators (14, 22, 23 or 58, 66) on either side of the defect either independently or together.

Abstract: A wheeled transporter is placed at the periphery of the tube bundle which extends up from its tube sheet within a nuclear steam generator shell. The transporter is formed in hinged sections which can be disengaged as required at the periphery of the tube bundle. A cable attached to each end of the transporter extend through the handholes for movement of the transporter along the bundle periphery. Pistons on the transporter are controlled remotely to extend into engagement with the internal wall of the generator shell to selectively immobilize the transporter at any desired peripheral position and thereby form a steady base for maintenance and inspection devices mounted on the transporter.