Abstract: Disclosed herein are heterocyclic compounds that inhibit the binding of menin and MLL or MLL fusion proteins. Also described are specific irreversible inhibitors of menin-MLL interaction. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the menin-MLL irreversible inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, leukemia and other diseases or conditions dependent on menin-MLL interaction.

Abstract: Methods and systems of using a trained machine-learning model to perform root cause analysis on a manufacturing process. A pre-trained machine learning model is provided that is trained to predict measurements of non-faulty parts. The pre-trained model is trained on training measurement data regarding physical characteristics of manufactured parts as measured by a plurality of sensors at a plurality of manufacturing stations. With the trained model, then measurement data from the sensors is received regarding the manufactured part and the stations. This new set of measurement data is back propagated through the pre-trained model to determine a magnitude of absolute gradients of the new measurement data. The root cause is then identified based on this magnitude of absolute gradients. In other embodiments the root cause is identified based on losses determined between a set of predicted measurement data of a part using the model, and actual measurement data.

Abstract: Disclosed herein are heterocyclic compounds, for example, according to the following formula and analogs thereof: that inhibit the activity of FLT3. Also described are specific covalent inhibitors of FLT3. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the FLT3 inhibitors are disclosed, alone or in combination with other therapeutic agents, for the treatment of proliferative diseases or conditions, including hematological malignancies and other diseases or conditions dependent on FLT3 activity.

Abstract: Embodiments provide mechanisms to facilitate compute operations for deep neural networks. One embodiment comprises a graphics processing unit comprising one or more multiprocessors, at least one of the one or more multiprocessors including a register file to store a plurality of different types of operands and a plurality of processing cores. The plurality of processing cores includes a first set of processing cores of a first type and a second set of processing cores of a second type. The first set of processing cores are associated with a first memory channel and the second set of processing cores are associated with a second memory channel.

Abstract: In one aspect, the present disclosure provides GlcNAc-Asn analogs of the formula: wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of using the compounds disclosed herein. Additionally, the present disclosure also provides methods of treating cancer comprising inhibiting NGLY1.

Abstract: In one aspect, the present disclosure provides GlcNAc-Asn analogs of the formula (I): wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of using the compounds disclosed herein. Additionally, the present disclosure also provides methods of treating cancer comprising inhibiting NGLY1.

Abstract: A 2-phase bipolar step motor has a rotor and a stator, the rotor having a plurality of equally spaced rotor poles of alternating north and south magnetic polarities, and the stator having at least eight stator poles extending radially from a stator yoke and terminating in pole shoes interacting radially across an air gap with the rotor poles to cause the rotor to rotate step-by-step when windings around the stator poles are driven by a succession of energized states of the stator. The stator poles divided into four equal groups having a specified drive phase A or B, adjacent poles of a group having alternating drive polarities of the same drive phase A and ?, or B and B. Adjacent poles in the same group are separated by a center-to-center angle one-half of the rotor tooth pitch or up to 20% larger. Adjacent poles of different groups have a larger separation than that between poles of the same group.

Abstract: A two-phase bipolar step motor, comprises a rotor having a plurality of pairs of rotor poles of alternating magnetic polarity, and a stator having four primary energizable stator poles with conductive windings around those primary stator poles and four passive inter-poles located uniformly between every adjacent pair of primary stator poles, the passive inter-poles lacking any conductive windings. Both 18° steppers with five pairs of rotor poles and 30° steppers with three pairs of rotor poles are provided. Also provided are both PM hybrid mix steppers with 2D magnetic flux paths and hybrid steppers with 3D magnetic flux paths having an axial component. In each case, the overall lengths of the flux paths are substantially reduced from conventional designs resulting in improved motor efficiency.

Abstract: A two-phase bipolar step motor, comprises a rotor having a plurality of pairs of rotor poles of alternating magnetic polarity, and a stator having four primary energizable stator poles with conductive windings around those primary stator poles and four passive inter-poles located uniformly between every adjacent pair of primary stator poles, the passive inter-poles lacking any conductive windings. Both 18° steppers with five pairs of rotor poles and 30° steppers with three pairs of rotor poles are provided. Also provided are both PM hybrid mix steppers with 2D magnetic flux paths and hybrid steppers with 3D magnetic flux paths having an axial component. In each case, the overall lengths of the flux paths are substantially reduced from conventional designs resulting in improved motor efficiency.

Abstract: The present disclosure provides a minimally invasive spinal annulus fibrosus repairing device, including at least one bone anchor, at least one annulus fibrosus anchor, and at least one suture. The minimally invasive spinal annulus fibrosus repairing device of the present disclosure can be used to repair the annulus fibrosus damage, and can be combined with the use of an annulus fibrosus implant to repair the damaged annulus fibrosus.

Abstract: A variable reluctance stepper motor comprises a stator and a rotor that is rotatable relative to the stator. The stator comprises an annular outer yoke with a set of circumferentially spaced stator poles at equal angular intervals around the yoke extending radially inward from first portions of the yoke toward the rotor. Phase windings are individually coiled around each of the respective stator poles. Multiple slots are formed in an outer perimeter edge of the yoke at second portions thereof circumferentially situated between the first portions. A permanent magnet is embedded within each slot with circumferentially directed magnetic orientation of the respective permanent magnets. The remote placement of the magnets ensure that detent torque is kept to a minimum, while also increasing holding and dynamic torque levels.

Abstract: A two-phase bipolar step motor, comprises a rotor having a plurality of pairs of rotor poles of alternating magnetic polarity, and a stator having four primary energizable stator poles with conductive windings around those primary stator poles and four passive inter-poles located uniformly between every adjacent pair of primary stator poles, the passive inter-poles lacking any conductive windings. Both 18° steppers with five pairs of rotor poles and 30° steppers with three pairs of rotor poles are provided. Also provided are both PM hybrid mix steppers with 2D magnetic flux paths and hybrid steppers with 3D magnetic flux paths having an axial component. In each case, the overall lengths of the flux paths are substantially reduced from conventional designs resulting in improved motor efficiency.

Abstract: A linear stepping motor has a linear stator and a rod movable longitudinally within the stator. The rod has alternating permanent magnets and spacer disks, successive magnets being N-S opposed. A rod pitch equals twice the magnet width plus twice the disk width. The stator has a stack of stator groups associated with the drive phases. Each stator group is a pair of stator poles of opposite magnetic polarity separated by one-half rod pitch. Adjacent poles in different groups are separated by a [(n+1)/2n] rod pitch, where n is the number of drive phases. Each pole may be an annular disk yoke with a plurality of inward projecting salient pole pieces terminating in pole shoes. Conductive windings for a stator group proceed successively around each pole piece in one direction for a first pole of the group and then successively in a reverse direction for a second pole of the group.

Abstract: A 2-phase bipolar step motor has a rotor and a stator, the rotor having a plurality of equally spaced rotor poles of alternating north and south magnetic polarities, and the stator having at least eight stator poles extending radially from a stator yoke and terminating in pole shoes interacting radially across an air gap with the rotor poles to cause the rotor to rotate step-by-step when windings around the stator poles are driven by a succession of energized states of the stator. The stator poles divided into four equal groups having a specified drive phase A or B, adjacent poles of a group having alternating drive polarities of the same drive phase A and ?, or B and B. Adjacent poles in the same group are separated by a center-to-center angle one-half of the rotor tooth pitch or up to 20% larger. Adjacent poles of different groups have a larger separation than that between poles of the same group.

Abstract: A two-phase stepper motor with a permanent magnet (PM) rotor and a modified hybrid-type stator is provided. The modified hybrid stator can be manufactured even at the smaller motor size because it employs shoeless, straight stator poles without stator teeth and with bobbin coils that are pre-wound outside the motor and easily inserted over each of the stator poles. Each bobbin may be an elongated continuous belt of insulative material with a hollow interior that forms a sleeve that fits around its corresponding stator pole. Conductive wire wound around the sleeve forms the stator coils. Edges of the sleeve may have exterior flanges at radially inner and outer ends of the stator pole to hold windings in place and keep the sleeve from bowing outward. This stator construction allows the motor to be miniaturized so that the PM rotors can be 13 mm diameter or less.

Abstract: A variable reluctance stepper motor comprises a stator and a rotor that is rotatable relative to the stator. The stator comprises an annular outer yoke with a set of circumferentially spaced stator poles at equal angular intervals around the yoke extending radially inward from first portions of the yoke toward the rotor. Phase windings are individually coiled around each of the respective stator poles. Multiple slots are formed in an outer perimeter edge of the yoke at second portions thereof circumferentially situated between the first portions. A permanent magnet is embedded within each slot with circumferentially directed magnetic orientation of the respective permanent magnets. The remote placement of the magnets ensure that detent torque is kept to a minimum, while also increasing holding and dynamic torque levels.

Abstract: A miniature step motor is constructed with a permanent magnet rotor and a hybrid stator assembly. The rotor, mounted for rotation on an axial shaft, has one or more rotor sections or pieces with a pair of magnetic poles on opposed circumferential surfaces of each piece. The stator assembly, with an inner diameter to receive the rotor, is formed from a stack of bipolar phase-stators positioned in different axial planes, each phase-stator interacting with a rotor section via a two-dimensional magnetic flux path that is independent of every other phase-stator in the stack. The at least one rotor section and the phase-stators have different amounts of rotor-stator rotational offsets at specified angles 180°/N relative to each other about the axial shaft, where N is the number of motor phases. The phase-stators can be mutually offset from one another, or the rotor sections can be mutually offset.

Abstract: The present technology addresses a need for a task service that can aggregate tasks assigned to a user on different services so that all tasks that the user needs to perform can be found in one location. The present technology can utilize credentials to a user account associated with a user of a service to automatically identify tasks that are relevant to the user and can create those tasks in a task service. The task service can maintain a link back to the source of the task so that the user can mark the task as complete in the task service, and the task service can automatically update the task in the service in which the task was created. The present technology can also provide integrations with some services to a user to create new tasks from services that are not task based, such as email.

Abstract: In one aspect, the present disclosure provides GlcNAc-Asn analogs of the formula (I): wherein the variables are as defined herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of using the compounds disclosed herein. Additionally, the present disclosure also provides methods of treating cancer comprising inhibiting NGLY1.

Abstract: A step motor that provides reduced detent torque while maintaining adequate holding torque is characterized by a rotor that includes an annular ring of soft magnetic material (such as medium carbon steel) that surrounds the outer diameter of the rotor permanent magnet and is sandwiched by magnetic insulators of specified axial thickness. This provides a path within the rotor for flux from the permanent magnet in those areas where the radially adjacent stator poles are unenergized, but the magnetic flux can be pulled out by the ampere-turns of energized stator poles.