Patents by Inventor T. Mark McCleskey
T. Mark McCleskey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10877035Abstract: X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical. For estimating the binding selectivities of a chemical versus chemical analogs, for measuring post translational modification of proteins, and for drug manufacturing.Type: GrantFiled: April 22, 2015Date of Patent: December 29, 2020Assignee: ICAGEN, LLCInventors: Eva R. Birnbaum, Andrew T. Koppisch, Sharon M. Baldwin, Benjamin P. Warner, T. Mark McCleskey, Jennifer A. Berger, Jeffrey J. Stewart, Michael N. Harris, Anthony K. Burrell
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Publication number: 20150309021Abstract: X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical. For estimating the binding selectivities of a chemical versus chemical analogs, for measuring post translational modification of proteins, and for drug manufacturing.Type: ApplicationFiled: April 22, 2015Publication date: October 29, 2015Inventors: Eva R. Birnbaum, Andrew T. Koppisch, Sharon M. Baldwin, Benjamin P. Warner, T. Mark McCleskey, Jennifer A. Berger, Jeffrey J. Stewart, Michael N. Harris, Anthony K. Burrell
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Patent number: 9157875Abstract: X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing.Type: GrantFiled: June 29, 2004Date of Patent: October 13, 2015Inventors: Benjamin P. Warner, T. Mark McCleskey, Anthony K. Burrell
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Patent number: 7781589Abstract: A method of determining beryllium or a beryllium compound thereof in a sample, includes providing a sample suspected of comprising beryllium or a compound thereof, extracting beryllium or a compound thereof from the sample by dissolving in a solution, adding a fluorescent indicator to the solution to thereby bind any beryllium or a compound thereof to the fluorescent indicator, and determining the presence or amount of any beryllium or a compound thereof in the sample by measuring fluorescence.Type: GrantFiled: October 31, 2006Date of Patent: August 24, 2010Assignee: Los Alamos National Security, LLCInventors: T. Mark McCleskey, Deborah S. Ehler, Kevin D. John, Anthony K. Burrell, Gavin E. Collis, Edel M. Minogue, Benjamin P. Warner
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Patent number: 7763186Abstract: Substantially pure ionic liquids and ionic liquid precursors were prepared. The substantially pure ionic liquid precursors were used to prepare substantially pure ionic liquids.Type: GrantFiled: December 22, 2006Date of Patent: July 27, 2010Assignee: Los Alamos National Security, LLCInventors: Anthony K. Burrell, Benjamin P. Warner, T. Mark McCleskey, Anoop Agrawal
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Patent number: 7651633Abstract: Nanophosphor compositions were prepared. The compositions can be used for radiation detection.Type: GrantFiled: March 27, 2007Date of Patent: January 26, 2010Assignee: Los Alamos National Security, LLCInventors: Anthony K. Burrell, Kevin C. Ott, John C. Gordon, Rico E. Del Sesto, T. Mark McCleskey
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Patent number: 7633669Abstract: Electrolyte solutions for electrochromic devices such as rear view mirrors and displays with low leakage currents are prepared using inexpensive, low conductivity conductors. Preferred electrolytes include bifunctional redox dyes and molten salt solvents with enhanced stability toward ultraviolet radiation. The solvents include lithium or quaternary ammonium cations, and perfluorinated sulfonylimide anions selected from trifluoromethylsulfonate (CF3SO3?), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N?), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N?) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C?). Electroluminescent, electrochromic and photoelectrochromic devices with nanostructured electrodes include ionic liquids with bifunctional redox dyes. Some of the electrolyte solutions color to red when devices employing the solutions are powered, leading to red or neutral electrooptic devices.Type: GrantFiled: November 6, 2008Date of Patent: December 15, 2009Assignee: Los Alamos National Security, LLCInventors: Anthony K. Burrell, Anoop Agrawal, John P. Cronin, Juan C. L. Tonazzi, Benjamin P. Warner, T. Mark McCleskey
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Patent number: 7615267Abstract: Radiofrequency attenuator and method. The attenuator includes a pair of transparent windows. A chamber between the windows is filled with molten salt. Preferred molten salts include quarternary ammonium cations and fluorine-containing anions such as tetrafluoroborate (BF4?), hexafluorophosphate (PF6?), hexafluoroarsenate (AsF6?), trifluoromethylsulfonate (CF3SO3?), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N?), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N?) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3 C?). Radicals or radical cations may be added to or electrochemically generated in the molten salt to enhance the RF attenuation.Type: GrantFiled: March 28, 2005Date of Patent: November 10, 2009Assignee: Los Alamos National Security, LLCInventors: Benjamin P. Warner, T. Mark McCleskey, Anthony K. Burrell, Anoop Agrawal, Simon B. Hall
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Patent number: 7566569Abstract: The present invention relates to a method for measuring a surface temperature using is a fluorescent temperature sensor or optical thermometer. The sensor includes a solution of 1,3-bis(1-pyrenyl)propane within a 1-butyl-1-1-methyl pyrrolidinium bis(trifluoromethylsulfonyl)imide ionic liquid solvent. The 1,3-bis(1-pyrenyl)propane remains unassociated when in the ground state while in solution. When subjected to UV light, an excited state is produced that exists in equilibrium with an excimer. The position of the equilibrium between the two excited states is temperature dependent.Type: GrantFiled: August 23, 2007Date of Patent: July 28, 2009Assignee: The United States of America as represented by the United States Department of EnergyInventors: Gary A. Baker, Sheila N. Baker, T. Mark McCleskey
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Patent number: 7547888Abstract: A nanocomposite scintillator is prepared using fast, bright, rare-earth doped nanopowder phosphor and a binder that is transparent to the emission of the phosphor.Type: GrantFiled: March 27, 2007Date of Patent: June 16, 2009Assignee: Los Alamos National Security, LLCInventors: D. Wayne Cooke, Edward A. McKigney, Ross E. Muenchausen, Bryan L. Bennett, Kevin C. Ott, Rico E. Del Sesto, T. Mark McCleskey, Anthony K. Burrell
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Publication number: 20090103162Abstract: Electrolyte solutions for electrochromic devices such as rear view mirrors and displays with low leakage currents are prepared using inexpensive, low conductivity conductors. Preferred electrolytes include bifunctional redox dyes and molten salt solvents with enhanced stability toward ultraviolet radiation. The solvents include lithium or quaternary ammonium cations, and perfluorinated sulfonylimide anions selected from trifluoromethylsulfonate (CF3SO3?), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N?), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N?) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C?). Electroluminescent, electrochromic and photoelectrochromic devices with nanostructured electrodes include ionic liquids with bifunctional redox dyes. Some of the electrolyte solutions color to red when devices employing the solutions are powered, leading to red or neutral electrooptic devices.Type: ApplicationFiled: November 6, 2008Publication date: April 23, 2009Inventors: Anthony K. Burrell, Anoop Agrawal, John P. Cronin, Juan C.L. Tonazzi, Benjamin P. Warner, T. Mark McCleskey
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Patent number: 7497993Abstract: The present invention is a fluorescent temperature sensor or optical thermometer. The sensor includes a solution of 1,3-bis(1-pyrenyl)propane within a 1-butyl-1-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide ionic liquid solvent. The 1,3-bis(1-pyrenyl)propane remains unassociated when in the ground state while in solution. When subjected to UV light, an excited state is produced that exists in equilibrium with an excimer. The position of the equilibrium between the two excited states is temperature dependent.Type: GrantFiled: September 7, 2004Date of Patent: March 3, 2009Assignee: The United States of America as represented by the United States Department of EnergyInventors: Gary A. Baker, Sheila N. Baker, T. Mark McCleskey
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Patent number: 7479843Abstract: Radiofrequency attenuator and method. The attenuator includes a pair of transparent windows. A chamber between the windows is filled with molten salt. Preferred molten salts include quarternary ammonium cations and fluorine-containing anions such as tetrafluoroborate (BF4?), hexafluorophosphate (PF6?), hexafluoroarsenate (AsF6?), trifluoromethylsulfonate (CF3SO3?), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N?), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N?) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C?). Radicals or radical cations may be added to or electrochemically generated in the molten salt to enhance the RF attenuation.Type: GrantFiled: November 16, 2004Date of Patent: January 20, 2009Assignee: Los Alamos National Security, LLCInventors: Benjamin P. Warner, T. Mark McCleskey, Anthony K. Burrell, Anoop Agrawal, Simon B. Hall
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Patent number: 7450292Abstract: Electrolyte solutions for electrochromic devices such as rear view mirrors and displays with low leakage currents are prepared using inexpensive, low conductivity conductors. Preferred electrolytes include bifunctional redox dyes and molten salt solvents with enhanced stability toward ultraviolet radiation. The solvents include lithium or quaternary ammonium cations, and perfluorinated sulfonylimide anions selected from trifluoromethylsulfonate (CF3SO3?), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N?), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N?) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C?). Electroluminescent, electrochromic and photoelectrochromic devices with nanostructured electrodes include ionic liquids with bifunctional redox dyes. Some of the electrolyte solutions color to red when devices employing the solutions are powered, leading to red or neutral electrooptic devices.Type: GrantFiled: September 22, 2006Date of Patent: November 11, 2008Assignee: Los Alamos National Security, LLCInventors: Anthony K. Burrell, Anoop Agrawal, John P. Cronin, Juan C. L. Tonazzi, Benjamin P. Warner, T. Mark McCleskey
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Publication number: 20080266642Abstract: Electrolyte solutions for electrochromic devices such as rear view mirrors and displays with low leakage currents are prepared using inexpensive, low conductivity conductors. Preferred electrolytes include bifunctional redox dyes and molten salt solvents with enhanced stability toward ultraviolet radiation. The solvents include lithium or quaternary ammonium cations, and perfluorinated sulfonylimide anions selected from trifluoromethylsulfonate (CF3SO3?), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N?), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N?) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C?). Electroluminescent, electrochromic and photoelectrochromic devices with nanostructured electrodes include ionic liquids with bifunctional redox dyes. Some of the electrolyte solutions color to red when devices employing the solutions are powered, leading to red or neutral electrooptic devices.Type: ApplicationFiled: September 22, 2006Publication date: October 30, 2008Inventors: Anthony K. Burrell, Anoop Agrawal, John P. Cronin, Juan C.L. Tonazzi, Benjamin P. Warner, T. Mark McCleskey
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Publication number: 20080220441Abstract: X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing.Type: ApplicationFiled: October 10, 2007Publication date: September 11, 2008Inventors: Eva R. Birnbaum, Andrew T. Koppisch, Sharon M. Baldwin, Benjamin P. Warner, T. Mark McCleskey, Jeffrey Joseph Stewart, Jennifer A. Berger, Michael N. Harris, Anthony K. Burrell
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Publication number: 20080128624Abstract: A nanocomposite scintillator is prepared using fast, bright, rare-earth doped nanopowder phosphor and a binder that is transparent to the emission of the phosphor.Type: ApplicationFiled: March 27, 2007Publication date: June 5, 2008Inventors: D. Wayne Cooke, Edward A. McKigney, Ross E. Muenchausen, Bryan L. Bennett, Kevin C. Ott, Rico E. Del Sesto, T. Mark McCleskey, Anthony K. Burrell
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Patent number: 7361327Abstract: Novel zeolites are produced by combining a polar solute, a silicon or phosphorous source, and a structure directing agent. Surfactants and a hydrophobic solvent are added to the previously mixed three species and shaken to disperse the surfactants. The reverse microemulsion is stirred overnight, at about room temperature and then iced for five to ten minutes. A metal source is added vigorously shaken for about two minutes. The mixture is then aged for about two hours at about room temperature. A mineralizer is added and the resultant mixture aged for about two hours at about room temperature. The mixture is heated to about 180° C., for a suitable time period. The final novel product is then isolated.Type: GrantFiled: August 17, 2005Date of Patent: April 22, 2008Assignee: Los Alamos National Security, LLCInventors: William Tumas, Kevin C. Ott, T. Mark McCleskey, Matthew Z. Yates, Eva R. Birnbaum
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Patent number: 7317106Abstract: A single-compartment reversible mirror device having a solution of aprotic molten salt, at least one soluble metal-containing species comprising metal capable of being electrodeposited, and at least one anodic compound capable of being oxidized was prepared. The aprotic molten salt is liquid at room temperature and includes lithium and/or quaternary ammonium cations, and anions selected from trifluoromethylsulfonate (CF3SO3?), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N?), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N?) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C?). A method for preparing substantially pure molten salts is also described.Type: GrantFiled: April 22, 2004Date of Patent: January 8, 2008Assignee: Los Alamos National Security, LLCInventors: Benjamin P. Warner, T. Mark McCleskey, Anthony K. Burrell, Simon B. Hall
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Patent number: 7129093Abstract: A method of determining beryllium or a beryllium compound thereof in a sample, includes providing a sample suspected of comprising beryllium or a compound thereof, extracting beryllium or a compound thereof from the sample by dissolving in a solution, adding a fluorescent indicator to the solution to thereby bind any beryllium or a compound thereof to the fluorescent indicator, and determining the presence or amount of any beryllium or a compound thereof in the sample by measuring fluorescence.Type: GrantFiled: March 30, 2004Date of Patent: October 31, 2006Assignee: Los Alamos National Security, LLCInventors: T. Mark McCleskey, Deborah S. Ehler, Kevin D. John, Anthony K. Burrell, Gavin E. Collis, Edel M. Minogue, Benjamin P. Warner