Patents by Inventor T. Mark McCleskey

T. Mark McCleskey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10877035
    Abstract: X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical. For estimating the binding selectivities of a chemical versus chemical analogs, for measuring post translational modification of proteins, and for drug manufacturing.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: December 29, 2020
    Assignee: ICAGEN, LLC
    Inventors: Eva R. Birnbaum, Andrew T. Koppisch, Sharon M. Baldwin, Benjamin P. Warner, T. Mark McCleskey, Jennifer A. Berger, Jeffrey J. Stewart, Michael N. Harris, Anthony K. Burrell
  • Publication number: 20150309021
    Abstract: X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical. For estimating the binding selectivities of a chemical versus chemical analogs, for measuring post translational modification of proteins, and for drug manufacturing.
    Type: Application
    Filed: April 22, 2015
    Publication date: October 29, 2015
    Inventors: Eva R. Birnbaum, Andrew T. Koppisch, Sharon M. Baldwin, Benjamin P. Warner, T. Mark McCleskey, Jennifer A. Berger, Jeffrey J. Stewart, Michael N. Harris, Anthony K. Burrell
  • Patent number: 9157875
    Abstract: X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing.
    Type: Grant
    Filed: June 29, 2004
    Date of Patent: October 13, 2015
    Inventors: Benjamin P. Warner, T. Mark McCleskey, Anthony K. Burrell
  • Patent number: 7781589
    Abstract: A method of determining beryllium or a beryllium compound thereof in a sample, includes providing a sample suspected of comprising beryllium or a compound thereof, extracting beryllium or a compound thereof from the sample by dissolving in a solution, adding a fluorescent indicator to the solution to thereby bind any beryllium or a compound thereof to the fluorescent indicator, and determining the presence or amount of any beryllium or a compound thereof in the sample by measuring fluorescence.
    Type: Grant
    Filed: October 31, 2006
    Date of Patent: August 24, 2010
    Assignee: Los Alamos National Security, LLC
    Inventors: T. Mark McCleskey, Deborah S. Ehler, Kevin D. John, Anthony K. Burrell, Gavin E. Collis, Edel M. Minogue, Benjamin P. Warner
  • Patent number: 7763186
    Abstract: Substantially pure ionic liquids and ionic liquid precursors were prepared. The substantially pure ionic liquid precursors were used to prepare substantially pure ionic liquids.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: July 27, 2010
    Assignee: Los Alamos National Security, LLC
    Inventors: Anthony K. Burrell, Benjamin P. Warner, T. Mark McCleskey, Anoop Agrawal
  • Patent number: 7651633
    Abstract: Nanophosphor compositions were prepared. The compositions can be used for radiation detection.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: January 26, 2010
    Assignee: Los Alamos National Security, LLC
    Inventors: Anthony K. Burrell, Kevin C. Ott, John C. Gordon, Rico E. Del Sesto, T. Mark McCleskey
  • Patent number: 7633669
    Abstract: Electrolyte solutions for electrochromic devices such as rear view mirrors and displays with low leakage currents are prepared using inexpensive, low conductivity conductors. Preferred electrolytes include bifunctional redox dyes and molten salt solvents with enhanced stability toward ultraviolet radiation. The solvents include lithium or quaternary ammonium cations, and perfluorinated sulfonylimide anions selected from trifluoromethylsulfonate (CF3SO3?), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N?), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N?) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C?). Electroluminescent, electrochromic and photoelectrochromic devices with nanostructured electrodes include ionic liquids with bifunctional redox dyes. Some of the electrolyte solutions color to red when devices employing the solutions are powered, leading to red or neutral electrooptic devices.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: December 15, 2009
    Assignee: Los Alamos National Security, LLC
    Inventors: Anthony K. Burrell, Anoop Agrawal, John P. Cronin, Juan C. L. Tonazzi, Benjamin P. Warner, T. Mark McCleskey
  • Patent number: 7615267
    Abstract: Radiofrequency attenuator and method. The attenuator includes a pair of transparent windows. A chamber between the windows is filled with molten salt. Preferred molten salts include quarternary ammonium cations and fluorine-containing anions such as tetrafluoroborate (BF4?), hexafluorophosphate (PF6?), hexafluoroarsenate (AsF6?), trifluoromethylsulfonate (CF3SO3?), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N?), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N?) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3 C?). Radicals or radical cations may be added to or electrochemically generated in the molten salt to enhance the RF attenuation.
    Type: Grant
    Filed: March 28, 2005
    Date of Patent: November 10, 2009
    Assignee: Los Alamos National Security, LLC
    Inventors: Benjamin P. Warner, T. Mark McCleskey, Anthony K. Burrell, Anoop Agrawal, Simon B. Hall
  • Patent number: 7566569
    Abstract: The present invention relates to a method for measuring a surface temperature using is a fluorescent temperature sensor or optical thermometer. The sensor includes a solution of 1,3-bis(1-pyrenyl)propane within a 1-butyl-1-1-methyl pyrrolidinium bis(trifluoromethylsulfonyl)imide ionic liquid solvent. The 1,3-bis(1-pyrenyl)propane remains unassociated when in the ground state while in solution. When subjected to UV light, an excited state is produced that exists in equilibrium with an excimer. The position of the equilibrium between the two excited states is temperature dependent.
    Type: Grant
    Filed: August 23, 2007
    Date of Patent: July 28, 2009
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Gary A. Baker, Sheila N. Baker, T. Mark McCleskey
  • Patent number: 7547888
    Abstract: A nanocomposite scintillator is prepared using fast, bright, rare-earth doped nanopowder phosphor and a binder that is transparent to the emission of the phosphor.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: June 16, 2009
    Assignee: Los Alamos National Security, LLC
    Inventors: D. Wayne Cooke, Edward A. McKigney, Ross E. Muenchausen, Bryan L. Bennett, Kevin C. Ott, Rico E. Del Sesto, T. Mark McCleskey, Anthony K. Burrell
  • Publication number: 20090103162
    Abstract: Electrolyte solutions for electrochromic devices such as rear view mirrors and displays with low leakage currents are prepared using inexpensive, low conductivity conductors. Preferred electrolytes include bifunctional redox dyes and molten salt solvents with enhanced stability toward ultraviolet radiation. The solvents include lithium or quaternary ammonium cations, and perfluorinated sulfonylimide anions selected from trifluoromethylsulfonate (CF3SO3?), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N?), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N?) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C?). Electroluminescent, electrochromic and photoelectrochromic devices with nanostructured electrodes include ionic liquids with bifunctional redox dyes. Some of the electrolyte solutions color to red when devices employing the solutions are powered, leading to red or neutral electrooptic devices.
    Type: Application
    Filed: November 6, 2008
    Publication date: April 23, 2009
    Inventors: Anthony K. Burrell, Anoop Agrawal, John P. Cronin, Juan C.L. Tonazzi, Benjamin P. Warner, T. Mark McCleskey
  • Patent number: 7497993
    Abstract: The present invention is a fluorescent temperature sensor or optical thermometer. The sensor includes a solution of 1,3-bis(1-pyrenyl)propane within a 1-butyl-1-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide ionic liquid solvent. The 1,3-bis(1-pyrenyl)propane remains unassociated when in the ground state while in solution. When subjected to UV light, an excited state is produced that exists in equilibrium with an excimer. The position of the equilibrium between the two excited states is temperature dependent.
    Type: Grant
    Filed: September 7, 2004
    Date of Patent: March 3, 2009
    Assignee: The United States of America as represented by the United States Department of Energy
    Inventors: Gary A. Baker, Sheila N. Baker, T. Mark McCleskey
  • Patent number: 7479843
    Abstract: Radiofrequency attenuator and method. The attenuator includes a pair of transparent windows. A chamber between the windows is filled with molten salt. Preferred molten salts include quarternary ammonium cations and fluorine-containing anions such as tetrafluoroborate (BF4?), hexafluorophosphate (PF6?), hexafluoroarsenate (AsF6?), trifluoromethylsulfonate (CF3SO3?), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N?), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N?) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C?). Radicals or radical cations may be added to or electrochemically generated in the molten salt to enhance the RF attenuation.
    Type: Grant
    Filed: November 16, 2004
    Date of Patent: January 20, 2009
    Assignee: Los Alamos National Security, LLC
    Inventors: Benjamin P. Warner, T. Mark McCleskey, Anthony K. Burrell, Anoop Agrawal, Simon B. Hall
  • Patent number: 7450292
    Abstract: Electrolyte solutions for electrochromic devices such as rear view mirrors and displays with low leakage currents are prepared using inexpensive, low conductivity conductors. Preferred electrolytes include bifunctional redox dyes and molten salt solvents with enhanced stability toward ultraviolet radiation. The solvents include lithium or quaternary ammonium cations, and perfluorinated sulfonylimide anions selected from trifluoromethylsulfonate (CF3SO3?), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N?), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N?) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C?). Electroluminescent, electrochromic and photoelectrochromic devices with nanostructured electrodes include ionic liquids with bifunctional redox dyes. Some of the electrolyte solutions color to red when devices employing the solutions are powered, leading to red or neutral electrooptic devices.
    Type: Grant
    Filed: September 22, 2006
    Date of Patent: November 11, 2008
    Assignee: Los Alamos National Security, LLC
    Inventors: Anthony K. Burrell, Anoop Agrawal, John P. Cronin, Juan C. L. Tonazzi, Benjamin P. Warner, T. Mark McCleskey
  • Publication number: 20080266642
    Abstract: Electrolyte solutions for electrochromic devices such as rear view mirrors and displays with low leakage currents are prepared using inexpensive, low conductivity conductors. Preferred electrolytes include bifunctional redox dyes and molten salt solvents with enhanced stability toward ultraviolet radiation. The solvents include lithium or quaternary ammonium cations, and perfluorinated sulfonylimide anions selected from trifluoromethylsulfonate (CF3SO3?), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N?), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N?) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C?). Electroluminescent, electrochromic and photoelectrochromic devices with nanostructured electrodes include ionic liquids with bifunctional redox dyes. Some of the electrolyte solutions color to red when devices employing the solutions are powered, leading to red or neutral electrooptic devices.
    Type: Application
    Filed: September 22, 2006
    Publication date: October 30, 2008
    Inventors: Anthony K. Burrell, Anoop Agrawal, John P. Cronin, Juan C.L. Tonazzi, Benjamin P. Warner, T. Mark McCleskey
  • Publication number: 20080220441
    Abstract: X-ray fluorescence (XRF) spectrometry has been used for detecting binding events and measuring binding selectivities between chemicals and receptors. XRF may also be used for estimating the therapeutic index of a chemical, for estimating the binding selectivity of a chemical versus chemical analogs, for measuring post-translational modifications of proteins, and for drug manufacturing.
    Type: Application
    Filed: October 10, 2007
    Publication date: September 11, 2008
    Inventors: Eva R. Birnbaum, Andrew T. Koppisch, Sharon M. Baldwin, Benjamin P. Warner, T. Mark McCleskey, Jeffrey Joseph Stewart, Jennifer A. Berger, Michael N. Harris, Anthony K. Burrell
  • Publication number: 20080128624
    Abstract: A nanocomposite scintillator is prepared using fast, bright, rare-earth doped nanopowder phosphor and a binder that is transparent to the emission of the phosphor.
    Type: Application
    Filed: March 27, 2007
    Publication date: June 5, 2008
    Inventors: D. Wayne Cooke, Edward A. McKigney, Ross E. Muenchausen, Bryan L. Bennett, Kevin C. Ott, Rico E. Del Sesto, T. Mark McCleskey, Anthony K. Burrell
  • Patent number: 7361327
    Abstract: Novel zeolites are produced by combining a polar solute, a silicon or phosphorous source, and a structure directing agent. Surfactants and a hydrophobic solvent are added to the previously mixed three species and shaken to disperse the surfactants. The reverse microemulsion is stirred overnight, at about room temperature and then iced for five to ten minutes. A metal source is added vigorously shaken for about two minutes. The mixture is then aged for about two hours at about room temperature. A mineralizer is added and the resultant mixture aged for about two hours at about room temperature. The mixture is heated to about 180° C., for a suitable time period. The final novel product is then isolated.
    Type: Grant
    Filed: August 17, 2005
    Date of Patent: April 22, 2008
    Assignee: Los Alamos National Security, LLC
    Inventors: William Tumas, Kevin C. Ott, T. Mark McCleskey, Matthew Z. Yates, Eva R. Birnbaum
  • Patent number: 7317106
    Abstract: A single-compartment reversible mirror device having a solution of aprotic molten salt, at least one soluble metal-containing species comprising metal capable of being electrodeposited, and at least one anodic compound capable of being oxidized was prepared. The aprotic molten salt is liquid at room temperature and includes lithium and/or quaternary ammonium cations, and anions selected from trifluoromethylsulfonate (CF3SO3?), bis(trifluoromethylsulfonyl)imide ((CF3SO2)2N?), bis(perfluoroethylsulfonyl)imide ((CF3CF2SO2)2N?) and tris(trifluoromethylsulfonyl)methide ((CF3SO2)3C?). A method for preparing substantially pure molten salts is also described.
    Type: Grant
    Filed: April 22, 2004
    Date of Patent: January 8, 2008
    Assignee: Los Alamos National Security, LLC
    Inventors: Benjamin P. Warner, T. Mark McCleskey, Anthony K. Burrell, Simon B. Hall
  • Patent number: 7129093
    Abstract: A method of determining beryllium or a beryllium compound thereof in a sample, includes providing a sample suspected of comprising beryllium or a compound thereof, extracting beryllium or a compound thereof from the sample by dissolving in a solution, adding a fluorescent indicator to the solution to thereby bind any beryllium or a compound thereof to the fluorescent indicator, and determining the presence or amount of any beryllium or a compound thereof in the sample by measuring fluorescence.
    Type: Grant
    Filed: March 30, 2004
    Date of Patent: October 31, 2006
    Assignee: Los Alamos National Security, LLC
    Inventors: T. Mark McCleskey, Deborah S. Ehler, Kevin D. John, Anthony K. Burrell, Gavin E. Collis, Edel M. Minogue, Benjamin P. Warner