Patents by Inventor T. Mark Zabriskie

T. Mark Zabriskie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for enhanced production of enduracidin in a genetically engineered strain of streptomyces fungicidicus
    Patent number: 11858967
    Abstract: This disclosure describes compositions and methods for enhanced production of enduracidin in genetically engineered strains of Streptomyces fungicidicus. In particular, the present disclosure describes the genetic manipulation of regulatory genes orf24 and orf18 associated with the enduracidin (enramycin) biosynthesis gene cluster from Streptomyces fungicidicus to generate vector constructs and recombinant strains producing greater yields of enduracidin.
    Type: Grant
    Filed: August 4, 2022
    Date of Patent: January 2, 2024
    Assignee: OREGON STATE UNIVERSITY
    Inventors: T. Mark Zabriskie, Xihou Yin
  • COMPOSITIONS AND METHODS FOR ENHANCED PRODUCTION OF ENDURACIDIN IN A GENETICALLY ENGINEERED STRAIN OF STREPTOMYCES FUNGICIDICUS
    Publication number: 20230120672
    Abstract: This disclosure describes compositions and methods for enhanced production of enduracidin in genetically engineered strains of Streptomyces fungicidicus. In particular, the present disclosure describes the genetic manipulation of regulatory genes orf24 and orf18 associated with the enduracidin (enramycin) biosynthesis gene cluster from Streptomyces fungicidicus to generate vector constructs and recombinant strains producing greater yields of enduracidin.
    Type: Application
    Filed: August 4, 2022
    Publication date: April 20, 2023
    Inventors: T. Mark Zabriskie, Xihou Yin
  • Compositions and methods for enhanced production of enduracidin in a genetically engineered strain of streptomyces fungicidicus
    Patent number: 11447530
    Abstract: This disclosure describes compositions and methods for enhanced production of enduracidin in genetically engineered strains of Streptomyces fungicidicus. In particular, the present disclosure describes the genetic manipulation of regulatory genes orf24 and orf18 associated with the enduracidin (enramycin) biosynthesis gene cluster from Streptomyces fungicidicus to generate vector constructs and recombinant strains producing greater yields of enduracidin.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: September 20, 2022
    Assignee: OREGON STATE UNIVERSITY
    Inventors: T. Mark Zabriskie, Xihou Yin
  • COMPOSITIONS AND METHODS FOR ENHANCED PRODUCTION OF ENDURACIDIN IN A GENETICALLY ENGINEERED STRAIN OF STREPTOMYCES FUNGICIDICUS
    Publication number: 20190359659
    Abstract: This disclosure describes compositions and methods for enhanced production of enduracidin in genetically engineered strains of Streptomycesfungicidicus. In particular, the present disclosure describes the genetic manipulation of regulatory genes orf24 and orf18 associated with the enduracidin (enramycin) biosynthesis gene cluster from Streptomyces fungicidicus to generate vector constructs and recombinant strains producing greater yields of enduracidin.
    Type: Application
    Filed: December 1, 2017
    Publication date: November 28, 2019
    Applicant: Oregon State University
    Inventors: T. Mark Zabriskie, Xihou Yin
  • Enduracidin biosynthetic gene cluster from
    Patent number: 8188245
    Abstract: This disclosure describes the molecular cloning of an enduracidin biosynthetic gene cluster from Streptomyces fungicidicus, and characterization of individual genes in the gene cluster and the proteins encoded thereby. An enduracidin gene cluster is located within a 116 kilobases genetic locus and includes 25 open reading frames (ORFs). An additional 23 ORFs flank the disclosed enduracidin biosynthetic gene cluster. Enduracidin analogs and a method for producing them by manipulation of the enduracidin gene cluster and specific genes therein are also disclosed.
    Type: Grant
    Filed: October 1, 2007
    Date of Patent: May 29, 2012
    Assignee: State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon State University
    Inventors: Xihou Yin, T. Mark Zabriskie
  • ENDURACIDIN BIOSYNTHETIC GENE CLUSTER FROM STREPTOMYCES FUNGICIDICUS
    Publication number: 20100035256
    Abstract: This disclosure describes the molecular cloning of an enduracidin biosynthetic gene cluster from Streptomyces fungicidicus, and characterization of individual genes in the gene cluster and the proteins encoded thereby. An enduracidin gene cluster is located within a 116 kilobases genetic locus and includes 25 open reading frames (ORFs). An additional 23 ORFs flank the disclosed enduracidin biosynthetic gene cluster Enduracidin analogs and a method for producing them by manipulation of the enduracidin gene cluster and specific genes therein are also disclosed.
    Type: Application
    Filed: October 1, 2007
    Publication date: February 11, 2010
    Inventors: Xihou Yin, T. Mark Zabriskie