Patents by Inventor T. Paul Wallace

T. Paul Wallace has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolated nucleic acid molecules which encode human anti-Lewis b antibodies
    Patent number: 6025481
    Abstract: The invention provides for the production of several humanized murine antibodies specific for the Lewis b antigen, which is recognized by the murine antibody 58-1066. The antigen is expressed on cell lines from colon, lung, bladder, breast, renal, pancreatic and ovarian cancers. The expression of the antigen is greatly increased in cancer tissues as compared to its expression in the corresponding normal tissue. The invention also provides for numerous polynucleotide encoding humanized Lewis b antigen specific antibodies, expression vectors for producing humanized Lewis b antigen specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis b antigen specific antibodies. Additionally, the invention provides methods of treating cancer using Lewis b antigen specific antibodies.
    Type: Grant
    Filed: May 18, 1998
    Date of Patent: February 15, 2000
    Assignee: Memorial Sloan-Kettering Cancer Center
    Inventors: T. Paul Wallace, William J. Harris, Frank J. Carr, Lloyd J. Old, Sydney Welt, Kunio Kitamura
  • Recombinant human anti-Lewis b antibodies
    Patent number: 5795961
    Abstract: The invention provides for the production of several humanized murine antibodies specific for the Lewis b antigen, which is recognized by the murine antibody 58-1066. The antigen is expressed on cell lines from colon, lung, bladder, breast, renal, pancreatic and ovarian cancers. The expression of the antigen is greatly increased in cancer tissues as compared to its expression in the corresponding normal tissue. The invention also provides for numerous polynucleotide encoding humanized Lewis b antigen specific antibodies, expression vectors for producing humanized Lewis b antigen specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis b antigen specific antibodies. Additionally, the invention provides methods of treating cancer using Lewis b antigen specific antibodies.
    Type: Grant
    Filed: February 14, 1995
    Date of Patent: August 18, 1998
    Assignee: Ludwig Institute for Cancer Research
    Inventors: T. Paul Wallace, William J. Harris, Frank J. Carr, Lloyd J. Old, Sydney Welt, Kunio Kitamura