Abstract: A system for decontamination of patient care equipment and a system for decontamination of an interior space. In some embodiments, a decontaminant distributor is provided in an enclosure and coupled to a decontaminant generator system. The decontaminant generator system may include a decontaminant generator removably coupled to the decontaminant distributor at an exterior of the enclosure for allowing the decontaminant generator to be removed and connected to another decontaminant distributor associated with another system for decontamination of patient care equipment. An air agitation system may be provided in the enclosure for agitating air and decontaminant in the enclosure. In some embodiments, a portable system may be transported to an interior space for decontaminating the items in the space using hot-air decontamination.