Abstract: A multiwell plate scanner comprises a detector for measuring an attribute of a sample which is scanned continuously over wells of a multiwell plate. A signal obtained during the scan may be sampled and digitized based on detector position over the multiwell plate. The scanner is also disclosed for scanning microarrays, bio-chips and areas of samples not having physical separations. The scanner may be used in a high throughput screening system comprising a storage and retrieval module, a sample distribution module, a reagent distribution module, and a detector which incorporates the scanner. The screening system may further comprise a transport module and a data processing and integration module for transporting samples between the components of the system and for controlling system operation.

Abstract: A method and apparatus is disclosed for automated on-the-fly dispensing of reagents. The apparatus includes a detachable reagent dispensing module supported by a support frame. The dispensing module includes a self-contained pressurized fluid delivery subsystem that facilitates efficient attachment and detachment of the module, including pressurized reagent containers and associated accessories arranged such that each reagent container has a discrete fluid path terminating at a corresponding discrete reagent dispensing tip. The dispensing tips are supported in a common dispensing head, and are arranged geometrically such that the centers of the dispensing tips are separated by distances corresponding to relevant dimensions of particular assay plates to be used therewith. Such a geometric arrangement allows for dispensing of multiple reagents substantially simultaneously into multiple corresponding target wells of the assay plate, efficiently and precisely.