Patents by Inventor T. William Hutchens

T. William Hutchens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6844165
    Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: January 18, 2005
    Assignee: Ciphergen Biosystems, Inc.
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Publication number: 20040266020
    Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
    Type: Application
    Filed: July 7, 2004
    Publication date: December 30, 2004
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Publication number: 20040266019
    Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
    Type: Application
    Filed: October 31, 2003
    Publication date: December 30, 2004
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Publication number: 20040245450
    Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
    Type: Application
    Filed: July 7, 2004
    Publication date: December 9, 2004
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Publication number: 20040238738
    Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
    Type: Application
    Filed: June 30, 2004
    Publication date: December 2, 2004
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Patent number: 6818411
    Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: November 16, 2004
    Assignee: Ciphergen Biosystems, Inc.
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Patent number: 6811969
    Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: November 2, 2004
    Assignee: Ciphergen Biosystems, Inc.
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Publication number: 20040191922
    Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
    Type: Application
    Filed: December 5, 2003
    Publication date: September 30, 2004
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Publication number: 20040142493
    Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
    Type: Application
    Filed: July 23, 2003
    Publication date: July 22, 2004
    Applicant: Ciphergen Biosystems, Inc.
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Publication number: 20040137427
    Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
    Type: Application
    Filed: July 23, 2003
    Publication date: July 15, 2004
    Applicant: Ciphergen Biosystems, Inc.
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Patent number: 6734022
    Abstract: This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: May 11, 2004
    Assignee: Baylor College of Medicine
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Patent number: 6579719
    Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: June 17, 2003
    Assignee: Ciphergen Biosystems, Inc.
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Publication number: 20030096224
    Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
    Type: Application
    Filed: April 30, 2002
    Publication date: May 22, 2003
    Applicant: CIPHERGEN BIOSYSTEMS, INC.
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Publication number: 20030054367
    Abstract: The present invention relates to methods for correlating gene and protein expression in a cell.
    Type: Application
    Filed: February 15, 2002
    Publication date: March 20, 2003
    Applicant: Ciphergen Biosystems, Inc.
    Inventors: William E. Rich, T. William Hutchens
  • Patent number: 6528320
    Abstract: The present invention comprises a sample presentation apparatus for mass spectrometry. More particulary, a complex is immoblized on the sample presenting surface.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: March 4, 2003
    Assignee: Baylor College of Medicine
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Publication number: 20020177242
    Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
    Type: Application
    Filed: August 5, 2002
    Publication date: November 28, 2002
    Applicant: CIPHERGEN BIOSYSTEMS, INC.
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Publication number: 20020155620
    Abstract: The present invention comprises a sample presentation apparatus for mass spectrometry. More particulary, a complex is immoblized on the sample presenting surface.
    Type: Application
    Filed: December 20, 2000
    Publication date: October 24, 2002
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Publication number: 20020155509
    Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
    Type: Application
    Filed: May 17, 2002
    Publication date: October 24, 2002
    Applicant: CIPHERGEN BIOSYSTEMS, INC.
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Publication number: 20020142343
    Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
    Type: Application
    Filed: May 17, 2002
    Publication date: October 3, 2002
    Applicant: CIPHERGEN BIOSYSTEMS, INC.
    Inventors: T. William Hutchens, Tai-Tung Yip
  • Publication number: 20020123043
    Abstract: This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity conditions, and detecting the analytes retained on the substrate by desorption spectrometry. The methods are useful in biology and medicine, including clinical diagnostics and drug discovery.
    Type: Application
    Filed: June 19, 1998
    Publication date: September 5, 2002
    Inventors: T. WILLIAM HUTCHENS, TAI-TUNG YIP