Patents by Inventor Ta-Chien Tseng

Ta-Chien Tseng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Short interfering RNA for treating cancer
    Patent number: 10174322
    Abstract: Disclosed herein is novel double-stranded short interfering ribonucleic acid (siRNA) capable of suppressing the translation of Aurora-A mRNA. Also disclosed are use of the novel siRNA as disclosed herein for manufacturing a medicament suitable for treating a cancer, which is mediated through epidermal growth factor receptor (EGFR) signaling. Accordingly, a pharmaceutical composition comprising the disclosed novel siRNA molecules is provided; as well as a method of treating a subject suffering from EGFR-mediated cancer via administering to the subject the disclosed novel siRNA molecule.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: January 8, 2019
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Liang-Yi Hung, Chien-Hsien Lai, Ta-Chien Tseng, Jeng-Chang Lee, Bo-Wen Lin
  • SHORT INTERFERING RNA FOR TREATING CANCER
    Publication number: 20180037888
    Abstract: Disclosed herein is novel double-stranded short interfering ribonucleic acid (siRNA) capable of suppressing the translation of Aurora-A mRNA. Also disclosed are use of the novel siRNA as disclosed herein for manufacturing a medicament suitable for treating a cancer, which is mediated through epidermal growth factor receptor (EGFR) signaling. Accordingly, a pharmaceutical composition comprising the disclosed novel siRNA molecules is provided; as well as a method of treating a subject suffering from EGFR-mediated cancer via administering to the subject the disclosed novel siRNA molecule.
    Type: Application
    Filed: February 23, 2016
    Publication date: February 8, 2018
    Applicant: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Liang-Yi HUNG, Chien-Hsien LAI, Ta-Chien TSENG, Jeng-Chang LEE, Bo-Wen LIN
  • Methods and compositions for analyzing nucleotide sequence mismatches using RNase H
    Patent number: 6596489
    Abstract: This invention relates generally to nucleic acid hybridization analysis. More specifically, a method for detecting a point mutation in a DNA strand is provided, which method uses, inter alia, a test nucleic acid strand complementary to a target DNA strand, said nucleic acid strand comprises a sufficient number of ribonucleotide residues that span the position of said point mutation to be detected to form a target DNA strand/test nucleic acid strand duplex and RNase H cleavage of said target DNA strand/test nucleic acid strand duplex. Kits and arrays for detecting a point mutation in a DNA strand comprising test nucleic acid strand comprising a sufficient number of ribonucleotide residues that span the position of said point mutation to be detected are also provided.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: July 22, 2003
    Assignee: Applied Gene Technologies
    Inventors: Nanibhushan Dattagupta, Ta-Chien Tseng
  • Methods and compositions for analyzing nucleotide sequence mismatches using RNase H
    Publication number: 20020142308
    Abstract: This invention relates generally to nucleic acid hybridization analysis. More specifically, a method for detecting a point mutation in a DNA strand is provided, which method uses, inter alia, a test nucleic acid strand complementary to a target DNA strand, said nucleic acid strand comprises a sufficient number of ribonucleotide residues that span the position of said point mutation to be detected to form a target DNA strand/test nucleic acid strand duplex and RNase H cleavage of said target DNA strand/test nucleic acid strand duplex. Kits and arrays for detecting a point mutation in a DNA strand comprising test nucleic acid strand comprising a sufficient number of ribonucleotide residues that span the position of said point mutation to be detected are also provided.
    Type: Application
    Filed: March 30, 2001
    Publication date: October 3, 2002
    Inventors: Nanibhushan Dattagupta, Ta-Chien Tseng