Abstract: Provided is a method of preparing a biodegradable film, which comprises the steps of coating a soluble supporting solution on a substrate, coating a prepolymer solution, pre-drying, crosslinking, and separating. With the technical means, the method can separate the biodegradable film from the substrate smoothly, thereby ensuring the film integrity of the produced biodegradable film.

Abstract: Provided are an anti-wrinkle composition, an anti-wrinkle microneedle patch and a preparation method thereof. The anti-wrinkle microneedle patch comprises a base and multiple needles, the base has an upper surface, and the needles are formed on the upper surface; wherein, a material of each needle comprises a low-molecular hyaluronic acid, a modified hyaluronic acid and a cross-linked hyaluronic acid. A weight ratio of the modified hyaluronic acid to the low-molecular hyaluronic acid is 0.1 to 4, and a weight ratio of the modified hyaluronic acid to the cross-linked hyaluronic acid is less than 30. Accordingly, the anti-wrinkle microneedle patch has effects of moisturizing the skin, elevating the thickness and the strength of the skin, and smoothing and reducing the wrinkles.

Abstract: Provided is a microneedle patch comprising a substrate part and multiple needle parts protruding from the substrate part. The substrate part consists of a diffusion-proof layer and a base, and each needle part consists of a needle tip, a diffusion-proof layer and a base. The diffusion-proof layer of each needle part is formed between the needle tip and the base of the corresponding needle part. The diffusion-proof layer of the substrate part and the diffusion-proof layer of needle part are one-piece structures, and so are the base of the substrate part and the base of the needle part. The diffusion-proof layer of the microneedle patch can prevent the active ingredients from diffusing to the base, limit the active ingredients to the needle tip and control the carrying quantity thereof.

Abstract: Provided is a method of preparing a biodegradable film, which comprises the steps of coating a soluble supporting solution on a substrate, coating a prepolymer solution, pre-drying, crosslinking, and separating. With the technical means, the method can separate the biodegradable film from the substrate smoothly, thereby ensuring the film integrity of the produced biodegradable film.

Abstract: Provided is a method of preparing a biodegradable film, which comprises the steps of coating a soluble supporting solution on a substrate, coating a prepolymer solution, pre-drying, crosslinking, and separating. With the technical means, the method can separate the biodegradable film from the substrate smoothly, thereby ensuring the film integrity of the produced biodegradable film.

Abstract: The present invention relates to a base composition for a microneedle patch and a microneedle patch comprising the same. The base composition comprises a first HPMC, a second HPMC and PVP/VA, wherein the viscosity of the first HPMC is greater than that of the second HPMC, the weight ratio of the first HPMC relative to the second HPMC is 1:0.1 to 1:1.2, and the amount of the PVP/VA is 0.25 wt % to 2 wt %. By controlling the constitution of the base composition, the microneedle patch can not only be demolded smoothly during the stage of the production, but also obtain the desired softness, flatness, flexibility, skin adhesion during the stage of use and humidity resistance during the stage of storage.

Abstract: Provided is a method of preparing a biodegradable film, which comprises the steps of coating a soluble supporting solution on a substrate, coating a prepolymer solution, pre-drying, crosslinking, and separating. With the technical means, the method can separate the biodegradable film from the substrate smoothly, thereby ensuring the film integrity of the produced biodegradable film.

Abstract: A barrier structure is disclosed. The barrier structure is utilized for covering at least a part of an object for protecting the object from gas and water in an external environment and includes a solid layer and a liquid layer. The solid layer has a first surface and a second surface. The first surface directly contacts the external environment. The solid layer is penetrable by at least one type of gas. The liquid layer contacts the second surface. An interface is formed between the second surface of the solid layer and the liquid layer. The barrier structure has ductility, flexibility, and bendability to cover the object, protect the object from the external environment, and provide the required barrier characteristic against the water or the gas.

Abstract: A gas barrier film and method for manufacturing the abovementioned gas barrier film are disclosed in the present invention. The gas barrier film is applied in electronic product, food, medicine and other fields for protecting them from gas and water. The gas barrier film comprises a gas barrier layer and pluralities of cladding layers. The gas barrier layer is a liquid layer, and the cladding layers are disposed on the opposite surface of the gas barrier layer.

Abstract: The present invention discloses an apparatus for block type extrusion coating, and a process for forming block coating or grid-type coating on a substrate. The present invention uses a die set composed of an upper mold, a lower mold and a shim therebetween, which can be used to form a plurality of coated stripes. The present invention further uses several control valves, pumps and a controller to intermittently extrude a coating solution from the die set, so that the stripe coating is converted to a block coating. The block coated substrate can be rotated 90 degrees, followed by a stripe coating process to form a grid-type coating on the substrate.

Abstract: The present invention discloses an apparatus for block type extrusion coating, and a process for forming block coating or grid-type coating on a substrate. The present invention uses a die set composed of an upper mold, a lower mold and a shim therebetween, which can be used to form a plurality of coated stripes. The present invention further uses several control valves, pumps and a controller to intermittently extrude a coating solution from the die set, so that the stripe coating is converted to a block coating. The block coated substrate can be rotated 90 degrees, followed by a stripe coating process to form a grid-type coating on the substrate.

Abstract: The present invention discloses an apparatus for block type extrusion coating, and a process for forming block coating or grid-type coating on a substrate. The present invention uses a die set composed of an upper mold, a lower mold and a shim therebetween, which can be used to form a plurality of coated stripes. The present invention further uses several control valves, pumps and a controller to intermittently extrude a coating solution from the die set, so that the stripe coating is converted to a block coating. The block coated substrate can be rotated 90 degrees, followed by a stripe coating process to form a grid-type coating on the substrate.

Abstract: The invention is related to the formation of three different and repeated stripes abbreviate as ABCABC-typed or A_B_C-typed at the die exit. The symbol, “_”, implies that there is no coating between two adjacent stripes. In this invention a guide shim and a guide die are inserted between two coating dies. Three different coating solutions will flow into the die assembly through different inlet positions. Two of which are introduced from the two coating dies will flow through the multiple channels provided in the guide shim and the guide die respectively and then contact with each other and with the third solution introduced from a side of the guide die in the same slot section to form the ABCABC-typed stripes. The coating solutions can also flow through the multiple channels to the same slot section but not contact each other to form the A_B_C-typed stripes at the die exit with a modification of the die assembly.

Abstract: This invention is related to a die set and method for the production of multiple stripes with two different materials A and B adjacent to each other. The special feature of this invention is that a specially designed shim is inserted between two pieces of coating dies. When liquids A and B enter the two sides of the die set separately, B liquid will flow through the distribution passages in the shim to form multiple stripes and then contact stripes of A liquid in the same slot section. The multiple stripes of repeated coating liquids that consists of ABAB patterns will be generated once the multiple stripes are coated and dried on the substrate.