Patents by Inventor Ta-Jyh Lee

Ta-Jyh Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of farnesyl-protein transferase
    Patent number: 5686472
    Abstract: The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: November 11, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Neville J. Anthony, S. Jane deSolms, Ta Jyh Lee, deceased
  • Farnesyl pyrophosphate analogs
    Patent number: 5362906
    Abstract: The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention, and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: June 18, 1993
    Date of Patent: November 8, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Neville J. Anthony, Ta-Jyh Lee, Robert L. Smith, Gerald E. Stokker
  • Farnesyl pyrophosphate analogs
    Patent number: 5298655
    Abstract: The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention, and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.
    Type: Grant
    Filed: September 27, 1991
    Date of Patent: March 29, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Neville J. Anthony, Ta-Jyh Lee, Robert L. Smith, Gerald E. Stokker
  • Antihypercholesterolemic compounds
    Patent number: 4937259
    Abstract: Compounds of Formula (I) and (II): ##STR1## are HMG-CoA reductase inhibitors.
    Type: Grant
    Filed: June 9, 1989
    Date of Patent: June 26, 1990
    Assignee: Merck & Co., Inc.
    Inventor: Ta Jyh Lee
  • Antihypercholesterolemic compounds
    Patent number: 4916162
    Abstract: Novel 3-hydroxy-3-methylglutary-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1## and pharmaceutically acceptable salts of the compounds (II) in which Z is hydrogen are disclosed.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: April 10, 1990
    Assignee: Merck & Co., Inc.
    Inventors: William F. Hoffman, Clarence S. Rooney, Ta Jyh Lee
  • Intermediates and processes for .beta.-6-hydroxymethyl HMG-CoA reductable inhibitors
    Patent number: 4894466
    Abstract: This invention discloses intermediates and a process for the preparation of 6-desmethyl-6-.beta.-hydroxymethyl derivatives of lovastatin and analogs thereof at the 8-acyl side chain.
    Type: Grant
    Filed: February 29, 1988
    Date of Patent: January 16, 1990
    Assignee: Merck & Co., Inc.
    Inventors: Ta Jyh Lee, William F. Hoffman
  • Intermediates for 6-alpha-hydroxymethyl HMG-CoA reductase inhibitors
    Patent number: 4855456
    Abstract: This invention discloses intermediates and a process for the preparation of 6-desmethyl-6-.alpha.-hydroxymethyl derivatives of lovastatin and analogs thereof at the 8-acyl side chain.
    Type: Grant
    Filed: February 29, 1988
    Date of Patent: August 8, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Ta Jyh Lee, William F. Hoffman
  • Intermediates useful in the preparation of HMG-COA reductase inhibitors
    Patent number: 4833258
    Abstract: Novel intermediates and a novel process for their preparation, where said intermediates are useful in the preparation of 6-hydroxymethyl and related oxidation derivatives of mevinolin and analogs thereof, are disclosed.
    Type: Grant
    Filed: February 17, 1987
    Date of Patent: May 23, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Ta Jyh Lee
  • Antihypercholesterolemic compounds
    Patent number: 4503072
    Abstract: Compounds of general structural formula: ##STR1## wherein Q is: ##STR2## or pharmaceutically acceptable salts, C.sub.1-3 alkyl esters or .alpha.-monoglyceride when Q is a dihydroxy acid are useful as antihypercholesterolemic agents for the treatment of atherosclerosis, familial hypercholesterolemia, hyperlipemia and like diseases. They also have useful antifungal activity.
    Type: Grant
    Filed: June 18, 1984
    Date of Patent: March 5, 1985
    Assignee: Merck & Co., Inc.
    Inventors: William F. Hoffman, Ta-Jyh Lee, Robert L. Smith, Alvin K. Willard
  • Antihypercholesterolemic compounds
    Patent number: 4472426
    Abstract: Compounds of general structural formula: ##STR1## wherein Q is: ##STR2## or pharmaceutically acceptable salts, C.sub.1-3 alkyl esters or .alpha.-monoglyceride when Q is a dihydroxy acid are useful as antihypercholesterolemic agents for the treatment of atherosclerosis, familial hypercholesterolemia, hyperlipemia and like diseases. They also have useful antifungal activity.
    Type: Grant
    Filed: December 22, 1982
    Date of Patent: September 18, 1984
    Assignee: Merck & Co., Inc.
    Inventors: William F. Hoffman, Ta-Jyh Lee, Robert L. Smith, Alvin K. Willard
  • Antihypercholesterolemic compounds
    Patent number: 4282155
    Abstract: 6(R)-[2-(8'-Etherified-hydroxy-2',6'-dimethylpolyhydronaphthyl-1')-ethyl]-4 (R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones are prepared from the corresponding 8'-acyloxy compounds, some of which are naturally occurring, by protection of the 4(R)-hydroxyl and the 2-keto group, followed by reductive removal of the 8'-acyloxy group, etherification of the resulting 8'-hydroxyl and removal of the protecting groups. The products inhibit the biosynthesis of cholesterol.
    Type: Grant
    Filed: August 5, 1980
    Date of Patent: August 4, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Ta-jyh Lee
  • Interphenylene 9-thia-11-oxo-12-azaprostanoic acid compounds
    Patent number: 4260771
    Abstract: This invention relates to novel interphenylene 9-thia-11-oxo-12-azaprostanoic acid compounds, salts, and derivatives thereof. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, as platelet aggregation inhibitors, and for the treatment of certain autoimmune diseases.
    Type: Grant
    Filed: December 20, 1979
    Date of Patent: April 7, 1981
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Ta-Jyh Lee, John B. Bicking
  • Interphenylene 9-thia-11-oxo-12-aza-prostanoic acids
    Patent number: 4225609
    Abstract: This invention relates to novel interphenylene 9-thia-11-oxo-12-azaprostanoic acid compounds, salts, and derivatives thereof. These compounds are exceptionally potent renal vasodilators and antihypertensives which are active when administered orally but which have a more specific type of biological activity than that of many of the natural prostaglandins and their synthetic analogs or derivatives.
    Type: Grant
    Filed: August 30, 1978
    Date of Patent: September 30, 1980
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Ta-jyh Lee, John B. Bicking
  • 3-Thiazolidinyl heptanoic acids
    Patent number: 4102888
    Abstract: This invention relates to novel 8-aza-9-oxo-11-thia-, -11-oxothia-, and -11-dioxothia-prostanoic acid compounds, salts, and derivatives thereof and also to processes for the preparation of such compounds. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of certain autoimmune diseases, and in preventing thrombus formation.
    Type: Grant
    Filed: April 20, 1977
    Date of Patent: July 25, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Ta-Jyh Lee, Edward J. Cragoe, Jr.
  • Crystalline dipilocarpinium pamoate
    Patent number: 4076942
    Abstract: This invention relates to novel crystalline dipilocarpinium pamoate useful as an agent, for lowering elevated intraocular pressure in glaucomatous patients, as well as to a process for preparing said compound and novel intermediates thereof.
    Type: Grant
    Filed: October 1, 1975
    Date of Patent: February 28, 1978
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Ta-Jyh Lee
  • Certain thiazolidine compounds
    Patent number: 4059587
    Abstract: This invention relates to novel 8-aza-9-oxo-11-thia-, -11-oxothia-, and -11-dioxothia-prostanoic acid compounds, salts, and derivatives thereof and also to processes for the preparation of such compounds. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, for the treatment of certain autoimmune diseases, and in preventing thrombus formation.
    Type: Grant
    Filed: May 24, 1976
    Date of Patent: November 22, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Ta-Jyh Lee, Edward J. Cragoe, Jr.
  • Pilocarpine salts
    Patent number: 4045558
    Abstract: Pilocarpinium 2-naphthalenesulfonate, pilocarpinium 2,5-dihydroxybenzoate, pilocarpinium dihydrogenphosphate, pilocarpinium 2-chloro-4,6-disulfamoylphenoxide, and pilocarpinium 3,5-di-tert-butylsalicylate, novel compounds effective in the treatment of glaucoma.
    Type: Grant
    Filed: October 8, 1975
    Date of Patent: August 30, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Ta-Jyh Lee
  • Novel analogs of prostaglandins with 4-oxo-thiazolidinyl nucleus and method of preparation thereof
    Patent number: 4022794
    Abstract: This invention relates to novel 9-thia-, 9-oxothia-, and 9-dioxothia-11-oxo-12-azaprostanoic acid compounds, salts, and derivatives thereof and also to processes for the preparation of such compounds. These compounds have prostaglandin-like biological activity and are particularly useful as renal vasodilators, as platelet aggregation inhibitors, and for the treatment of certain autoimmune diseases.
    Type: Grant
    Filed: May 24, 1976
    Date of Patent: May 10, 1977
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Ta-Jyh Lee, Edward J. Cragoe, Jr.
  • HMG-CoA reductase inhibitors
    Patent number: RE36520
    Abstract: Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formula (II): ##STR1##
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: January 18, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Wasyl Halczenko, George D. Hartman, Gerald E. Stokker, Edward S. Inamine, Otto D. Hensens, David R. Houck, Ta Jyh Lee