Abstract: A method includes bonding a bottom die to a carrier, and bonding a top die to the bottom die. The top die includes a semiconductor substrate, and the semiconductor substrate has a first thermal conductivity. The method further includes encapsulating the top die in a gap-fill region, bonding a supporting substrate to the top die and the gap-fill region to form a reconstructed wafer, wherein the supporting substrate has a second thermal conductivity higher than the first thermal conductivity, de-bonding the reconstructed wafer from the carrier, and forming electrical connectors on the bottom die.

Abstract: The present invention relates to a bioreactor for generating uniform distribution of shear stress, comprising: a cone, having a cone surface with an outline of modified catenary; a container, having a fixed plate at the bottom inside the accommodating space of said container, and said fixed plate comprises a plurality of reservoirs; wherein the cone tip located above the center of said fixed plate is capable of loading culture media into the accommodating space of said container, that is, into the space between the cone surface and the fixed plate. More uniform shear stress can be generated in the culture media to act on the sample in the reservoirs of the fixed plate when the cone rotates and makes the culture media run. The bioreactor of the present invention can be applied to generate uniform shear stress acting on the fixed plate despite the distance between the cone tip and the fixed plate.

Abstract: The present invention relates to a bioreactor for generating uniform distribution of shear stress, comprising: a cone, having a cone surface with an outline of modified catenary; a container, having a fixed plate at the bottom inside the accommodating space of said container, and said fixed plate comprises a plurality of reservoirs; wherein the cone tip located above the center of said fixed plate is capable of loading culture media into the accommodating space of said container, that is, into the space between the cone surface and the fixed plate. More uniform shear stress can be generated in the culture media to act on the sample in the reservoirs of the fixed plate when the cone rotates and makes the culture media run. The bioreactor of the present invention can be applied to generate uniform shear stress acting on the fixed plate despite the distance between the cone tip and the fixed plate.