Patents by Inventor Ta-Yuan Chang

Ta-Yuan Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for detecting intracellular cholesterol
    Patent number: 7361482
    Abstract: The present invention relates to a method of detecting intracellular cholesterol. The method provides contacting a permeabilized cell with labeled c? complex. Methods of using this detection method to identify agents which modulate cholesterol accumulation in a cell are also provided.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: April 22, 2008
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Shigeki Sugii
  • Method for detecting intracellular cholesterol
    Patent number: 7186519
    Abstract: The present invention relates to a method of detecting intracellular cholesterol. The method provides contacting a permeabilized cell with labeled C? complex. Methods of using this detection method to identify agents which modulate cholesterol accumulation in a cell are also provided.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: March 6, 2007
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Shigeki Sugii
  • High-throughput screening assay for cholesterol inhibitors and inhibitors identified thereby
    Patent number: 7049086
    Abstract: The present invention provides a high-throughput screening assay to identify test agents as cholesterol inhibitors via mutant NCP1 mammalian cells. Also provided are cholesterol inhibiting agents identified in accordance with this assay and methods for using such agents to inhibit cholesterol accumulation in cells.
    Type: Grant
    Filed: February 25, 2002
    Date of Patent: May 23, 2006
    Assignee: Trustees of Dartmouth College
    Inventor: Ta-Yuan Chang
  • Method for detecting intracellular cholesterol
    Publication number: 20060094772
    Abstract: The present invention relates to a method of detecting intracellular cholesterol. The method provides contacting a permeabilized cell with labeled c? complex. Methods of using this detection method to identify agents which modulate cholesterol accumulation in a cell are also provided.
    Type: Application
    Filed: October 31, 2003
    Publication date: May 4, 2006
    Inventors: Ta-Yuan Chang, Shigeki Sugii
  • High-throughput screening assay for cholesterol inhibitors and inhibitors identified thereby
    Publication number: 20040115613
    Abstract: The present invention provides a high-throughput screening assay to identify test agents as cholesterol inhibitors via mutant NCP1 mammalian cells. Also provided are cholesterol inhibiting agents identified in accordance with this assay and methods for using such agents to inhibit cholesterol accumulation in cells.
    Type: Application
    Filed: August 26, 2003
    Publication date: June 17, 2004
    Inventor: Ta-Yuan Chang
  • Method for detecting intracellular cholesterol
    Publication number: 20040091944
    Abstract: The present invention relates to a method of detecting intracellular cholesterol. The method provides contacting a permeabilized cell with labeled C&thgr; complex. Methods of using this detection method to identify agents which modulate cholesterol accumulation in a cell are also provided.
    Type: Application
    Filed: November 13, 2002
    Publication date: May 13, 2004
    Inventors: Ta-Yuan Chang, Shigeki Sugii
  • Screening method for SREBP pathway-specific inhibitors
    Patent number: 6602710
    Abstract: This invention provides a screening method for sterol regulatory element binding protein (SREBP) pathway-specific inhibitors using a mutant cultured cell, as well as therapeutic agents for hyperlipemia, arterial sclerosis, obesity or cancer containing an SREBP pathway-specific inhibitor selected by said screening method.
    Type: Grant
    Filed: August 27, 1998
    Date of Patent: August 5, 2003
    Assignees: Chugai Seiyaku Kabushiki Kaisha, Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Tatsuhiko Kodama, Takao Hamakubo, Yoshiki Kawabe
  • Acyl coenzyme A : cholesterol acyltransferase (ACAT)
    Patent number: 5968749
    Abstract: This invention pertains to purified, biologically active acyl coenzyme A: cholesterol acyltransferase (ACAT) and to nucleic acid (DNA or RNA) encoding acyl coenzyme A: cholesterol acyltransferase. The nucleic acid, or a fragment thereof, may be ligated with an expression vector and transfected into cells to express acyl coenzyme A: cholesterol acyltransferase activity in intact cells and in cell-free extracts.
    Type: Grant
    Filed: July 23, 1998
    Date of Patent: October 19, 1999
    Inventors: Ta-Yuan Chang, Catherine C.Y. Chang
  • Acyl coenzyme A:cholesterol acyltransferase (ACAT)
    Patent number: 5834283
    Abstract: This invention pertains to purified, biologically active acyl coenzyme A: cholesterol acyltransferase (ACAT) and to nucleic acid (DNA or RNA) encoding acyl coenzyme A:cholesterol acyltransferase. The nucleic acid, or a fragment thereof, may be ligated with an expression vector and transfected into cells to express acyl coenzyme A:cholesterol acyltransferase activity in intact cells and in cell-free extracts.
    Type: Grant
    Filed: July 31, 1995
    Date of Patent: November 10, 1998
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang
  • Cloned gene encoding acylcoenzyme A: cholesterol acyltransferase (ACAT)
    Patent number: 5484727
    Abstract: This invention pertains to purified, biologically active acyl coenzyme A: cholesterol acyltransferase (ACAT) and to nucleic acid (DNA or RNA) encoding acyl coenzyme A: cholesterol acyltransferase. The nucleic acid, or a fragment thereof, may be ligated with an expression vector and transfected into cells to express acyl coenzyme A: cholesterol acyltransferase activity in intact cells and in cell-free extracts.
    Type: Grant
    Filed: September 10, 1993
    Date of Patent: January 16, 1996
    Assignee: Trustees of Dartmouth College
    Inventors: Ta-Yuan Chang, Catherine C. Y. Chang