Patents by Inventor Tacey L. Prewett

Tacey L. Prewett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Three dimensional optic tissue culture and process
    Patent number: 5962324
    Abstract: A process for artificially producing three-dimensional optic tissue has been developed. The optic cells are cultured in a bioreactor at low shear conditions. The tissue forms as normal, functional tissue grows with tissue organization and extracellular matrix formation.
    Type: Grant
    Filed: May 13, 1994
    Date of Patent: October 5, 1999
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Adminstration
    Inventors: Kim C. O'Connor, Glenn F. Spaulding, Thomas J. Goodwin, Laurie A. Aten, Karen M. Francis, Delmar R. Caldwell, Tacey L. Prewett, Wendy S. Fitzgerald
  • Production of normal mammalian organ culture using a medium containing mem-alpha, leibovitz L-15, glucose galactose fructose
    Patent number: 5858783
    Abstract: Normal mammalian tissue and the culturing process has been developed for the three groups of organ, structural and blood tissue. The cells are grown in vitro under micro-gravity culture conditions and form three dimensional cells aggregates with normal cell function. The microgravity culture conditions may be microgravity or simulated micro-gravity created in a horizontal rotating wall culture vessel. The medium used for culturing the cells, especially a mixture of epithelial and mesenchymal cells contains a mixture of Mem-alpha and Leibovits L15 supplemented with glucose, galactose and fructose.
    Type: Grant
    Filed: March 1, 1996
    Date of Patent: January 12, 1999
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, David A. Wolf, Glenn F. Spaulding, Tacey L. Prewett
  • Cultured high-fidelity three-dimensional human urogenital tract carcinomas and process
    Patent number: 5851816
    Abstract: Artificial high-fidelity three-dimensional human urogenital tract carcinomas are propagated under in vitro-microgravity conditions from carcinoma cells. Artificial high-fidelity three-dimensional human urogenital tract carcinomas are also propagated from a coculture of normal urogenital tract cells inoculated with carcinoma cells. The microgravity culture conditions may be microgravity or simulated microgravity created in a horizontal rotating wall culture vessel.
    Type: Grant
    Filed: December 27, 1993
    Date of Patent: December 22, 1998
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, Tacey L. Prewett, Glenn F. Spaulding, David A. Wolf
  • Recombinant protein production and insect cell culture and process
    Patent number: 5637477
    Abstract: A process has been developed for recombinant production of selected polypeptides using transformed insect cells cultured in a horizontally rotating culture vessel modulated to create low shear conditions. A metabolically transformed insect cell line is produced using the culture procedure regardless of genetic transformation. The recombinant polypeptide can be produced by an alternative process using virully infected or stably transformed insect cells containing a gene encoding the described polypeptide. The insect cells can also be a host for viral production.
    Type: Grant
    Filed: August 16, 1994
    Date of Patent: June 10, 1997
    Assignee: The United States of America as respresented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Glenn F. Spaulding, Thomas J. Goodwin, Kim C. O'Connor, Karen M. Francis, Angela D. Andrews, Tacey L. Prewett
  • Method for producing non-neoplastic, three dimensional, mammalian tissue and cell aggregates under microgravity culture conditions and the products produced therefrom
    Patent number: 5496722
    Abstract: Normal mammalian tissue and the culturing process has been developed for the three groups of organ, structural and blood tissue. The cells are grown in vitro under microgravity culture conditions and form three dimensional cells aggregates with normal cell function. The microgravity culture conditions may be microgravity or simulated microgravity created in a horizontal rotating wall culture vessel.
    Type: Grant
    Filed: May 25, 1993
    Date of Patent: March 5, 1996
    Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space Administration
    Inventors: Thomas J. Goodwin, David A. Wolf, Glenn F. Spaulding, Tacey L. Prewett