Patents by Inventor Tad H. Koch

Tad H. Koch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10912767
    Abstract: The present invention includes compounds of the class anthracycline that have been modified to include photo-activated prodrug anthracycline compounds that are useful in the treatment of cancer. One example composition of the invention may include photodoxazolidine which may be synthesized in two steps from 4,5-dimethoxy-2-nitrobenzyl alcohol and doxazolidine. In this embodiment commercial 4,5-dimethoxyl-2-nitrobenzyl alcohol reacts with p-nitrophenylchloroformate to give the p-nitrophenyl carbonate of the benzyl alcohol derivative. The p-nitrophenyl carbonate is then reacted with doxazolidine to give the exemplary photodoxazolidine composition.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: February 9, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventors: Tad H. Koch, Benjamin L. Barthel, Hang Hubert Yin, Ryo Tamura, Alla Balabanova
  • Publication number: 20180110756
    Abstract: Therapeutically effective prodrug compounds for the prevention and treatment of cancer and pharmaceutical compositions containing these compounds as well as methods of making and using these compounds.
    Type: Application
    Filed: April 27, 2016
    Publication date: April 26, 2018
    Inventors: Tad H. KOCH, Benjamin L. BARTHEL, Hang Hubert YIN, Ryo TAMURA, Alla BALABANOVA
  • Patent number: 8404650
    Abstract: The invention provides therapeutically effective compounds for the prevention and treatment of cancer and pharmaceutical compositions containing these compounds as well as methods of using and administering these compounds. The invention also includes methods of activating a prodrug of these therapeutically effective compounds by the administration of a peptide-directed targeting construct that delivers a prodrug-activating enzyme to a target activation site.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: March 26, 2013
    Assignee: The Regents of the University of Colorado, a body corporate
    Inventors: Tad H. Koch, David J. Burkhart, Glen C. Post, Jordan W. Nafie, Brian T. Kalet, Benjamin L. Barthel, Daniel L. Rudnicki
  • Publication number: 20110135618
    Abstract: The invention provides therapeutically effective compounds for the prevention and treatment of cancer and pharmaceutical compositions containing these compounds as well as methods of using and administering these compounds. The invention also includes methods of activating a prodrug of these therapeutically effective compounds by the administration of a peptide-directed targeting construct that delivers a prodrug-activating enzyme to a target activation site.
    Type: Application
    Filed: October 30, 2006
    Publication date: June 9, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO
    Inventors: Tad H. Koch, David J. Burkhart, Glen C. Post, Jordan W. Nafie, Brian T. Kalet, Benjamin L. Barthel, Daniel L. Rudnicki
  • Patent number: 6677309
    Abstract: Monomeric and dimeric anti-cancer drug aldehyde conjugate compounds and pharmaceutically acceptable salts thereof. Specifically, monomeric and dimeric aldehyde conjugates of 1-2, dihetero-substituted anti-cancer drugs, including monomeric and dimeric aldehyde conjugates of anthracyclines, are provided. Also provided are pro-drugs which, after administration, release monomeric aldehyde conjugates. Further provided are pharmaceutical and therapeutic compositions containing anti-cancer drug aldehyde conjugates and methods of treating cancer using the aldehyde conjugates.
    Type: Grant
    Filed: February 27, 1998
    Date of Patent: January 13, 2004
    Assignee: University Technology Corporation
    Inventors: Dylan J. Taatjes, David J. Fenick, Tad H. Koch
  • Patent number: 5646177
    Abstract: Disclosed herein are new anthracyclines which are derived from conjugation with glutathione, for example from conjugation of adriamycin, daunomycin and menogaril with glutathione: compounds 7 I, 7 II, 8 I, 8 II, 9 I and 9II, are obtained by reduction of the anthracycline followed by reaction of the reduced product with glutathione in aqueous (H.sub.2 O or D.sub.2 O) or organic solvent. The invention also provides salts of these glutathione derivatives, particularly salts formed from anthracycline glutathione anions with anthracycline cations. These anthracycline derivatives are useful as antibiotics, as antitumor agents, and in the treatment of AIDS. These derivatives are particularly useful in the treatment of cancer when multiple drug resistance is present.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: July 8, 1997
    Assignees: Board of Regents of The University of Colorado, Consiglio Nazionale Delle Richerche
    Inventors: Tad H. Koch, Giorgio Gaudiano
  • Patent number: 5087388
    Abstract: A method for releasing trialkylamines into the dye circulation stream of a dye laser and a filter cartridge containing a resin bound anion stabilizing agent for insertion into the dye circulation stream of a dye laser improves the performance thereof, especially with respect to excimer and flashlamp pumped coumarin and carbostyryl dye lasers. The resin bears quaternary ammonium groups, and borohydride, bromide, hudroxide or chloride may be used as the counter ion. A resin bound borohydride stabilizing agent is capable of releasing trialkylamine into the dye circulation stream and reducing the carbonyl functional groups of polyarbonyl material in the stream to less light absorbing alcohol functional groups. A resin bound chloride stabilizing agent is capable of releasing trialkylamine into the dye circulation stream as a quencher and radical scavenger.
    Type: Grant
    Filed: February 26, 1990
    Date of Patent: February 11, 1992
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Robert P. Mahoney, Tad H. Koch
  • Patent number: 4632922
    Abstract: The present invention discloses a bi(3,5-dimethyl-5-hydroxymethyl-2-oxomorpholin-3-yl) compound and its efficacy as a rescue agent against anthracycline and mitomycin C induced tissue damage. A method of synthesizing said compound has also been described.
    Type: Grant
    Filed: October 24, 1985
    Date of Patent: December 30, 1986
    Assignees: The United States of America as represented by the Department of Health and Human Services, University of Colorado Foundation, Inc.
    Inventors: Steven D. Averbuch, Nicholas R. Bachur, Giorgio Gaudiano, Tad H. Koch
  • Patent number: 4505792
    Abstract: Subjecting 1,4-bis-[(pyrrolin-3-onyl)methylamino]-2-butyne to ultraviolet irradiation effects rearrangement in greater than 80% yield to 1,4-bis-[(isocyanatocyclopropyl)methylamino]-2-butyne. The diisocyanate is useful in the synthesis of polyurethanes and polyureas and also for the in situ photochemical generation of a cross-linking agent for polyurethanes and structurally related polymers.
    Type: Grant
    Filed: September 22, 1982
    Date of Patent: March 19, 1985
    Assignee: University Patents, Inc.
    Inventors: Tad H. Koch, Barry J. Swanson
  • Patent number: 4428859
    Abstract: 1,4-Diazabicyclo[2.2.2]octane (DABCO) has been shown to extend the lifetime of several organic laser dyes in nitrogen laser pumped and flashlamp pumped dye lasers. With 0.010M DABCO, average power output in coumarin dye lasers remains at better than 90% of initial power at least three times longer than without DABCO.
    Type: Grant
    Filed: November 12, 1982
    Date of Patent: January 31, 1984
    Assignee: University Patents, Inc.
    Inventors: Tad H. Koch, Robert J. von Trebra
  • Patent number: 4380647
    Abstract: Subjecting 1,4-bis-[(pyrrolin-3-onyl)methylamino]-2-butyne to ultraviolet irradiation effects rearrangement in greater than 80% yield to 1,4-bis-[(isocyanatocycloprolpyl)methylamino]-2-butyne. The diisocyanate is useful in the synthesis of polyurethanes and polyureas and also for the in situ photochemical generation of a cross-linking agent for polyurethanes and structurally related polymers.
    Type: Grant
    Filed: March 3, 1981
    Date of Patent: April 19, 1983
    Assignee: University Patents, Inc.
    Inventors: Tad H. Koch, Barry J. Swanson