Abstract: Provided is a method for producing particles including: preparing a dispersion liquid with Liquid A and Liquid B, where Liquid A is a solution containing a physiologically active substance, and Liquid B is a solution containing a base material and a surfactant; and forming particles from the dispersion liquid.

Abstract: A discharge device is provided. The discharge device includes a liquid feed-discharger, and the liquid feed-discharger includes a feed unit configured to feed a liquid and a discharge unit having discharge holes configured to discharge the liquid fed by the feed unit. A ratio (X/Y) of a maximum cross-sectional area X (mm2) to a minimum cross-sectional area Y (mm2) of the liquid feed-discharger in a direction orthogonal to an axial direction of the liquid feed-discharger is from 1 to 5.

Abstract: Particles including at least one base material and a physiologically active substance having physiological activity are useful. The physiologically active substance is contained and dispersed in the at least one base material, and the physiologically active substance has a property such that the physiological activity is changed by heating, cooling, or external stress.

Abstract: A nanoparticle includes a poorly-water-soluble physiologically active compound and an additive substance. A relative span factor (R.S.F) of the nanoparticle satisfies formula: 0<(R.S.F)?1.0, a volume average particle diameter of the nanoparticle is 200 nm or less, and the poorly-water-soluble physiologically active compound is covered with the additive substance.

Abstract: A method for manufacturing resin particles is provided. The method includes the steps of: dissolving a resin free of poly(lactic-co-glycolic acid) (PLGA) in a good solvent of the resin to prepare a resin solution; and discharging the resin solution from at least one discharge hole having an inner diameter of less than 1,000 ?m into a poor solvent of the resin to form resin particles.

Abstract: A pharmaceutical composition including particles each containing a water-soluble base material and a poorly water-soluble compound, the water-soluble base material containing a rapidly water-soluble compound, wherein the poorly water-soluble compound is a kinase inhibitor and exists in an amorphous state in the water-soluble base material.

Abstract: A particle-producing method is provided including the processes of: discharging a liquid from discharge holes provided on a liquid-storing unit storing the liquid to make the liquid into droplets, the liquid containing a physiologically active substance and a polymer; and solidifying the droplets into a particle.

Abstract: A particulate poly(lactic-co-glycolic) acid (PLGA) is provided. The particulate PLGA comprises a poly(lactic-co-glycolic) acid (PLGA), and has an average volume-based particle diameter of 80 nm or less and a relative span factor (R.S.F.) satisfying the following formula (1): 0 < R . S . F . ? 1.20 Formula ? ? ( 1 ) where R.S.F, is defined by (D90?D10)/D50, where D90, D50, and D10 respectively represent particle diameters at cumulative rates of 90%, 50%, and 10% by volume based on a cumulative particle size distribution counted from a small-particle side.

Abstract: An instantly soluble particle including: a water-soluble base material; and a poorly water-soluble compound, wherein the water-soluble base material contains a rapidly water-soluble compound, and the poorly water-soluble compound exists in the water-soluble base material in an amorphous state.

Abstract: Provided is a method for producing a particle including forming a particle composition liquid into droplets where the particle composition liquid includes a physiologically active substance and at least two dispersants, and solidifying the droplets of the particle composition liquid in a manner that at least one of the at least two dispersants is locally present at the surface side of the particle.

Abstract: Provided are sustained-release particles, each including a base material, and a physiologically active substance, wherein a ratio of a surface area of the sustained-release particles to a volume of the sustained-release particles is 0.6 or less.

Abstract: A method for producing particles, the method including: applying vibration to a liquid including a physiologically active substance and included in a liquid-column resonance liquid-chamber to form a standing wave based on liquid column resonance, to thereby discharge the liquid from at least one discharging port, which is formed in an amplitude direction of the standing wave, to at least one region corresponding to at least one anti-node of the standing wave; and drying the liquid discharged, to thereby form particles.

Abstract: A discharge device is provided. The discharge device includes a liquid feed-discharger, and the liquid feed-discharger includes a feed unit configured to feed a liquid and a discharge unit having discharge holes configured to discharge the liquid fed by the feed unit. A ratio (X/Y) of a maximum cross-sectional area X (mm2) to a minimum cross-sectional area Y (mm2) of the liquid feed-discharger in a direction orthogonal to an axial direction of the liquid feed-discharger is from 1 to 5.

Abstract: A method for manufacturing resin particles is provided. The method includes the steps of: dissolving a resin free of poly(lactic-co-glycolic acid) (PLGA) in a good solvent of the resin to prepare a resin solution; and discharging the resin solution from at least one discharge hole having an inner diameter of less than 1,000 ?m into a poor solvent of the resin to form resin particles.

Abstract: A particle-producing method is provided including the processes of: discharging a liquid from discharge holes provided on a liquid-storing unit storing the liquid to make the liquid into droplets, the liquid containing a physiologically active substance and a polymer; and solidifying the droplets into a particle.

Abstract: A particulate poly(lactic-co-glycolic) acid (PLGA) is provided. The particulate PLGA comprises a poly(lactic-co-glycolic) acid (PLGA), and has an average volume-based particle diameter of 80 nm or less and a relative span factor (R.S.F.) satisfying the following formula (1): 0<R.S.F.?1.20??Formula (1) where R.S.F. is defined by (D90?D10)/D50, where D90, D50, and D10 respectively represent particle diameters at cumulative rates of 90%, 50%, and 10% by volume based on a cumulative particle size distribution counted from a small-particle side.