Patents by Inventor Tadahiro Matsudaira

Tadahiro Matsudaira has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for suppressing an immunoresponse with an estradiol derivative-chlorambucil conjugate
    Patent number: 5578589
    Abstract: The invention is drawn to a method for suppressing an immunoresponse in animals by administering an estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: November 26, 1996
    Assignee: Kureha Chemical Industry Co., Ltd.
    Inventors: Fumio Tamura, Tsuyoshi Saito, Satoshi Mitsuhashi, Tadahiro Matsudaira, Kiro Asano
  • Estradiol derivative-chlorambucil conjugate, process for preparing the same, and pharmaceutical composition
    Patent number: 5576309
    Abstract: An estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different; a process for preparing the same, and a pharmaceutical composition containing the conjugate are described.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: November 19, 1996
    Assignee: Kureha Chemical Industry Co., Ltd.
    Inventors: Fumio Tamura, Tsuyoshi Saito, Satoshi Mitsuhashi, Tadahiro Matsudaira, Kiro Asano
  • Estradiol derivative-chlorambucil conjugate process for preparing the same, and pharmaceutical composition
    Patent number: 5354745
    Abstract: An estradiol derivative-chlorambucil conjugate of the formula (I): ##STR1## wherein R.sup.1 is alkyl or alkoxyl of 1 to 4 carbon atoms; R.sup.2 is acyl, dansyl, or alkyl; R.sup.3, R.sup.4, and R.sup.5 independently are H, oxo, OH, or acyloxy; m is an integer of 1 to 3; and n is an integer of 0 to 3; provided that when n is 0, all of R.sup.3, R.sup.4, and R.sup.5 are not H at the same time, and at least one of R.sup.3, R.sup.4, and R.sup.5 is a group other than H and OH; and further, when n is 2 or 3, the groups R.sup.1 are the same or different; a process for preparing the same, and a pharmaceutical composition containing the conjugate are described.
    Type: Grant
    Filed: June 3, 1993
    Date of Patent: October 11, 1994
    Assignee: Kureha Chemical Industry Co., Ltd.
    Inventors: Fumio Tamura, Tsuyoshi Saito, Satoshi Mitsuhashi, Tadahiro Matsudaira, Kiro Asano
  • Immunoregulator comprising a derivative of estradiol
    Patent number: 4885290
    Abstract: Disclosed herein is an immunoregulator comprising a derivative of estradiol represented by the formula (I), which immunoregulator has a small influence to the non-specific immunoreactions in general and gives a specific influence to the immunoreactions against an isoantibody.
    Type: Grant
    Filed: October 29, 1987
    Date of Patent: December 5, 1989
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Kiro Asano, Tadahiro Matsudaira, Humio Tamura, Toichi Suzuki, Hisayuki Wada