Patents by Inventor Tadahito Takahashi
Tadahito Takahashi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9862992Abstract: A substrate surface on which either a substance to detect analyte or an analyte per se is immobilized, which surface is formed by a treatment of substrate surface with a liquid which contains uncrosslinked polymer based on polyethylene glycol chain segment, said treatment conducted either simultaneously with the immobilization of said substance or analyte or after said substance or analyte has been immobilized on said surface. The non-specific adsorption of impurity protein or the like which is co-existent in sample for assay is significantly restrained.Type: GrantFiled: August 14, 2014Date of Patent: January 9, 2018Assignee: JSR CORPORATIONInventors: Yukio Nagasaki, Tadahito Takahashi, Kazunori Kataoka, Fumiko Aboshi, Miki Kato, Tomoko Jomura, Hiroshi Kobayashi, Yoshinori Katsuyama, Masami Nakamae
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Publication number: 20140378346Abstract: A substrate surface on which either a substance to detect analyte or an analyte per se is immobilized, which surface is formed by a treatment of substrate surface with a liquid which contains uncrosslinked polymer based on polyethylene glycol chain segment, said treatment conducted either simultaneously with the immobilization of said substance or analyte or after said substance or analyte has been immobilized on said surface. The non-specific adsorption of impurity protein or the like which is co-existent in sample for assay is significantly restrained.Type: ApplicationFiled: August 14, 2014Publication date: December 25, 2014Inventors: Yukio NAGASAKI, Tadahito TAKAHASHI, Kazunori KATAOKA, Fumiko ABOSHI, Miki KATO, Tomoko JOMURA, Hiroshi KOBAYASHI, Yoshinori KATSUYAMA, Masami NAKAMAE
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Patent number: 8841138Abstract: A substrate surface on which either a substance to detect analyte or an analyte per se is immobilized, which surface is formed by a treatment of substrate surface with a liquid which contains uncrosslinked polymer based on polyethylene glycol chain segment, said treatment conducted either simultaneously with the immobilization of said substance or analyte or after said substance or analyte has been immobilized on said surface. The non-specific adsorption of impurity protein or the like which is co-existent in sample for assay is significantly restrained.Type: GrantFiled: July 28, 2004Date of Patent: September 23, 2014Assignee: JSR CorporationInventors: Yukio Nagasaki, Tadahito Takahashi, Kazunori Kataoka, Fumiko Aboshi, Miki Kato, Tomoko Jomura, Hiroshi Kobayashi, Yoshinori Katsuyama, Masami Nakamae
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Patent number: 7732158Abstract: This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.Type: GrantFiled: September 6, 2004Date of Patent: June 8, 2010Assignee: Japan Science and Technology AgencyInventors: Yukio Nagasaki, Kazunori Kataoka, Takehiko Ishii, Tadahito Takahashi
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Publication number: 20070172444Abstract: There is provided a hair tonic comprising at least two of an inhibitor against 5? reductase type 2, an inhibitor against transforming growth factor ?2, and an inhibitor against caspase-3; a method comprising screening for at least two of inhibition against 5? reductase type 2, inhibition against transforming growth factor ?2, and inhibition against caspase-3, or comprising screening for inhibition against caspase-3 and then for apoptosis inhibition, and a hair loss inhibitor having the effect of inhibiting caspase-3, and a hair loss inhibitor having the effect of inhibiting caspase-3 and of inhibiting apoptosis.Type: ApplicationFiled: January 4, 2007Publication date: July 26, 2007Applicant: Shiseido Company, Ltd.Inventors: Toshihiko Hibino, Yumiko Tsuji, Tsutomu Soma, Sumiko Denda, Jotaro Nakanishi, Tadahito Takahashi, Kenichi Umishio, Koji Kobayashi
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Patent number: 7214500Abstract: A surface on which adsorption of protein (e.g., BSA) is markedly suppressed is provided, by contacting solutions of polymers whose chief component is poly(ethylene oxide) having binding sites to sensor surfaces with biosensor surfaces plural times to link the polymers.Type: GrantFiled: March 7, 2003Date of Patent: May 8, 2007Assignee: Toudai TLO, Ltd.Inventors: Kazunori Kataoka, Yukio Nagasaki, Hidenori Otsuka, Katsumi Uchida, Tadahito Takahashi, Miki Kato
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Publication number: 20070059843Abstract: This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.Type: ApplicationFiled: September 6, 2004Publication date: March 15, 2007Inventors: Yukio Nagasaki, Kazunori Kataoka, Takehiko Ishii, Tadahito Takahashi
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Publication number: 20060240438Abstract: A substrate surface on which either a substance to detect analyte or an analyte per se is immobilized, which surface is formed by a treatment of substrate surface with a liquid which contains uncrosslinked polymer based on polyethylene glycol chain segment, said treatment conducted either simultaneously with the immobilization of said substance or analyte or after said substance or analyte has been immobilized on said surface. The non-specific adsorption of impurity protein or the like which is co-existent in sample for assay is significantly restrained.Type: ApplicationFiled: July 28, 2004Publication date: October 26, 2006Inventors: Yukio Nagasaki, Tadahito Takahashi, Kazunori Kataoka, Fumiko Aboshi, Miki Kato, Tomoko Jomura, Hiroshi Kobayashi, Yoshinori Katsuyama, Masami Nakamae
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Publication number: 20060159715Abstract: A conjugate which comprises fine porous particles (on which functional substance may be adhered) and a polymer based on water-soluble high molecular chain segment, and the use of the conjugate (for the purpose of stably supporting, or slowly releasing, a physiologically active substance, or the like).Type: ApplicationFiled: July 9, 2004Publication date: July 20, 2006Inventors: Yukio Nagasaki, Tadahito Takahashi, Kazunori Kataoka, Yoshiaki Yamada
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Publication number: 20060153794Abstract: There is provided a hair tonic comprising at least two of an inhibitor against 5? reductase type 2, an inhibitor against transforming growth factor ?2, and an inhibitor against caspase-3; a method comprising screening for at least two of inhibition against 5? reductase type 2, inhibition against transforming growth factor ?2, and inhibition against caspase-3, or comprising screening for inhibition against caspase-3 and then for apoptosis inhibition, and a hair loss inhibitor having the effect of inhibiting caspase-3, and a hair loss inhibitor having the effect of inhibiting caspase-3 and of inhibiting apoptosis.Type: ApplicationFiled: December 21, 2005Publication date: July 13, 2006Applicant: Shiseido Company, Ltd.Inventors: Toshihiko Hibino, Yumiko Tsuji, Tsutomu Soma, Sumiko Denda, Jotaro Nakanishi, Tadahito Takahashi, Kenichi Umishio, Koji Kobayashi
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Publication number: 20060100367Abstract: This invention provides latex particles wherein non-specific adsorption or binding of undesired impurities which usually accompanies the use of latex particles is inhibited, and a process to produce such latex particles. This invention also provides diagnostic agent which contains said particles. In another embodiment, this invention provides latex particles comprising both a ligand group-holding site which has a ligand group on the one terminal and is bound, on the other terminal, to latex particles, and which has a long chain of polyoxyethylene; and a non-specific adsorption-inhibiting site which is bound, at one terminal, to latex particles, and which has a short chain of polyoxyethylene. In this embodiment, this invention also provides a process to produce said particles.Type: ApplicationFiled: December 19, 2003Publication date: May 11, 2006Inventors: Yukio Nagasaki, Kazunori Kataoka, Tadahito Takahashi, Hidenori Otsuka, Noriyuki Ito, Kouichiro Ishigaki
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Publication number: 20050142028Abstract: A surface on which adsorption of protein (e.g., BSA) is markedly suppressed is provided, by contacting solutions of polymers whose chief component is poly(ethylene oxide) having binding sites to sensor surfaces with biosensor surfaces plural times to link the polymers.Type: ApplicationFiled: March 7, 2003Publication date: June 30, 2005Inventors: Kazunori Kataoka, Yukio Nagasaki, Hidenori Otsuka, Katsumi Uchida, Tadahito Takahashi
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Patent number: 6818214Abstract: A method of modulating cell proliferation or apoptosis comprising modulating psoriastatin activity.Type: GrantFiled: October 16, 1996Date of Patent: November 16, 2004Assignees: The General Hospital Corporation, Shiseido Co., Ltd.Inventors: Toshihiko Hibino, Tadahito Takahashi, Peter C. Baciu, Paul F. Goetinck
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Publication number: 20040022758Abstract: There is provided a hair tonic comprising at least two of an inhibitor against 5&agr; reductase type 2, an inhibitor against transforming growth factor &bgr;2, and an inhibitor against caspase-3; a method comprising screening for at least two of inhibition against 5&agr; reductase type 2, inhibition against transforming growth factor &bgr;2, and inhibition against caspase-3, or comprising screening for inhibition against caspase-3 and then for apoptosis inhibition, and a hair loss inhibitor having the effect of inhibiting caspase-3, and a hair loss inhibitor having the effect of inhibiting caspase-3 and of inhibiting apoptosis.Type: ApplicationFiled: March 6, 2003Publication date: February 5, 2004Inventors: Toshihiko Hibino, Yumiko Tsuji, Tsutomu Soma, Sumiko Denda, Jotaro Nakanishi, Jotaro Nakanishi, Tadahito Takahashi, Kenichi Umishio, Koji Kobayashi
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Publication number: 20030198614Abstract: The present invention provides a hair growth promoting composition having an excellent hair growth promoting effect.Type: ApplicationFiled: February 24, 2003Publication date: October 23, 2003Inventors: Tadahito Takahashi, Yosuke Nakazawa, Takayuki Arai, Tokuro Iwabuchi, Tsunao Magara, Hirotada Fukunishi, Koji Kobayashi, Masahiro Tajima, Shigeo Ohno, Hiroshi Handa
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Publication number: 20030072752Abstract: A method of modulating cell proliferation or apoptosis comprising modulating psoriastatin activity.Type: ApplicationFiled: October 16, 1996Publication date: April 17, 2003Applicant: General Hospital Corporation, a Massachusetts corporationInventors: TOSHIHIKO HIBINO, TADAHITO TAKAHASHI, PETER C. BACIU, PAUL F. GOETINCK
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Publication number: 20030003071Abstract: The present invention provides a hair growth agent and a hair fostering shampoo that have N-methyltaurine as an essential ingredient, and have hair growth period extending effects, and moreover are capable of giving hair fitness and body and giving hair a feeling of volume. Moreover, the present invention also provides a cell activating agent and a hair fitness/body improving agent that are blended into hair cosmetics.Type: ApplicationFiled: June 25, 2002Publication date: January 2, 2003Inventors: Chika Hamada, Tadahito Takahashi, Masahiro Tajima, Yasunari Nakama, Tsunao Magara
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Patent number: 6120765Abstract: Purified uPA peptides having, mitogenic activity and containing as few as six amino acids of the EGF-like domain of uPA.Type: GrantFiled: October 25, 1993Date of Patent: September 19, 2000Assignee: Shiseido Co. Ltd.Inventors: Toshihiko Hibino, Tadahito Takahashi, Izumi Horii, Paul F. Goetinck
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Patent number: 5538728Abstract: A complex material of a hydrophilic polymer-silicate mineral comprising a carboxyl group containing hydrophilic polymer and a water swellable silicate mineral, and having a new absorption spectrum not existing in both starting materials in the IR-ray absorption spectrum within the range of 1000 to 1300 cm.sup.-1, and pharmaceutical and cosmetic compositions comprising same.Type: GrantFiled: April 14, 1993Date of Patent: July 23, 1996Assignee: Shiseido Company, Ltd.Inventors: Toshio Yanaki, Tadahito Takahashi, Yoko Nagasawa, Michihiro Yamaguchi