Patents by Inventor Tadanori Morikawa

Tadanori Morikawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aminoketone asymmetric reductase and nucleic acid thereof
    Patent number: 7166452
    Abstract: A protein, which is an aminoketone asymmetric reductase, having an effect of producing d-pseudoephedrine by acting on 1-2-methylaminopropiophenone, and having the following physiochemical properties: substrate: 1-2-methylaminopropiophenone optimum pH: pH 8.1 optimum temperature: 55° C. coenzyme: NADP molecular weight: about 28500 Da homotetramer and a nucleic acid coding the protein.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: January 23, 2007
    Assignee: Daiichi Fine Chemical Co., Ltd.
    Inventors: Keiji Sakamoto, Shinji Kita, Kazuya Tsuzaki, Tadanori Morikawa, Sakayu Shimizu, Michihiko Kataoka
  • Process for the production of optically active &bgr;-amino alcohols
    Patent number: 6835559
    Abstract: A process for producing an optical active &bgr;-amino alcohol, the method comprising the step of allowing at least one microorganism selected from the group consisting of microorganisms belonging to the genus Morganella and others, to act on an enantiomeric mixture of an &agr;-aminoketone or a salt thereof having the general formula (I): to produce an optical active &bgr;-amino alcohol with the desired optical activity having the general formula (II) described below in a high yield as well as in a highly selective manner:
    Type: Grant
    Filed: January 22, 2003
    Date of Patent: December 28, 2004
    Assignee: Daiichi Fine Chemical Co., Ltd.
    Inventors: Keiji Sakamoto, Shinji Kita, Kazuya Tsuzaki, Tadanori Morikawa, Sakayu Shimizu, Michihiko Kataoka
  • Aminoketone asymmetric reductase and nucleic acid thereof
    Publication number: 20040247583
    Abstract: A protein, which is an aminoketone asymmetric reductase, having an effect of producing d-pseudoephedrine by acting on l-2-methylaminopropiophenone, and having the following physiochemical properties:
    Type: Application
    Filed: September 2, 2003
    Publication date: December 9, 2004
    Inventors: Keiji Sakamoto, Shinji Kita, Kazuya Tsuzaki, Tadanori Morikawa, Sakayu Shimizu, Michihiko Kataoka
  • Process for the production of optically active beta-amino alcohols
    Publication number: 20040091981
    Abstract: A process for producing an optical active &bgr;-amino alcohol, the method comprising the step of allowing at least one microorganism selected from the group consisting of microorganisms belonging to the genus Morganella and others, to act on an enantiomeric mixture of an &agr;-aminoketone or a salt thereof having the general formula (I): 1
    Type: Application
    Filed: January 22, 2003
    Publication date: May 13, 2004
    Inventors: Keiji Sakamoto, Shinji Kita, Kazuya Tsuzaki, Tadanori Morikawa, Sakayu Shimizu, Michihiko Kataoka
  • Highly water-soluble metalloproteinase inhibitors
    Patent number: 6284914
    Abstract: New compounds of general formulae (III), (IV) and (V).
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: September 4, 2001
    Assignee: Fuji Yakuhin Kogyo Kabushiki Kaisha
    Inventors: Junko Fujisawa, Eiko Suda, Katsuhiro Igeta, Tadanori Morikawa, Tetsunori Fujisawa, Shinjiro Odake, Yasuo Morita, Tomoko Hongo, Hajime Ito
  • Highly water-soluble metalloproteinase inhibitors
    Patent number: 6147114
    Abstract: New compounds of the general formula (I) ##STR1## (wherein R.sup.1 is a hydrogen atom, or a hydroxyl, aryl (C.sub.1 -C.sub.6)alkylene or --A--SOn--B group (A is a (C.sub.1 -C.sub.6) alkylene group; B is a (C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.6) acyl, aryl or heterocyclyl group; n is 0, 1 or 2), R.sup.2 is a hydrogen atom, or a (C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.6) alkyloxy 10 or (C.sub.1 -C.sub.6) alkylthio group, R.sup.3 and R.sup.4 are identical or different, representing a hydrogen atom, or a (C.sub.1 -C.sub.6) alkyl, aryl or aryl(C.sub.1 -C.sub.6)alkylene group, R.sup.5 is a --Y--C or C group (Y is a (C.sub.1 -C.sub.6) alkylene group, an oxygen atom, an imino group or a (C.sub.1 -C.sub.6) alkyleneimino group, C is a sulfonic acid, phosphonic acid, amidino, (C.sub.1 -C.sub.6) acyl, acylimidoyl, diphosphonomethine or dicarboxymethine group), and R.sup.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: November 14, 2000
    Assignee: Fuji Yakuhin Kogyo Kabushiki Kaisha
    Inventors: Tetsunori Fujisawa, Shinjiro Odake, Yasuo Morita, Tomoko Hongo, Hajime Ito, Junko Yasuda, Eiko Suda, Katsuhiro Igeta, Tadanori Morikawa
  • Anticoagulant hirudin variants and methods for their production
    Patent number: 5880258
    Abstract: The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients.Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated.Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients.Phe-Glu-A-Ile-Pro-D-Tyr(R) Tyr(R) (I)?In the formula, A represents Glu or Pro, R represents Glu, Tyr (R), Glu-Asp or Glu-Tyr(R), and (R) represents the hydroxy group or its sulfated ester (--O--SO.sub.3 H) of tyrosine residue.
    Type: Grant
    Filed: August 12, 1997
    Date of Patent: March 9, 1999
    Assignees: Japan Energy Corporation, Fuji Yakuhin Kogyo Kabushiki Kaisha
    Inventors: Ryo Muramatsu, Akiko Sukesada, Satoru Misawa, Eriko Nukui, Koichi Wada, Masaharu Nakano, Tadanori Morikawa, Kyoichi Kobashi
  • Anticoagulant hirudin variants and methods for their production
    Patent number: 5767235
    Abstract: The present invention relates to hirudin variants having high anti-thrombin and anti-platelet activity, methods for producing them, and anti-coagulants having said variants as active ingredients.Hirudin variants shown in formula (I) having tyrosine residues or having their hydroxyl group sulfated.Methods for producing hirudin variants by sulfating hydroxyl group of said tyrosine residues, and anti-coagulants having hirudin variants shown in formula (I) as active ingredients.Phe-Glu-A-Ile-Pro-B-Tyr(R)-Tyr(R) (I)?In the formula, A represents Glu or Pro, B represents Glu, Tyr (R), Glu-Asp or Glu-Tyr(R), and (R) represents the hydroxy group or its sulfated ester (--O--SO.sub.3 H) of tyrosine residue.
    Type: Grant
    Filed: January 3, 1995
    Date of Patent: June 16, 1998
    Assignees: Nippon Mining Company Limited, Fuji Yakuhin Kogyo Kabushiki Kaisha
    Inventors: Eriko Nukui, Koichi Wada, Masaharu Nakano, Tadanori Morikawa, Kyoichi Kobashi, Ryo Muramatsu, Akiko Sukesada, Satoru Misawa
  • Hydroxamic acid tetrapeptide derivatives
    Patent number: 5100874
    Abstract: New peptide derivatives of which utility in the treatment of such diseases as rheumatoid arthritis, peridental diseases, corneal ulcer and epidermolysis bullosa is expected. These compounds are hydroxamic acid derivatives of tetrapeptides having a specific inhibitory activity against collagenase derived from vertebrates.
    Type: Grant
    Filed: August 4, 1989
    Date of Patent: March 31, 1992
    Assignee: Fuji Yakuhin Kogyo Kabushiki Kaisha
    Inventors: Shinjiro Odake, Toru Okayama, Masami Obata, Tadanori Morikawa, Yutaka Nagai
  • Polypeptides and process for producing the same
    Patent number: 4086221
    Abstract: Polypeptides of the formula ##STR1## wherein A.sub.1 is Ser or Gly, A.sub.7 is Val or Met, A.sub.10 is Lys or Thr, A.sub.11 is Leu or Tyr, A.sub.12 is Ser or Thr, A.sub.14 is Glu or Asp, A.sub.15 is Leu or Phe, A.sub.16 is His or Asn, A.sub.18 is Leu or Phe, A.sub.19 is Gln or His, A.sub.21 is Tyr or Phe, A.sub.23 is Arg or Gln, A.sub.25 is Asp or Asn or Ala, A.sub.26 is Val or Thr or Ile, A.sub.28 is Ala or Ser or Val, and A.sub.30 is Thr or Val or Ala, and pharmaceutically acceptable acid addition salts and complexes, have serum calcium reducing activity.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: April 25, 1978
    Assignee: Toyo Jozo Kabushiki Kaisha
    Inventors: Shumpei Sakakibara, Tadanori Morikawa, Eisuke Munekata, Terutoshi Kimura, Yasuo Nakagawa, Toshiharu Noda
  • EEL calcitonin
    Patent number: 3988309
    Abstract: A polypeptide having calcitonin activity of the formula ##EQU1## and the salts thereof with pharmaceutically acceptable acids.
    Type: Grant
    Filed: December 17, 1974
    Date of Patent: October 26, 1976
    Assignee: Toyo Jozo Kabushiki Kaisha
    Inventors: Tetsuo Matsuda, Susumu Watanabe, Shunpei Sakakibara, Eisuke Munekata, Tadanori Morikawa, Masaru Otani, Toshiharu Noda, Hirose Yamauchi, Tosio Meguro, Shuichi Kitazawa