Abstract: A medical instrument in which an inorganic salt solid such as apatite into which a peptide hormone or the like is embedded is placed so that a metal or the like is coated therewith, in which the inorganic salt solid is provided by controlled delay co-precipitation or the like in an unstable supersaturated calcium phosphate solution, and the medical instrument is exposed to ionizing radiation at a dose sufficient for sterilization.

Abstract: A medical instrument in which an inorganic salt solid such as apatite into which a peptide hormone or the like is embedded is placed so that a metal or the like is coated therewith, in which the inorganic salt solid is provided by controlled delay co-precipitation or the like in an unstable supersaturated calcium phosphate solution, and the medical instrument is exposed to ionizing radiation at a dose sufficient for sterilization.

Abstract: A complex comprising a carrier containing a plasma-derived protein or serum-derived protein solidified by denaturation coagulation, and a protein having a peroxidase-like activity and carried by the carrier, which has such high effectiveness that it can strongly stimulate an antigen-presenting cell, and can be used as a highly safe immunostimulant with reduced toxicity to living bodies.

Abstract: A tumor vaccine for use in combination with a photodynamic therapy for a malignant tumor, which contains a tumor antigen derived from a tumor tissue separated from a patient to whom the photodynamic therapy is to be applied.

Abstract: A complex comprising a carrier containing a plasma-derived protein or serum-derived protein solidified by denaturation coagulation, and a protein having a peroxidase-like activity and carried by the carrier, which has such high effectiveness that it can strongly stimulate an antigen-presenting cell, and can be used as a highly safe immunostimulant with reduced toxicity to living bodies.

Abstract: An immunoadjuvant comprising one kind or two or more kinds of immunostimulating substances carried separately by two or more kinds of different microparticle immunostimulating substance carriers, and comprising at least a combination of (a) an inorganic substance such as microparticle calcium phosphate having a size phagocytizable by cells, and (b) precipitates of a soluble protein and a mucopolysaccharide formed by coacervation as the microparticle immunostimulating substance carriers, which is highly safe and can exhibit potent immunoadjuvant activity.

Abstract: An immunoadjuvant comprising one kind or two or more kinds of immunostimulating substances carried separately by two or more kinds of different microparticle immunostimulating substance carriers, and comprising at least a combination of (a) an inorganic substance such as microparticle calcium phosphate having a size phagocytizable by cells, and (b) precipitates of a soluble protein and a mucopolysaccharide formed by coacervation as the microparticle immunostimulating substance carriers, which is highly safe and can exhibit potent immunoadjuvant activity.

Abstract: A tumor vaccine which comprises a microparticle or a lysate prepared from a solidified tumor material selected from the group consisting of a tumor tissue, a tumor cell, and a component thereof, and at least one cytokine and/or cytokine-inducing agent (e.g., a granulocyte-macrophage-colony stimulating factor and/or interleukin-2 and the like), and optionally an adjuvant. The vaccine can be easily prepared and widely applied for prevention of recurrence, inhibition of metastasis and therapeutic treatment regardless of a type of a tumor, and has excellent antitumor effect.

Abstract: The object of the present invention is to provide a method of purifying reduced coenzyme Q10 to produce a high-quality product which is useful as an ingredient in foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks, feeds, cosmetics, medicines, remedies, preventive drugs, etc., by a efficient manner suitable for an industrial scale production. The present invention relates to a method of purifying reduced coenzyme Q10 which comprises washing crystals and/or oil of reduced coenzyme Q10 with a water-soluble organic solvent or a mixed solvent composed of a water-soluble organic solvent and water to thereby remove water-soluble impurities, especially a reducing agent or impurities derived from a reducing agent, from the crystals and/or oil of reduced coenzyme Q10.

Abstract: An immunoadjuvant which can efficiently exhibit potent adjuvant activity and avoid conditions undesirable for living bodies, and comprises precipitates formed by coacervation of (a) a soluble protein (provided that a soluble protein contained in tuberculin is excluded), and (b) a mucopolysaccharide, and further comprises (c) a soluble protein contained in tuberculin wherein said (c) is coprecipitated with the precipitates.

Abstract: An immunoadjuvant, having a potent cell-stimulating effect and highly safe for living bodies, which comprises a fragment, wherein said fragment is prepared from a solidified material selected from the group consisting of a tissue and a cell of an animal including a human and an ingredient thereof, and from which fragment a soluble ingredient is removed by washing with an organic solvent and/or hot water, and wherein a soluble ingredient derived from a microorganism is immobilized to said fragment.

Abstract: A method for implanting cells derived from a living body as living cells onto a surface of a three-dimensional structure having a complicated configuration such as teeth, dental implants, artificial bones and artificial vessels, which comprises the steps of: (a) preparing a mold matching a configuration of a surface of the three-dimensional structure, and (b) introducing a suspension of the cells into the mold, and then fitting the three-dimensional structure into the mold for incubation, and a three-dimensional structure having a surface on which cells derived from a living body are implanted as living cells, which is obtainable by the method.

Abstract: An anchorage-dependent cell, which is characterized to be introduced with a detection means, for stimulation of proliferation of a human natural killer cell, and a method for expansion culture of a human natural killer cell by using the aforementioned cell. The cell has a stimulatory action on proliferation of a human natural killer cell and/or a human natural killer precursor cell and is highly sensitive to the human natural killer cell obtained by the expansion culture.

Abstract: A process for an induction culture of a cytotoxic T lymphocyte having cell killing activities against a tumor cell which comprises the step of coculturing a tumor tissue containing said tumor cell and a lymphocyte of autologous peripheral blood obtained from a subject from which the tumor tissue is derived. The process is convenient since no separation and pure culture of tumor cells is required. The resulting cytotoxic T lymphocyte cells are useful for clinical treatments of tumors, e.g. adoptive immunotherapies.