Patents by Inventor Tadao Shishido
Tadao Shishido has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5861424Abstract: A pharmaceutical composition for treatment of cancer in a mammal comprising:(A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formulas (1) to (6) ##STR1## wherein X.sub.1 is O, S, Se, or >N--R.sub.14, ##STR2## X.sub.2 is O, S, Se, >N--R.sub.15, X.sub.3 is O, S, Se, ##STR3## X.sub.4 is >N--R.sub.19, or Y.sub.1 is O, S, Se, or >N--R.sub.18 ;Z.sub.1 represents an atomic group necessary to form a saturated or unsaturated 5- or 6-membered ring which may be substituted or may have another ring fused therewith;Z.sub.2 is a naphthalene ring, an anthracene ring or a phenanthrene ring which may be substituted; in combination with(B) a pharmaceutically acceptable carrier or diluent; and a method for treatment of cancer comprising administering the above pharmaceutical composition to a host afflicted with cancer.Type: GrantFiled: June 7, 1995Date of Patent: January 19, 1999Assignees: Dana Farber Cancer Institute, Fuji Photo Film Co., Ltd.Inventors: Lan Bo Chen, Tadao Shishido
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Patent number: 5670530Abstract: An anti-cancer composition comprising a rhodacyanine compound and cyclodextrin or derivative thereof, wherein said rhodacyanine compound is selected from the group consisting of compounds represented by the following Formula (I), the cation moiety of which has a log P value of 4.5-12: ##STR1## wherein X.sub.1 and X.sub.2, which may be the same or different, each represents O, S, Se, ##STR2## Y.sub.1 represents O, S, Se, or ##STR3## R.sub.1 and R.sub.3, which may be the same or different, each represents an alkyl group;R.sub.2 represents an alkyl group, an aryl group or a heterocyclic group;Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring;L.sub.1, L.sub.2 and L.sub.3, which may be the same or different, each represents a methine group or nitrogen atom and L.sub.1 and R.sub.3 may combine and form a 5- or 6-membered ring;R.sub.4 and R.sub.5, which may be the same or different, each represents an alkyl group;R.sub.6 and R.sub.Type: GrantFiled: June 7, 1995Date of Patent: September 23, 1997Assignees: Fuji Photo Film Co., Ltd., Dana Farber Cancer InstituteInventors: Lan Bo Chen, Tadao Shishido
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Patent number: 5618831Abstract: A pharmaceutical composition for treatment of cancer in an animal comprising:(A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I). ##STR1## wherein Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring;R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, each represents an alkyl group or an aryl group;L.sub.1 and L.sub.2 each represents a methine group or a substituted methine group;X represents a pharmaceutically acceptable anion;k represents a number necessary for electrical charge balance;n represents 0 or 1; and(B) a pharmaceutically acceptable carrier or diluent.Type: GrantFiled: May 16, 1994Date of Patent: April 8, 1997Assignees: Fuji Photo Film Co., Ltd., Dana Farber Cancer InstituteInventors: Tadao Shishido, Masayuki Kawakami, Akihiko Ikegawa, Toshinao Ukai, Keizo Koya, Lan B. Chen
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Patent number: 5360803Abstract: A pharmaceutical composition for treatment of cancer comprises:(A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds represented by the General Formula (I) ##STR1## wherein X.sub.1 and X.sub.2, which may be the same or different, each represents O, S, Se, --CH.dbd.CH--, ##STR2## Y.sub.1 represents O, S, Se, or ##STR3## R.sub.1 and R.sub.3, which may be the same or different, each represents an alkyl group;R.sub.2 represents an alkyl group, an aryl group or a heterocyclic group;Z.sub.1 and Z.sub.2, which may be the same or different, each represents an atomic group necessary to form a 5- or 6-membered ring;L.sub.1 represents a methine group or L.sub.1 and R.sub.3 may combine and form a 5- or 6-membered ring;R.sub.4 and R.sub.5, which may be the same or different, each represents a alkyl group;R.sub.6 and R.sub.Type: GrantFiled: November 6, 1992Date of Patent: November 1, 1994Assignees: Dan Farber Cancer Institute, Fuji Photo Film Co., Ltd.Inventors: Tadao Shishido, Lan B. Chen
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Patent number: 5115337Abstract: A nonlinear optical material comprising a compound represented by formula (I) ##STR1## wherein Z.sup.1, Z.sup.2, R.sup.1, X and n are as defined before, or a compound represented by formula (II) ##STR2## wherein Z.sup.11 and Z.sup.12 are as defined before. The compounds of formulae (I) and (II) exhibits high transmittance to blue light and high nonlinear optical effects.Type: GrantFiled: October 16, 1990Date of Patent: May 19, 1992Assignee: Fuji Photo Film Co., Ltd.Inventors: Masaki Okazaki, Tadao Shishido, Seiiti Kubodera
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Patent number: 5015567Abstract: A silver halide photographic emulsion is subjected to sulfur or gold-sulfur sensitization in the presence of a combination of (1) at least one of an organic thioether compound or a tetrasubstituted thiourea and (2) a nitrogen-containing heterocyclic compound, to achieve the prevention of pressure desensitization and safelight aptitude deterioration.Type: GrantFiled: February 10, 1989Date of Patent: May 14, 1991Assignee: Fuji Photo Film Co., Ltd.Inventors: Shuzo Suga, Tadao Shishido, Hiroyuki Mifune, Yoshiro Kawashima
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Patent number: 4982112Abstract: A nonlinear optical material comprising a compound represented by formula (I) ##STR1## wherein Z.sup.1, Z.sup.2, R.sup.1, X and n are as defined before, or a compound represented by formula (II) ##STR2## wherein Z.sup.11 and Z.sup.12 are as defined before. The compounds of formula (I) and (II) exhibits high transmittance to blue light and high nonlinear optical effects.Type: GrantFiled: October 26, 1988Date of Patent: January 1, 1991Assignee: Fuji Photo Film Co., Ltd.Inventors: Masaki Okazaki, Tadao Shishido, Seiiti Kubodera
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Patent number: 4923794Abstract: A silver halide photographic material comprising silver halide emulsion including a telluroether compound of the formula (I):L.sub.1 --Te--L.sub.2 (I)wherein L.sub.1 and L.sub.2 each independently represents a substituted or unsubstituted aliphatic group which is substituted with at least one hydroxyl group, mercapto group, amino group, ether group, selenoether group, thioether group, ammonium group, sulfonyl group, carbamoyl group, carbonamido group, sulfamoyl group, sulfonamido group, acyloxy group, sulfonyloxy group, ureido group, thioureido group, thioamido group, oxysulfonyl group, oxycarbonylamino group, sulfonic acid group or salt thereof, phosphoric acid or salt thereof, phosphoric ester group, sulfinic acid group or a salt thereof, phosphino group or heterocyclic group.Type: GrantFiled: July 11, 1989Date of Patent: May 8, 1990Assignee: Fuji Photo Film Co., Ltd.Inventors: Hirotomo Sasaki, Tadao Shishido, Hiroyuki Mifune
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Patent number: 4873172Abstract: A process for forming a superhigh contrast negative image with a stable developer is disclosed, which comprises development processing a silver halide photographic material in the presence of a compound of formula (I) and a compound of formula (II) as defined in the specification.Type: GrantFiled: August 8, 1988Date of Patent: October 10, 1989Assignee: Fuji Photo Film Co., Ltd.Inventors: Shoji Ishiguro, Shigeo Hirano, Tadao Shishido, Akio Miyake
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Patent number: 4822891Abstract: Novel compounds are disclosed which are 4-amino-2,3-di-substituted-1-(mono- or trichlorophenyl)-3-pyrazolin-5-ones-representing by the following formulae (1) to (3); ##STR1## and acid addition salts thereof. The compounds can be easily produced and are useful for qualitative analysis or quantitative analysis of hydrogen peroxide when used as a component of a color indicator composition for detecting hydrogen peroxide.Type: GrantFiled: February 11, 1987Date of Patent: April 18, 1989Assignee: Fuji Photo Film Co., Ltd.Inventors: Yoshio Inagaki, Tadao Shishido
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Patent number: 4801524Abstract: A process for preparing a silver halide emulsion using a sulfur-containing inhibitor which substantially inhibits growth of silver halide grains is disclosed. The sulfur-containing inhibitor is inactivated by addition of an oxidizing agent capable of reducing or eliminating the inhibitory activity of the sulfur-containing inhibitor. By the process, adverse influences of the sulfur-containing inhibitor upon chemical ripening or development can be excluded.Type: GrantFiled: March 20, 1987Date of Patent: January 31, 1989Assignee: Fuji Photo Film Co., Ltd.Inventors: Hiroyuki Mifune, Tadao Shishido, Yoshiaki Suzuki
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Patent number: 4717648Abstract: A process for processing a silver halide color reversal photographic light-sensitive material is disclosed, which comprises developing an imagewise exposed silver halide color reversal photographic light-sensitive material with a black-and-white developer containing at least one compound selected from the compounds of Group A, at least one compound selected from the compounds of Group B, and preferably further at least one compound selected from the compounds of Group C, whereinGroup A consists of organic heterocyclic compounds represented by formulae (A-I), (A-II), (A-III), and (A-IV) ##STR1## Group B consists of benzoimidazole, indazole, benzotriazole, benzooxazole and benzothiazole compounds, not containing a thiol group, a thioether bond, a thioketone group, or a disulfide bond.Group C consists of compounds represented by formulae (C-I) and (C-II). ##STR2## wherein the symbols are as defined in the appended claims.Type: GrantFiled: February 7, 1986Date of Patent: January 5, 1988Assignee: Fuji Photo Film Co., Ltd.Inventors: Shinji Ueda, Junya Nakajima, Tadao Shishido, Sadanobu Shuto
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Patent number: 4713321Abstract: A process for preparing a silver halide photographic emulsion to be used for a photographic material is provided. Therein, additives such as dyes, sensitizers, auxiliary agents to be used upon gold sensitization, and so on are utilized within a period from at the silver halide grain forming time to just before the emulsion coating, and oxidizing agents are added at the time when the functions of the additives become substantially needless to result in conversion of the additives to those having no bad influences on photographic characteristics of the emulsion prepared, or to those having such chemical structures as to facilitate their removal with a washing treatment or the like.Silver halide emulsions prepared by the described process are also disclosed.Type: GrantFiled: February 14, 1986Date of Patent: December 15, 1987Assignee: Fuji Photo Film Co., Ltd.Inventors: Hiroyuki Mifune, Tadao Shishido, Yoshiaki Suzuki
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Patent number: 4711963Abstract: Compounds are disclosed which are 4-amino-2,3-di-substituted-1-(mono- or trichlorophenyl)-3-pyrazolin-5-ones represented by the following formulae (1) to (3): ##STR1## and acid addition salts thereof. The compounds can be easily produced and are useful for qualitative analysis or quantitative analysis of hydrogen peroxide when used as a component of a color indicator composition for detecting hydrogen peroxide.Type: GrantFiled: April 29, 1986Date of Patent: December 8, 1987Assignee: Fuji Photo Film Co., Ltd.Inventors: Yoshio Inagaki, Tadao Shishido
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Patent number: 4681838Abstract: A silver halide emulsion and a process for producing the same are disclosed. In the process, at least one compound selected from hydrogen peroxide or an adduct or precursor thereof, a peroxy acid salt, and ozone is added to an emulsion in the step prior to the end of chemical ripening. The emulsion exhibits reduced fog, improved stability with time, and improved sensitivity.Type: GrantFiled: June 14, 1985Date of Patent: July 21, 1987Assignee: Fuji Photo Film Co., Ltd.Inventors: Hiroyuki Mifune, Tadao Shishido, Yoshiaki Suzuki
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Process for preparing silver halide emulsion and silver halide photographic light-sensitive material
Patent number: 4665017Abstract: A process for preparing a silver halide emulsion wherein a sulfur-containing silver halide solvent which accelerates growth of silver halide grains and an oxidizing agent capable of reducing or eliminating the grain growth effect of the sulfur-containing silver halide solvent are used, and a silver halide photographic light-sensitive material containing the silver halide emulsion prepared by the process are disclosed. The grain growth effect of the sulfur-containing silver halide solvent can be controlled at any necessary stage without accompanying substantial deterioration in photographic properties.Type: GrantFiled: December 7, 1984Date of Patent: May 12, 1987Assignee: Fuji Photo Film Co., Ltd.Inventors: Hiroyuki Mifune, Tadao Shishido, Yoshiaki Suzuki -
Patent number: 4610954Abstract: A silver halide photographic light-sensitive material for obtaining a silver image comprising a water-impermeable support having at least one silver halide emulsion layer, and containing in association with the emulsion layer a compound selected from the group consisting of: (a) a compound represented by the following general formula (I): ##STR1## (b) a compound represented by the following general formula (II): ##STR2## and (c) a combination of a compound represented by the following general formula (III) and a compound represented by the following general formula (IV): ##STR3## (all the symbols are as defined in the appended claims), and a method of forming silver images using the above-defined silver halide photographic light-sensitive material, are disclosed.Type: GrantFiled: November 8, 1984Date of Patent: September 9, 1986Assignee: Fuji Photo Film Co., Ltd.Inventors: Masaaki Torigoe, Yoshio Inagaki, Tadao Shishido
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Patent number: 4418140Abstract: A process for the development of color photographic light-sensitive material is described. The process comprises color developing an exposed light-sensitive material in the presence of a compound of the general formula: ##STR1## wherein M is a hydrogen atom, an alkali metal atom, NH.sub.4 or a protective group for the mercapto group which undergoes cleavage by the action of an alkali; R is a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms; and R' is a hydrogen atom or an alkyl group containing 1 to 3 carbon atoms. This process prevents the formation of color development fog without seriously reducing sensitivity.Type: GrantFiled: April 8, 1982Date of Patent: November 29, 1983Assignee: Fuji Photo Film Co., Ltd.Inventors: Hiroyuki Mifune, Shoji Ishiguro, Tadao Shishido, Tatsuo Nishimura
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Patent number: 4418037Abstract: In a multilayer analysis film for detecting hydrogen peroxide by dry process which comprises a support and a reagent layer having contained therein a color indicator composition comprising peroxidase and a substance capable of causing a optically detectable change in the presence of hydrogen peroxide and peroxidase, the color indicator composition is characterized by further containing specific pyrogallol derivatives. Such pyrogallol derivatives improve stability during storage of such a multilayer analysis film.Type: GrantFiled: April 19, 1982Date of Patent: November 29, 1983Assignee: Fuji Photo Film Co., Ltd.Inventors: Harumi Katsuyama, Tadao Shishido
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Patent number: 4391900Abstract: A process for development-processing a silver halide photographic light-sensitive material is described, comprising processing with a developing solution containing 0.1 mol/liter or more of sulfite ion and at least one compound represented by formula (I) ##STR1## wherein n represents an integer of from 2 to 6; each of R.sub.1 and R.sub.2 represents hydrogen or an alkyl group having from 1 to 6 carbon atoms; and M represents hydrogen or an alkali metal atom.According to the process, the generation of silver sludge and the formation of fog are prevented when a black-and-white photographic light-sensitive material is processed with a developing solution containing sulfates in a high concentration.Type: GrantFiled: January 13, 1982Date of Patent: July 5, 1983Assignee: Fuji Photo Film Co., Ltd.Inventors: Takashi Toyoda, Tadao Shishido, Teruaki Tsujikawa