Patents by Inventor Tadashi Ashizawa
Tadashi Ashizawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190389780Abstract: Sanitary ware, including a ceramic base material, an upper glaze layer positioned on a surface of the ceramic base material, and an intermediate layer positioned between the ceramic base material and the upper glaze layer, wherein the sanitary ware satisfies at least one of the following conditions: a pore area ratio of 3% or less in terms of a ratio of an area of pores present in a cut surface obtained by cutting the upper glaze layer along the thickness direction thereof, relative to an area of the cut surface, an average pore size of 50 ?m or less as measured with respect to the cut surface obtained by cutting the upper glaze layer along the thickness direction thereof, and a difference of 50 ?m or less between the maximum and minimum values of the thickness of the upper glaze layer.Type: ApplicationFiled: June 17, 2019Publication date: December 26, 2019Applicant: LIXIL CorporationInventors: Toshinori MORI, Kazuo TAKEUCHI, Shunzou IWASAKI, Isao YOSHINAGA, Hiroyuki MIYAMOTO, Tadashi ASHIZAWA, Hideaki SAWADA, Jaehoon CHOI, Shuji KAWAI
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Publication number: 20190390449Abstract: The washbowl includes a bowl recessed downward, and comprising a ceramics base material, an intermediate layer disposed on a surface side of the ceramics base, and an upper glaze layer disposed on a surface side of the intermediate layer, the upper glaze layer being more transparent than the intermediate layer; and a drainage port. The bowl includes an inclined surface formed on a surface of the bowl and continuously recessed downward, the inclined surface formed at a position at least on a front side of the surface of the bowl when a user uses the bowl, the position being configured to be seen by the user, and the inclined surface is formed such that a tangent to the inclined surface is formed at 5 degrees to 75 degrees with respect to a horizontal plane.Type: ApplicationFiled: June 17, 2019Publication date: December 26, 2019Applicant: LIXIL CorporationInventors: Hiroshi KOBAYASHI, Toshinori MORI, Kazuo TAKEUCHI, Shunzou IWASAKI, Isao YOSHINAGA, Hiroyuki MIYAMOTO, Tadashi ASHIZAWA, Hideaki SAWADA, Jaehoon CHOI, Shuji KAWAI
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Patent number: 8796320Abstract: Provided is a 1,3,4-oxadiazole-2-carboxamide compound which has STAT3 inhibitory activity and is useful as an anticancer agent. Provided is a 1,3,4-oxadiazole-2-carboxamide compound represented by formula (I) or a pharmacologically acceptable salt thereof (in the formula, Ar represents a furyl group or the like; R1 represents a hydrogen atom or the like; and —X—Y represents a diaryl group such as a biphenyl group).Type: GrantFiled: December 28, 2010Date of Patent: August 5, 2014Assignees: General Incorporated Association Pharma Valley Project Supporting Organization, Pharma Design, Shizuoka Prefecture, Kumamoto Health Science University, Kabushiki Kaisha Yakult HonshaInventors: Akira Asai, Kenji Matsuno, Naohisa Ogo, Osamu Takahashi, Yoshiaki Masuda, Ayumu Muroya, Yasuto Akiyama, Tadashi Ashizawa, Tadashi Okawara
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Patent number: 8466290Abstract: The present invention provides a STATS inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and R1 to R8 and R34 each represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like), or a pharmacologically acceptable salt thereof.Type: GrantFiled: July 10, 2009Date of Patent: June 18, 2013Assignees: Pharma IP General Incorporated Association, Pharma Design, Inc., Shizuoka Prefecture, Kumamoto Health Science University, Kabushiki Kaisha Yakult HonshaInventors: Akira Asai, Kenji Matsuno, Naohisa Ogo, Takane Yokotagawa, Osamu Takahashi, Yasuto Akiyama, Tadashi Ashizawa, Tadashi Okawara
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Publication number: 20120302524Abstract: Provided is a 1,3,4-oxadiazole-2-carboxamide compound which has STAT3 inhibitory activity and is useful as an anticancer agent. Provided is a 1,3,4-oxadiazole-2-carboxamide compound represented by formula (I) or a pharmacologically acceptable salt thereof (in the formula, Ar represents a furyl group or the like; R1 represents a hydrogen atom or the like; and —X—Y represents a diaryl group such as a biphenyl group).Type: ApplicationFiled: December 28, 2010Publication date: November 29, 2012Applicants: GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION, PHARMA DESIGN, INC., KABUSHIKI KAISHA YAKULT HONSHA, KUMAMOTO HEALTH SCIENCE UNIVERSITY, SHIZUOKA PREFECTUREInventors: Akira Asai, Kenji Matsuno, Naohisa Ogo, Osamu Takahashi, Yoshiaki Masuda, Ayumu Muroya, Yasuto Akiyama, Tadashi Ashizawa, Tadashi Okawara
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Publication number: 20110172429Abstract: The present invention provides a STATS inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and R1 to R8 and R34 each represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like.), or a pharmacologically acceptable salt thereof.Type: ApplicationFiled: July 10, 2009Publication date: July 14, 2011Applicants: PHARMA IP GENERAL INCORPORATED ASSOCIATION, PHARMA DESIGN, INC., SHIZUOKA PREFECTURE, KUMAMOTO HEALTH SCIENCE UNIVERSITY, KABUSHIKI KAISHA YAKULT HONSHAInventors: Akira Asai, Kenji Matsuno, Naohisa Ogo, Takane Yokotagawa, Osamu Takahashi, Yasuto Akiyama, Tadashi Ashizawa, Tadashi Okawara
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Patent number: 6492392Abstract: The present invention provides 2-piperidone compounds or pharmaceutically acceptable salts thereof, which have a potent activity of inhibiting the proliferation of tumor cells and thus are useful as medicaments, as well as antitumor agents containing these compounds. The 2-piperidone compound is represented by the following formula (I): wherein R1 represents —(CH2)nR1a {wherein n is an integer of from 0 to 5, and R1a represents amino, lower alkylamino, di(lower alkyl)amino, substituted or unsubstituted aryl, or a substituted or unsubstituted heterocyclic group}, and R2 and R3 independently represent lower alkyl which may be substituted by lower alkoxycarboyl; lower alkenyl, aralkyl or lower alkynyl which may be substituted by substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group; substituted or unsubstituted aryl; or a substituted or unsubstituted heterocyclic group.Type: GrantFiled: January 12, 2000Date of Patent: December 10, 2002Assignees: Kyowa Hakko Kogyo Co., Ltd., Eli Lilly & Co.Inventors: Yutaka Kanda, Rieko Tanaka, Mitsunobu Hara, Jun Eishima, Shiro Akinaga, Tadashi Ashizawa
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Patent number: 6080771Abstract: DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided: ##STR1## wherein R.sup.1 represents CO(CR.sup.4A R.sup.4B).sub.n1 (O(CH.sub.2).sub.p1).sub.n2 OR.sup.5 {wherein n1 represents an integer of 1 or 2; R.sup.4A and R.sup.4B are the same or different, and each represents hydrogen or lower alkyl; p1 and n2 each represents an integer of 1 to 10; and R.sup.Type: GrantFiled: August 13, 1998Date of Patent: June 27, 2000Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yutaka Kanda, Hitoshi Arai, Hiroyuki Yamaguchi, Tadashi Ashizawa, Shun-ichi Ikeda, Chikara Murakata, Tatsuya Tamaoki
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Patent number: 5981558Abstract: DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided: ##STR1## wherein R.sup.1 represents hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR.sup.4, or the like; R.sup.2 represents hydrogen or COR.sup.6 ; R.sup.3 represents --CH.sub.2 OCOR.sup.7, phthalimidomethyl, or the like; and W represents oxygen or NR.sup.8 (wherein R.sup.8 represents hydroxy, lower alkoxy, lower alkenyloxy, aralkyloxy, substituted or unsubstituted arylsulfonylamino, or lower alkoxycarbonylamino).Type: GrantFiled: August 13, 1998Date of Patent: November 9, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hitoshi Arai, Yutaka Kanda, Hiroyuki Yamaguchi, Tadashi Ashizawa, Chikara Murakata, Shun-ichi Ikeda, Tatsuya Tamaoki
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Patent number: 5972997Abstract: The present invention relates to UCT1072 compounds represented by formula (I): wherein R.sup.1 and R.sup.2 together represent --CH(OH)CH.sub.2 O-- or --CH.sub.2 CH.sub.2 CH(OH)CH.sub.2 --.Type: GrantFiled: October 3, 1997Date of Patent: October 26, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tamio Mizukami, Akira Asai, Katsuhiko Ando, Shingo Kakita, Akira Mihara, Katsunori Kita, Yasuhiro Suzuki, Tadashi Ashizawa
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Patent number: 5952355Abstract: The present invention relates to propenone derivatives represented by the following formula (I): ##STR1## wherein R.sup.1 represents hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or YR.sup.5 (wherein Y represents S or O; and R.sup.5 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or a substituted or unsubstituted cyclic ether residue); R.sup.2 and R.sup.3 independently represent hydrogen, lower alkyl, or substituted or unsubstituted aralkyl, or alternatively R.sup.2 and R.sup.3 are combined to form substituted or unsubstituted methylene or ethylene; R.sup.4 represents hydrogen, hydroxy, lower alkyl, substituted or unsubstituted aralkyl, lower alkoxy, substituted or unsubstituted aralkyloxy, or halogen; and X represents substituted or unsubstituted indolyl; or pharmaceutically acceptable salts thereof.Type: GrantFiled: November 26, 1996Date of Patent: September 14, 1999Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Shun-Ichi Ikeda, Uichiro Kimura, Tadashi Ashizawa, Katsushige Gomi, Hiromitsu Saito, Masaji Kasai, Junji Kanazawa, Kimihito Sasaki, Etsuko Nukui, Masami Okabe, Soichiro Sato
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Patent number: 5733924Abstract: DC107 derivatives represented by the formula (I): ##STR1## or pharmacologically acceptable slats thereof, ?wherein R.sup.1 is hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR.sup.4 or the like; R.sup.2 represents hydrogen or COR.sup.5 ; R.sup.3 represents lower alkyl, lower alkenyl, aralkyl which may be substituted with substituted or unsubstituted aryl, lower alkoxyalkyl, aralkyloxyalkyl, substituted or unsubstituted aryloxyalkyl, lower alkoxycarbonylalkyl, lower alkanoyloxyalkyl, alicyclic alkanoyloxyalkyl or the like, or bonds to Y to represent a single bond; Y bonds to R.sup.3 to represent a single bond, or bonds to Z to represent a single bond; Z represents hydrogen or bonds to Y to represent a single bond; W represents oxygen or NR.sup.6, with the proviso that the compound wherein R.sup.1, R.sup.2 and Z each represents hydrogen, R.sup.3 bonds to Y to represent a single bond, and W represents oxygen (DC107) is excluded.Type: GrantFiled: April 17, 1997Date of Patent: March 31, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yutaka Kanda, Yutaka Saitoh, Hiromitsu Saito, Tadashi Ashizawa, Kazuyo Sugiyama, Katsushige Gomi, Shingo Kakita, Yuichi Takahashi, Chikara Murakata
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Patent number: 5717110Abstract: This invention relates to UCH15 compounds of the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a hydroxyl group.Type: GrantFiled: May 12, 1997Date of Patent: February 10, 1998Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Tamio Mizukami, Akira Asai, Yoshinori Yamashita, Hirofumi Nakano, Shingo Kakita, Youichi Uosaki, Keiko Ochiai, Tadashi Ashizawa, Akira Mihara
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Patent number: 5656736Abstract: The present invention relates to the compound UCH9 represented by the following formula: ##STR1## which has antibacterial and anti-tumor activity, and pharmaceutically acceptable salts thereof.Type: GrantFiled: April 21, 1995Date of Patent: August 12, 1997Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hirofumi Nakano, Harumi Ogawa, Yoshinori Yamashita, Ritsuko Katahira, Shigeru Chiba, Toshiaki Iwasaki, Tadashi Ashizawa
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Patent number: 5334611Abstract: Novel mitomycin derivatives represented by the formula (I) are obtained by introducing a substituent at the 6-position. The mitomycin derivatives of the present invention have an antitumor activity.Type: GrantFiled: August 3, 1993Date of Patent: August 2, 1994Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hitoshi Arai, Yutaka Kanda, Motomichi Kono, Masaji Kasai, Tadashi Ashizawa, Katsushige Gomi
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Patent number: 5256685Abstract: Novel mitomycin derivatives represented by the formula (I) are obtained by introducing a substituent at the 6-position. The mitomycin derivatives of the present invention have an antitumor activity.Type: GrantFiled: March 26, 1992Date of Patent: October 26, 1993Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hitoshi Arai, Yutaka Kanda, Motomichi Kono, Masaji Kasai, Tadashi Ashizawa, Katsushige Gomi
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Patent number: 5220026Abstract: Disclosed is pyrazoloacridone derivatives represented by formula (I): ##STR1## wherein: each of R.sup.1a, R.sup.1b, R.sup.1c and R.sup.1d independently represents hydrogen, lower alkyl, --(CH.sub.2).sub.p --Xwherein p represents an integer of 1 to 6, and X represents hydroxy, lower alkoxy or --NR.sup.2a R.sup.2bwherein each of R.sup.2a and R.sup.2b independently represents hydrogen, lower alkyl, or --(CH.sub.2).sub.m --Ywherein m represents an integer of 1 to 6, and Y represents hydroxy, lower alkoxy or --NR.sup.3a R.sup.3bwherein each of R.sup.3a and R.sup.3b independently represents hydrogen or lower alkylor --CH[(CH.sub.2).sub.n OH].sub.2wherein n represents an integer of 1 to 5; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 18, 1991Date of Patent: June 15, 1993Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Yukiteru Mimura, Yasushi Shida, Masaji Kasai, Tadashi Ashizawa, Katsushige Gomi
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Patent number: 5218126Abstract: Disclosed are mitomycin derivatives of formula (I): ##STR1## where W represents halogen; X represents methoxy, amino or ethylenimino; Y represents hydrogen or methyl; Z represents hydrogen or methyl; and one of R.sup.1 and R.sup.2 represents carbamoyloxymethyl, and the other represents hydrogen. The derivatives are usable as an antitumor and antibacterial agent.Type: GrantFiled: September 5, 1991Date of Patent: June 8, 1993Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hitoshi Arai, Masaji Kasai, Katsushige Gomi, Tadashi Ashizawa
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Patent number: 5180825Abstract: Disclosed in a mitomycin derivative represented by the formula (I): ##STR1## wherein W is a heterocyclic group.Type: GrantFiled: November 13, 1991Date of Patent: January 19, 1993Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Hitoshi Arai, Motomichi Kono, Masaji Kasai, Katsushige Gomi, Tadashi Ashizawa
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Patent number: 5138059Abstract: Novel DC-89 compounds represented by the general formula: ##STR1## wherein X represents a single bond or --CH.sub.2 --; and when X represents a single bond, Y represents --CH.sub.2 Br or --CH.sub.2 Cl and when X represents --CH.sub.2 --, Y represents Br, are obtained by the present invention. The compounds have antibacterial and anti-tumor activity.Type: GrantFiled: July 17, 1989Date of Patent: August 11, 1992Assignee: Kyowa Hakko Kogyo Co., Ltd.Inventors: Keiichi Takahashi, Michio Ichimura, Shigeo Katsumata, Tatsuhiro Ogawa, Makoto Morimoto, Tadashi Ashizawa, Masaji Kasai, Kenichi Muroi, Hiromitsu Saito, Hiroshi Sano, Toru Yasuzawa