Patents by Inventor Tadashi Hase
Tadashi Hase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20080249171Abstract: Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to accumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of ?-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of ?-oxidation and activating lipid catabolism.Type: ApplicationFiled: May 22, 2008Publication date: October 9, 2008Applicant: KAO CORPORATIONInventors: Tadashi Hase, Takatoshi Murase, Hiroyuki Watanabe, Hidehiko Kondo
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Publication number: 20070287691Abstract: Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to accumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of ?-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of ?-oxidation and activating lipid catabolism.Type: ApplicationFiled: July 23, 2007Publication date: December 13, 2007Applicant: KAO CORPORATIONInventors: Tadashi HASE, Takatoshi Murase, Hiroyuki Watanabe, Hidehiko Kondo
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Patent number: 7182971Abstract: Disclosed herein is an oil composition comprising the following components (A) and (B):(A) 15 to 70% by weight of diglycerides in which less than 15% by weight of the constitutive fatty acids are (3 type unsaturated fatty acids; and (B) 30 to 85% by weight of a triglyceride in which at least 15% by weight of the constitutive fatty acids are (3 type unsaturated fatty acids. The oil composition is good in flavor, hard to be colored, excellent in hydrolytic stability and resistance to oxidation, good in emulsion stability and excellent in intake balance among fatty acids even under severe conditions that heating is performed at a high temperature for a long period of time, can be widely developed to medicinal preparations and foods and moreover exhibit an excellent inhibitory effect on accumulation of body fat by ingestion of a small amount of diglycerides.Type: GrantFiled: September 12, 2002Date of Patent: February 27, 2007Assignee: Kao CorporationInventors: Hideto Takase, Shin Koike, Hideaki Sakai, Tsutomu Nishide, Tadashi Hase, Takatoshi Murase
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Patent number: 7090886Abstract: Abstract Provided is an oil/fat composition comprising 60 to 100 wt. % of a diglyceride wherein the diglyceride has, as the fatty acid constituent thereof, 15 to 90 wt. % of an ? 3-unsaturated fatty acid having less than 20 carbon atoms and a cis ? 3-unsaturated fatty acid/(cis ? 6-unsaturated fatty acid+saturated fatty acid+trans unsaturated fatty acid) at a weight ratio of 1 to 6. The composition is excellent in visceral fat burning property, body fat burning property and stability against autoxidation.Type: GrantFiled: August 7, 2001Date of Patent: August 15, 2006Assignee: Kao CorporationInventors: Shin Koike, Takeshi Yasumasu, Tadashi Hase, Takatoshi Murase, Yoshihisa Katsuragi, Akira Takei
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Patent number: 7056949Abstract: An oil/fat composition comprising 5 to 99.9 wt. % of a monoglyccride having, as fatty acid constituents thereof, 15 to 90 wt % of an ? 3-unsaturated fatty acid having less than 20 carbon atoms, 1 to 80 wt. % of an ? 9-unsaturated fatty acid and 2 to 50 wt. % of an ? 9-unsaturated fatty acid; and 0.1 to 49.9 wt. % of a diglyceride, wherein a weight ratio of the diglyceride to the monoglyceride is less than 1 and the content of a polyunsaturated fatty acid having at least 4 carbon-to-carbon double bonds is 20% or less in all the fatty acid constituents. The oil/fat composition according to the present invention has excellent processing properties, good taste and excellent lowering action against glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels in blood. It is useful not only for pharmaceuticals but also for preventive or remedial foods of feeds effective for hepatic function disturbances or obesity.Type: GrantFiled: August 7, 2001Date of Patent: June 6, 2006Assignee: Kao CorporationInventors: Shin Koike, Takeshi Yasumasu, Tadashi Hase, Takatoshi Murase
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Patent number: 7008661Abstract: Provided is an oil/fat composition comprising 10.1 to 94.9 wt. % of a triglyceride, 0.1 to 30 wt. % of a monoglyceride and 5 to 59.9 wt. % of a diglyceride which has, as a fatty acid constituent thereof, 15 to 90 wt. % of an ?3-unsaturated fatty acid having less than 20 carbon atoms. The oil/fat composition of the present invention has excellent heat stability, has body-fat-accumulation resisting action, visceral-fat-accumulation resisting action, blood-sugar-level lowering action, insulin resistance improving action and leptin lowering action and is useful for, as well as pharmaceuticals, preventive or remedial food for diabetes or obesity, and feed.Type: GrantFiled: August 7, 2001Date of Patent: March 7, 2006Assignee: Kao CorporationInventors: Shin Koike, Takeshi Yasumasu, Tadashi Hase, Takatoshi Murase, Yoshihisa Katsuragi, Akira Takei
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Publication number: 20050256190Abstract: Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to ?-cumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of ?-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of ?-oxidation and activating lipid catabolism.Type: ApplicationFiled: July 21, 2005Publication date: November 17, 2005Applicant: KAO CORPORATIONInventors: Tadashi Hase, Takatoshi Murase, Hiroyuki Watanabe, Hidehiko Kondo
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Patent number: 6956058Abstract: Methods are disclosed for improving insulin resistance in a diabetic comprising administering a diacylglycerol.Type: GrantFiled: September 11, 2002Date of Patent: October 18, 2005Assignee: Kao CorporationInventors: Tadashi Hase, Takatoshi Murase, Hiroyuki Watanabe, Hidehiko Kondo
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Publication number: 20050148666Abstract: Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to accumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of ?-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of ?-oxidation and activating lipid catabolism.Type: ApplicationFiled: February 10, 2005Publication date: July 7, 2005Applicant: KAO CORPORATIONInventors: Tadashi Hase, Takatoshi Murase, Hiroyuki Watanabe, Hidehiko Kondo
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Publication number: 20050137258Abstract: Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to accumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of ?-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of ?-oxidation and activating lipid catabolism.Type: ApplicationFiled: February 10, 2005Publication date: June 23, 2005Applicant: KAO CORPORATIONInventors: Tadashi Hase, Takatoshi Murase, Hiroyuki Watanabe, Hidehiko Kondo
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Patent number: 6844021Abstract: The oil or fat composition of the invention contains a monoacylglycerol and/or a diacylglycerol in a total amount of 5-100 wt. % and which exhibits an index of stability against oxidation (induction time as measured through a Rancimat test conducted at 100° C.) of 7 or higher, wherein the monoacylglycerol and/or the diacylglycerol contain, as fatty acid constituents, ?3 unsaturated fatty acids in amounts of 15-90 wt. %. Through ingestion thereof in a small amount without drastically changing the person's lifestyle, the highly harmless oil/fat composition of the present invention provides effects for reducing and preventing accumulation of body fat, for reducing and preventing accumulation of visceral fat, and for prevention and treatment of obesity; and exerts an excellent prevention and treatment effect on life-style related diseases through long-term ingestion. Thus, the composition of the present invention is useful for foods, pharmaceuticals and pet food or feed.Type: GrantFiled: April 26, 2002Date of Patent: January 18, 2005Assignee: Kao CorporationInventors: Shin Koike, Takatoshi Murase, Tadashi Hase
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Publication number: 20040265466Abstract: Disclosed herein is an oil composition comprising the following components (A) and (B):(A) 15 to 70% by weight of diglycerides in which less than 15% by weight of the constitutive fatty acids are (3 type unsaturated fatty acids; and (B) 30 to 85% by weight of a triglyceride in which at least 15% by weight of the constitutive fatty acids are (3 type unsaturated fatty acids. The oil composition is good in flavor, hard to be colored, excellent in hydrolytic stability and resistance to oxidation, good in emulsion stability and excellent in intake balance among fatty acids even under severe conditions that heating is performed at a high temperature for a long period of time, can be widely developed to medicinal preparations and foods and moreover exhibit an excellent inhibitory effect on accumulation of body fat by ingestion of a small amount of diglycerides.Type: ApplicationFiled: August 18, 2004Publication date: December 30, 2004Inventors: Hideto Takase, Shin Koike, Hideaki Sakai, Tsutomu Nishide, Tadashi Hase, Takatoshi Murase
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Publication number: 20040062847Abstract: An oil/fat composition comprising 5 to 99.9 wt. % of a monoglyccride having, as fatty acid constituents thereof, 15 to 90 wt % of an &ohgr; 3-unsaturated fatty acid having less than 20 carbon atoms, 1 to 80 wt. % of an &ohgr; 9-unsaturated fatty acid and 2 to 50 wt. % of an &ohgr; 9-unsaturated fatty acid; and 0.1 to 49.9 wt. % of a diglyceride, wherein a weight ratio of the diglyceride to the monoglyceride is less than 1 and the content of a polyunsaturated fatty acid having at least 4 carbon-to-carbon double bonds is 20% or less in all the fatty acid constituents. The oil/fat composition according to the present invention has excellent processing properties, good taste and excellent lowering action against glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels in blood. It is useful not only for pharmaceuticals but also for preventive or remedial foods of feeds effective for hepatic function disturbances or obesity.Type: ApplicationFiled: February 6, 2003Publication date: April 1, 2004Inventors: Shin Koike, Takeshi Yasumasu, Tadashi Hase, Takatoshi Murase
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Publication number: 20040052920Abstract: Abstract Provided is an oil/fat composition comprising 60 to 100 wt. % of a diglyceride wherein the diglyceride has, as the fatty acid constituent thereof, 15 to 90 wt. % of an &ohgr; 3-unsaturated fatty acid having less than 20 carbon atoms and a cis &ohgr; 3-unsaturated fatty acid/(cis &ohgr; 6-unsaturated fatty acid+saturated fatty acid+trans unsaturated fatty acid) at a weight ratio of 1 to 6. The composition is excellent in visceral fat burning property, body fat burning property and stability against autoxidation.Type: ApplicationFiled: February 6, 2003Publication date: March 18, 2004Inventors: Shin Koike, Takeshi Yasumasu, Tadashi Hase, Takatoshi Murase, Yoshihisa Katsuragi, Akira Takei
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Publication number: 20030198727Abstract: Provided is an oil/fat composition comprising 10.1 to 94.9 wt. % of a triglyceride, 0.1 to 30 wt. % of a monoglyceride and 5 to 59.9 wt. % of a diglyceride which has, as a fatty acid constituent thereof, 15 to 90 wt. % of an &ohgr;3-unsaturated fatty acid having less than 20 carbon atoms. The oil/fat composition of the present invention has excellent heat stability, has body-fat-accumulation resisting action, visceral-fat-accumulation resisting action, blood-sugar-level lowering action, insulin resistance improving action and leptin lowering action and is useful for, as well as pharmaceuticals, preventive or remedial food for diabetes or obesity, and feed.Type: ApplicationFiled: February 10, 2003Publication date: October 23, 2003Inventors: Shin Koike, Takeshi Yasumasu, Tadashi Hase, Takatoshi Murase, Yoshihisa Katsuragi, Akira Takei
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Publication number: 20030158257Abstract: Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diacylglycerol. Also disclosed are methods for improving various symptoms in diabetes, which have ingesting a diacylglycerol. Ingestion of the diacylglycerol leads to accumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of &bgr;-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triacylglycerols. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of &bgr;-oxidation and activating lipid catabolism.Type: ApplicationFiled: September 11, 2002Publication date: August 21, 2003Applicant: KAO CORPORATIONInventors: Tadashi Hase, Takatoshi Murase, Hiroyuki Watanabe, Hidehiko Kondo
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Publication number: 20030096866Abstract: Disclosed are a method for activating lipid metabolism in the small intestine epithelium and also a method for promoting accumulation of fatty acids into the small intestine epithelium, each of which features administering an effective amount of a diglyceride. Ingestion of the diglyceride leads to accumulation of the fatty acids in the small intestine. The fatty acids so accumulated promote induction of &bgr;-oxidation, thereby not only activating lipid catabolism but also making it difficult to allow lipids to accumulate as triglycerides. This series of actions eventually results in development of lowering action for blood remnant-like lipoprotein level and also lowering action for blood leptin level, and hence, lipid metabolism is improved. Further, energy consumption is enhanced by promoting the induction of &bgr;-oxidation and activating lipid catabolism.Type: ApplicationFiled: April 25, 2002Publication date: May 22, 2003Applicant: Kao CorporationInventors: Tadashi Hase, Takatoshi Murase, Hiroyuki Watanabe, Hidehiko Kondo
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Publication number: 20030054082Abstract: The oil or fat composition of the invention contains a monoacylglycerol and/or a diacylglycerol in a total amount of 5-100 wt. % and which exhibits an index of stability against oxidation (induction time as measured through a Rancimat test conducted at 100° C.) of 7 or higher, wherein the monoacylglycerol and/or the diacylglycerol contain, as fatty acid constituents, &ohgr;3 unsaturated fatty acids in amounts of 15-90 wt. %. Through ingestion thereof in a small amount without drastically changing the person's lifestyle, the highly harmless oil/fat composition of the present invention provides effects for reducing and preventing accumulation of body fat, for reducing and preventing accumulation of visceral fat, and for prevention and treatment of obesity; and exerts an excellent prevention and treatment effect on life-style related diseases through long-term ingestion. Thus, the composition of the present invention is useful for foods, pharmaceuticals and pet food or feed.Type: ApplicationFiled: April 26, 2002Publication date: March 20, 2003Applicant: Kao CorporationInventors: Shin Koike, Takatoshi Murase, Tadashi Hase
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Patent number: 5753707Abstract: An amide derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents a C.sub.1-40 hydrocarbon; R.sup.2 represents a C.sub.1-6 alkylene; R.sup.3 represents H, OH or alkoxyl; R.sup.4 represents a C.sub.1-39 hydrocarbon; R.sup.5 represents ##STR2## with the proviso that when R.sup.5 represents ##STR3## R.sup.3 does not represent OH; and a composition of the amide derivative for topical application to human skin. The composition improves the barrier function of the stratum corneum, providing improvement and prevention of dermatitis, skin roughness, or similar disorders.Type: GrantFiled: September 6, 1996Date of Patent: May 19, 1998Assignee: Kao CorporationInventors: Masahide Hoshino, Hiroshi Kusuoku, Tadashi Hase, Atsuko Otsuka, Ichiro Tokimitsu, Akira Yamamuro, Yoshiya Sugai, Koji Yoshino, Youichi Arai, Shinichi Meguro
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Patent number: 5126434Abstract: The present invention relates to a monoclonal antibody which specifically binds to a peptide having amino acid sequence (I) described below or having in part at least continuous 4 amino acid sequences of the amino acid sequence (I), and also to a process for producing a monoclonal antibody capable of specifically binding to the peptide represented by the following amino acid sequence:H-Y-Leu-Gly-Arg-X-Asp-Gly-Ser-Glu-OH (I)wherein X represents Glu or Gln and Y represents Trp or Arg.Type: GrantFiled: August 2, 1990Date of Patent: June 30, 1992Assignee: Kao CorporationInventors: Toshiaki Osawa, Tadashi Hase, Naonobu Yoshizuka