Abstract: Described is a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH (SEQ ID NO: 2) wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.

Abstract: The present invention relates to a labeling technique which can facilitate the metabolism in the liver after administration to patients without the reduction in the antibody function, thereby reducing accumulation of radionuclides in an organ such as the liver, and provides a modified antibody containing an IgG antibody and an IgG-binding peptide bound to the IgG antibody. The IgG-binding peptide has an amino acid sequence consisting of 13 to 17 amino acid residues, such as GPDCAYH(Xaa1)GELVWCTFH wherein Xaa1 represents a lysine residue, a cysteine residue, an aspartic acid residue, a glutamic acid residue, 2-aminosuberic acid, or diaminopropionic acid, and a compound represented by the following formula (II-1) is linked at a position of the lysine residue via a modification linker to the N terminus of the IgG-binding peptide.

Abstract: A rigid endoscope for prostate biopsy includes: an insertion portion including a distal end portion including an ultrasound transmission and reception portion, and a bent portion bent at a predetermined curvature; a treatment instrument insertion channel that passes through inside the bent portion and includes a first opening portion provided on a distal end side and a second opening portion provided on a proximal end side; a shaft-shaped portion installed to extend in a proximal end direction of the bent portion along a straight line passing through an inflection portion provided between the distal end portion and the bent portion; and a grasping portion that includes the shaft-shaped portion.

Abstract: A rigid endoscope for prostate biopsy includes: an insertion portion including a distal end portion including an ultrasound transmission and reception portion, and a bent portion bent at a predetermined curvature; a treatment instrument insertion channel that passes through inside the bent portion and includes a first opening portion provided on a distal end side and a second opening portion provided on a proximal end side; a shaft-shaped portion installed to extend in a proximal end direction of the bent portion along a straight line passing through an inflection portion provided between the distal end portion and the bent portion; and a grasping portion that includes the shaft-shaped portion.

Abstract: A receptacle type optical apparatus is provided that prevents occurrence of misalignment in coupling optical waveguides. The receptacle type optical apparatus includes an optical device module having a light-emitting device and a light-receiving device, and an enclosure that stores the optical device module, the receptacle type optical apparatus allowing a part of an optical connector to be inserted inside the enclosure and establishing connection with the optical connector. An inner spatial area is formed in the enclosure that allows the part of the optical connector and the optical device module to be swingable with respect to a predetermined position in the optical device module. Furthermore, a support member is provided to swingably support the part of the optical connector and the optical device module integrally at the predetermined position.

Abstract: An optical transmitter in which a microstripline is formed by a signal wiring pattern and a GND conductor pattern on a circuit board (including a flexible board), and a signal lead of a light emitting element module is mounted in a signal lead mounting hole connected with said signal wiring pattern so as to be connected with said signal wiring pattern, wherein a pattern adapted to add capacitance between a stem of said light emitting element module and said signal wiring pattern is provided on said signal wiring pattern on said circuit board, and wherein the pattern adapted to add capacitance has a size corresponding to ±50% of a capacitance C?L/Zo2, where Zo is signal line impedance, and L is the signal lead inductance.

Abstract: An ultrasonic endoscope has an ultrasonic probe, an observation optical system and a channel for inserting a medical instrument. A transurethral diagnostic method using the ultrasonic endoscope comprising step of inserting an insertion portion of the ultrasonic endoscope toward a target diagnostic portion through a urethral, step of starting transmission of an ultrasonic wave from the ultrasonic probe which has reached the vicinity of the target diagnostic portion and displaying at least a B-mode image of the target diagnostic portion on a screen, step of identifying a puncture position from the B-mode image displayed on the screen, and step of puncturing the puncture position identified on the screen with a medical instrument through the channel for inserting the medical instrument.

Abstract: The present invention provides an optical transmission module having a laser diode that generates laser beams and a differential type current switch provided with a first switch and a second switch in order to supply a modulating current to the laser diode. A terminal of the laser diode and the first switch are connected in series through a first transmission line and a first capacitor, the other terminal of the laser diode and the second switch are connected in series through a second transmission line and a second capacitor. The current driven by the second switch is terminated by a resistor connected to the first switch and the current driven by the first switch is terminated by a resistor connected to the second switch. Thus, the laser diode is modulated bidirectionally.

Abstract: An optical transmitter in which a microstripline is formed by a signal wiring pattern and a GND conductor pattern on a circuit board (including a flexible board), and a signal lead of a light emitting element module is mounted in a signal lead mounting hole connected with said signal wiring pattern so as to be connected with said signal wiring pattern, wherein a pattern adapted to add capacitance between a stem of said light emitting element module and said signal wiring pattern is provided on said signal wiring pattern on said circuit board, and wherein the pattern adapted to add capacitance has a size corresponding to ±50% of a capacitance C?L/Zo2, where Zo is signal line impedance, and L is the signal lead inductance.

Abstract: An optical transmitter receiver module and an apparatus incorporating the same module are provided, which realizes the reduction of power consumption and the enlargement of the operating temperature range.

Abstract: The present invention provides an optical transmission module having a laser diode that generates laser beams and a differential type current switch provided with a first switch and a second switch in order to supply a modulating current to the laser diode. A terminal of the laser diode and the first switch are connected in series through a first transmission line and a first capacitor, the other terminal of the laser diode and the second switch are connected in series through a second transmission line and a second capacitor. The current driven by the second switch is terminated by a resistor connected to the first switch and the current driven by the first switch is terminated by a resistor connected to the second switch. Thus, the laser diode is modulated bidirectionally.

Abstract: A temperature compensating circuit includes a first circuit network 1 between an inverting input terminal of an operational amplifier 13 and an output terminal of the operational amplifier 13, and a second circuit network 2 between the inverting input terminal of the operational amplifier 13 and a reference potential. At least one of the first circuit network and the second circuit network is made of an arrangement containing a plurality of series-connected thermistor/resistor pairs in which the thermistors are connected parallel to the resistors, and the temperature compensating circuit compensates a temperature-dependent signal which is inputted into a positive phase input terminal of the operational amplifier 13, and outputs the temperature-compensated signal.

Abstract: A temperature compensating circuit includes a first circuit network 1 between an inverting input terminal of an operational amplifier 13 and an output terminal of the operational amplifier 13, and a second circuit network 2 between the inverting input terminal of the operational amplifier 13 and a reference potential. At least one of the first circuit network and the second circuit network is made of an arrangement containing a plurality of series-connected thermistor/resistor pairs in which the thermistors are connected parallel to the resistors, and the temperature compensating circuit compensates a temperature-dependent signal which is inputted into a positive phase input terminal of the operational amplifier 13, and outputs the temperature-compensated signal.

Abstract: A temperature compensating circuit includes a first circuit network 1 between an inverting input terminal of an operational amplifier 13 and an output terminal of the operational amplifier 13, and a second circuit network 2 between the inverting input terminal of the operational amplifier 13 and a reference potential. At least one of the first circuit network and the second circuit network is made of an arrangement containing a plurality of series-connected thermistor/resistor pairs in which the thermistors are connected parallel to the resistors, and the temperature compensating circuit compensates a temperature-dependent signal which is inputted into a positive phase input terminal of the operational amplifier 13, and outputs the temperature-compensated signal.

Abstract: An optical transmitter receiver module and an apparatus incorporating the same module are provided, which realizes the reduction of power consumption and the enlargement of the operating temperature range.

Abstract: A temperature compensating circuit includes a first circuit network 1 between an inverting input terminal of an operational amplifier 13 and an output terminal of the operational amplifier 13, and a second circuit network 2 between the inverting input terminal of the operational amplifier 13 and a reference potential. At least one of the first circuit network and the second circuit network is made of an arrangement containing a plurality of series-connected thermistor/resistor pairs in which the thermistors are connected parallel to the resistors, and the temperature compensating circuit compensates a temperature-dependent signal which is inputted into a positive phase input terminal of the operational amplifier 13, and outputs the temperature-compensated signal.

Abstract: Disclosed is a device for supporting a training for prevention against incontinence of urine, comprising: an input unit; an indicator unit; a decision unit; and a display unit. The input unit enters the fact that a user is performing the training for prevention against incontinence of urine, and the indicator unit produces a timing indication for the training for prevention against incontinence of urine. Furthermore, the decision unit determines that the training for prevention against incontinence of urine is correctly performed on the basis of the input signal sent from the input unit, and the display unit performs displaying according to the result of decision made by the decision unit.

Abstract: An optical transmitter includes a plurality of optical wavelength stability control apparatuses, each of which is capable of compensating for a wavelength drift by varying a laser diode drive current. Each of the optical wavelength stability control apparatuses detects a laser diode drive current, which is controlled by an auto power control circuit, by using a laser diode drive current detector. The laser diode drive current is normalized by a laser diode drive current increase/decrease normalization unit. A laser diode temperature control target value is generated at a compensated reference voltage generator, in response to the normalized laser diode drive current, to control a current value applied to a thermoelectric cooler so that an output value of a temperature monitor circuit approaches a predetermined laser diode temperature control target value.

Abstract: A plurality of arms are successively connected to a fixed arm so that the free end of the connected arms is movable three-dimensionally, a direct-access endoscope is attached to the three-dimensionally movable free end of the arms, and angle sensors are provided in the individual arm joints. Changes in angles between the individual arms due to the movement of the front end of the direct-access endoscope are sensed by the angle sensors, and the size and position of the object are numerically determined according to the changes.