Abstract: This invention relates to cysteine derivatives of the formula[I] and salts thereof. ##STR1## The compounds of this invention are useful for immunomodulator and treatment of liver disorder.

Abstract: A compound of the formula [II] or pharmaceutically acceptable salt thereof, ##STR1## wherein R.sup.1 is hydrogen or fluorine;R.sup.2 is hydrogen or fluorine;R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halogen or lower alkylenedioxy;A is straight or branched lower alkylene having 1 to 6 carbon atoms; and n is 0 or 1,provided that at least one of R.sup.1 or R.sup.2 is fluorine. Such compound is useful for treatment of disorders of the cerebro-neural transmission system.

Abstract: This invention relates to cyclic sulfur-containing compounds of the formula [I] and salts thereof which are useful for immunomodulator and treatment of liver diseases.

Abstract: A method for treatment of disorders of the cerebro-neural transmission system which comprises administering a compound of the formula (I) or a pharmaceutically acceptable salt thereof in a therapeutically effective amount, either alone or in admixture with one or more pharmaceutically acceptable excipients, ##STR1## wherein Ar or Ar' is unsubstituted or substituted phenyl or pyridyl; R is hydrogen, lower alkyl, lower alkoxy, halogen or lower alkylenedioxy; A is C.sub.1 -C.sub.6 alkylene; and n is 0 or 1. A compound of the formula (II) or a pharmaceutically acceptable salt thereof, ##STR2## wherein R.sup.1 is hydrogen or fluorine; R.sup.2 is hydrogen or fluorine; R.sup.3 is hydrogen, lower alkyl, lower alkoxy, halogen or lower alkylenedioxy; A is lower C.sub.1 -C.sub.6 alkylene, and n is 0 or 1, provided that at least one of R.sup.1 or R.sup.2 is fluorine.

Abstract: A pharmaceutical composition for treatment of an autoimmune disease, which comprises (i) a pharmaceutical carrier and (ii) a compound of the formula (I) or pharmaceutically acceptable salts thereof in an amount effective for treatment of an autoimmune disease, ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is lower alkyl; and R.sup.3 is hydrogen or lower alkyl.

Abstract: Cyclic sulfur-containing compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is hydrogen or lower alkyl,R.sup.3 is hydrogen or lower alkyl,X is S--S,m is 0 or 1 andn is 1 or 2, with the proviso that when m is 0,n is 2, and pharmaceutically acceptable salts thereof.Such compounds are useful for treating liver disorders and autoimmune diseases.

Abstract: This invention relates to low irritative ophthalmics containing the compound of the formula or salts thereof which are useful for treatment of anti-allergic eye diseases such as allergic conjunctivitis ##STR1##

Abstract: This invention relates to novel benzothizine derivatives of the formula [I], processes for preparing them and therapeutic agents for circulatory diseases containing them as an active ingredient, ##STR1## wherein R.sup.1 is one or more groups selected from those consisting of hydrogen, lower alkyl, halogen, nitro, hydroxy, lower alkoxy, lower alkanoyloxy, amino, lower alkylamino and lower alkoxycarbonyloxy;R.sup.2 is hydrogen, lower alkyl or (C.sub.3 -C.sub.6)cycloalkyl;R.sup.3 is one or more groups selected from those consisting of hydrogen, lower alkyl, hydroxy, lower alkoxy, halogen, nitro, lower alkylenedioxy, lower alkanoyloxy, lower alkanoyl, amino, lower alkylamino, lower alkanoylamino and lower alkoxycarbonyloxy or ##STR2## R.sup.4 is hydrogen or lower alkyl.

Abstract: This invention relates to benzothiazine derivatives represented by the formula [I] and salts thereof, which are useful for treatment of cardiovascular diseases.

Abstract: The invention relates to benzothiazoline derivatives of the formula [I] and salts thereof, which are useful for (i) treating cardiovascular diseases, and (ii) as the active ingredient of pharmaceutical compositions. Formula [I] follows: ##STR1## wherein R.sup.1 is lower alkanoyl;R.sup.2 is one or more group(s) selected from hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, nitro, halogenolower alkyl and sulfamoyl;R.sup.3 is --COR.sup.8 ;R.sup.8 is hydroxy, lower alkoxy, ##STR2## Z is straight or branched alkylene containing 1 to 6 carbon atoms; m is 0 or 1; n is 0 or 1; and p is 4 or 5.

Abstract: The invention relates to benzothiazoline derivatives of the formula [I] and salts thereof, which are useful for (i) treating cardiovascular diseases, and (ii) as the active ingredient of pharmaceutical compositions. Formula [I] follows: ##STR1## wherein R.sup.1 is lower alkanoyl;R.sup.2 is one or more group(s) selected from hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, nitro, halogenolower alkyl and sulfamoyl;R.sup.3 is ##STR2## R.sup.4 and R.sup.5 each is hydrogen, lower alkyl, cyclohexyl or substituted lower alkyl;Z is straight or branched alkylene containing 1 to 6 carbon atoms;m is 0 or 1; n is 0 or 1; and p is 4 or 5.

Abstract: Aletheine derivatives of the general formula ##STR1## which are useful for treatment of liver damage.

Abstract: This invention relates to novel benzothiazoline derivatives of the formula [I] and salts thereof, ##STR1## wherein R.sup.1 is formyl or lower alkanoyl;R.sup.2 is hydrogen, lower alkyl, lower alkoxy or nitro;R.sup.3 is hydrogen, lower alkyl, lower alkoxy or halogen;A is lower alkylene;B is --CO--(CH.sub.2).sub.m -- or --CH(OH)--;m is 0 or 1; andwhen m is 0, R.sup.3 is not hydrogen.The compounds of this invention are useful for treatment of cardiovascular diseases.

Abstract: Pharmaceutically active compounds and pharmaceutically acceptable salts thereof having the following formulae ##STR1## wherein A is a straight or branched chain alkylene group containing 1 to 3 carbon atoms; and R.sup.7 and R.sup.8 is each a lower alkyl group. These compounds are useful as the active component of pharmacological preparations.

Abstract: Thiazolidine and pyrrolidine compounds which have the general formula ##STR1## and salts thereof for preventing or relieving diabetic complications and for reducing blood pressure, the processes for their preparation, and the compositions comprising them and pharmaceutically acceptable excipient(s).

Abstract: Novel S-substituted mercapto-lower alkanoyl-4-thiazolidinecarboxylic acids, -2-pyrrolidinecarboxylic acids and their esters represented by the general formula ##STR1## wherein Q is methylene or sulfur;Z is straight or branched alkylene with 1 to 3 carbon atoms, their process for manufacturing, the antihypertensive composition comprising these compounds and the method for reducing blood pressure.

Abstract: Novel S-substituted mercapto-lower alkanoyl-4-thiazolidinecarboxylic acids, -2-pyrrolidinecarboxylic acids and their esters represented by the general formula ##STR1## wherein Q is methylene or sulfur;Z is straight or branched alkylene with 1 to 3 carbon atoms,their process for manufacturing, the antihypertensive composition comprising these compounds and the method for reducing blood pressure.

Abstract: This invention relates to inclusion compounds of cyclodextrin with the compounds of the general formula [I] and salts thereof, which show pharmacological effects (for example antihypertensive effect), ##STR1## wherein A is straight or branched lower alkylene;R.sup.1 is hydrogen or lower alkyl;R.sup.2 is hydrogen, lower alkyl, phenyl, phenyl-lower alkyl, hydroxyphenyl-lower alkyl, hydroxy-lower alkyl, amino-lower alkyl, guanidino-lower alkyl, imidazolyl-lower alkyl, indolyl-lower alkyl, mercapto-lower alkyl or lower alkylthio-lower alkyl;R.sup.1 or R.sup.2 may join to complete pyrrolidine ring or thiazolidine ring, and each ring may be substituted by phenyl or pyridyl, and phenyl may be resubstituted by hydroxy, lower alkoxy, halogen, nitro or sulfamoyl;R.sup.3 is hydrogen or ##STR2## said lower alkyl and lower alkoxy having 1 to 6 carbon atoms.

Abstract: This invention relates to benzothiazoline derivatives of the formula [I] and salts thereof, which are useful for (i) treating cardiovascular diseases, and (ii) as the active ingredient of pharmaceutical compositions. Formula [I] follows: ##STR1## wherein R.sup.1 is lower alkanoyl;R.sup.2 is one or more group(s) selected from hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen, nitro, halogeno-lower alkyl and sulfamoyl;R.sup.3 is ##STR2## R.sup.6 is hydrogen, alkyl, substituted alkyl, alkanoyl, substituted alkanoyl, alkenoyl, substituted alkenoyl or furylcarbonyl;R.sup.7 is hydrogen, hydroxy, phenyl-lower alkyl or banzoyl;Z is strainght or branched alkylene containing 1 to 6 carbon atoms;m is 0 or 1; n is 0 or 1; and p is 5.

Abstract: This invention relates to the compound of the general formula [I], process for preparing the compound and antihypertensive agent containing the compound as a main ingredient. ##STR1## wherein R.sup.1 is hydrogen, hydroxy, lower alkyl or lower alkoxy;R.sup.2 is hydrogen, benzoyl or ##STR2## R.sup.3 is hydroxy, lower alkoxy, --NHOH or ##STR3## R.sup.4 is ##STR4## R.sup.5 is hydrogen or halogen; R.sup.6 and R.sup.7 each is hydrogen or lower alkyl;Z is straight or branched alkylene containing 1 to 3 carbon atoms;when R.sup.3 is hydroxy or lower alkoxy, R.sup.2 is ##STR5## and salts thereof, said lower alkyl and lower alkoxy groups contain 1 to 6 carbon atoms.