Patents by Inventor Tadashi Kokubo
Tadashi Kokubo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9496468Abstract: The present invention aims to provide a curable resin composition which gives a cured product having a low linear expansion coefficient. The curable resin composition of the present invention contains, as essential components, (A) an organic compound having at least two carbon-carbon double bonds reactive with SiH groups per molecule, (B) a compound containing at least two SiH groups per molecule, (C) a hydrosilylation catalyst, (D) a silicone compound having at least one carbon-carbon double bond reactive with a SiH group per molecule, and (E) an inorganic filler.Type: GrantFiled: March 10, 2015Date of Patent: November 15, 2016Assignee: KANEKA CORPORATIONInventors: Tadashi Kokubo, Katsuya Ouchi, Takahisa Iwahara, Kazuhiko Hirabayashi, Hiroshi Okoshi, Tomokazu Tozawa, Shuhei Ozaki
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Patent number: 9178120Abstract: The present invention aims to provide a curable resin composition which gives a cured product having a low linear expansion coefficient. The curable resin composition of the present invention contains, as essential components, (A) an organic compound having at least two carbon-carbon double bonds reactive with SiH groups per molecule, (B) a compound containing at least two SiH groups per molecule, (C) a hydrosilylation catalyst, (D) a silicone compound having at least one carbon-carbon double bond reactive with a SiH group per molecule, and (E) an inorganic filler.Type: GrantFiled: March 30, 2011Date of Patent: November 3, 2015Assignee: KANEKA CORPORATIONInventors: Tadashi Kokubo, Katsuya Ouchi, Takahisa Iwahara, Kazuhiko Hirabayashi, Hiroshi Okoshi, Tomokazu Tozawa, Shuhei Ozaki
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Publication number: 20150188008Abstract: The present invention aims to provide a curable resin composition which gives a cured product having a low linear expansion coefficient. The curable resin composition of the present invention contains, as essential components, (A) an organic compound having at least two carbon-carbon double bonds reactive with SiH groups per molecule, (B) a compound containing at least two SiH groups per molecule, (C) a hydrosilylation catalyst, (D) a silicone compound having at least one carbon-carbon double bond reactive with a SiH group per molecule, and (E) an inorganic filler.Type: ApplicationFiled: March 10, 2015Publication date: July 2, 2015Applicant: KANEKA CORPORATIONInventors: Tadashi Kokubo, Katsuya Ouchi, Takahisa Iwahara, Kazuhiko Hirabayashi, Hiroshi Okoshi, Tomokazu Tozawa, Shuhei Ozaki
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Patent number: 9034051Abstract: A bone repair material being superior in apatite-forming ability and its stability in a storage and high in scratch resistance is disclosed. The material is produced by a method comprising the steps of: immersing a substrate made of titanium or a titanium alloy in a first aqueous solution that does not contain calcium ions but contains at least one cation selected from the group consisting of sodium ions and potassium ions and is alkaline; immersing the substrate in a second aqueous solution that does not contain phosphate ions but contains calcium ions; heating the substrate in a dry atmosphere; and treating the substrate with hot water of 60° C. or higher or with steam.Type: GrantFiled: May 23, 2013Date of Patent: May 19, 2015Assignee: ADVANCED MEDIX INC.Inventors: Tadashi Kokubo, Takashi Kizuki, Seiji Yamaguchi, Tomiharu Matsushita
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Patent number: 8784864Abstract: Bone repair materials are disclosed, from which ions are hardly eluted in living body and which are superior in apatite-forming ability and resistance to apatite peeling and have a scratch resistance high enough for practical use. The material comprises a substrate made of titanium or titanium alloys, and a surface layer, made substantially of titanium oxide, along the surface of the substrate. The substrate has on the surface thereof irregularities of from 1 nm to 10 ?m in average in both width and depth. The layer has a zeta potential of +4.5 mV or more under an aqueous solution environment of pH 6 to 8, and a critical scratch resistance of 35 mN or more when vibration 100 ?m in amplitude is added to a stylus with a spring constant of 200 g/mm on the surface layer and the stylus is moved at a rate of 10 mm/sec under a load increasing at a rate of 100 mN/min.Type: GrantFiled: January 29, 2010Date of Patent: July 22, 2014Assignees: Chubu University Educational Foundation, Osaka Yakin Kogyo Co., Ltd, Avanced Medix Inc.Inventors: Tadashi Kokubo, Tomiharu Matsushita, Deepak K. Pattanayak
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Publication number: 20130261765Abstract: A bone repair material being superior in apatite-forming ability and its stability in a storage and high in scratch resistance is disclosed. The material is produced by a method comprising the steps of: immersing a substrate made of titanium or a titanium alloy in a first aqueous solution that does not contain calcium ions but contains at least one cation selected from the group consisting of sodium ions and potassium ions and is alkaline; immersing the substrate in a second aqueous solution that does not contain phosphate ions but contains calcium ions; heating the substrate in a dry atmosphere; and treating the substrate with hot water of 60° C. or higher or with steam.Type: ApplicationFiled: May 23, 2013Publication date: October 3, 2013Applicant: ADVANCED MEDIX INC.Inventors: Tadashi Kokubo, Takashi Kizuki, Seiji Yamaguchi, Tomiharu Matsushita
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Patent number: 8475826Abstract: The titanium oxide-organic polymer composite material for artificial bone obtained by forming titania gel on the surface of said base material by titania solution treatment to dip into a solution of 0° C. to 50° C. temperature for from several seconds to 1 week obtained by adding a solution consisting of acidic alcohol and water into alcohol solution of titaniumtetraalcoxide to a base material composed of a polymer compound selected from a group consisting of polyolefin, polyester and nylon, and modifying to a titanium oxide membrane which forms apatite having similar Ca/P atom ratio to an apatite of mammalian's bone in supersaturated aqueous solution to apatite or from a body fluid of mammalian by dipping said base material on the surface of which titania gel is formed into hot water of. 50° C. to 95° C. or solution of room temperature to 95° C. to which acid is added.Type: GrantFiled: June 8, 2010Date of Patent: July 2, 2013Assignee: Japan Science & Technology AgencyInventors: Tadashi Kokubo, Masakazu Kawashita, Takashi Nakamura
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Patent number: 8470387Abstract: A bone repair material being superior in apatite-forming ability and its stability in a storage and high in scratch resistance is disclosed. The material is produced by a method comprising the steps of: immersing a substrate made of titanium or a titanium alloy in a first aqueous solution that does not contain calcium ions but contains at least one cation selected from the group consisting of sodium ions and potassium ions and is alkaline; immersing the substrate in a second aqueous solution that does not contain phosphate ions but contains calcium ions; heating the substrate in a dry atmosphere; and treating the substrate with hot water of 60° C. or higher or with steam.Type: GrantFiled: June 1, 2009Date of Patent: June 25, 2013Assignee: Advanced Medix Inc.Inventors: Tadashi Kokubo, Takashi Kizuki, Seiji Yamaguchi, Tomiharu Matsushita
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Publication number: 20130082369Abstract: The present invention aims to provide a curable resin composition which gives a cured product having a low linear expansion coefficient. The curable resin composition of the present invention contains, as essential components, (A) an organic compound having at least two carbon-carbon double bonds reactive with SiH groups per molecule, (B) a compound containing at least two SiH groups per molecule, (C) a hydrosilylation catalyst, (D) a silicone compound having at least one carbon-carbon double bond reactive with a SiH group per molecule, and (E) an inorganic filler.Type: ApplicationFiled: March 30, 2011Publication date: April 4, 2013Applicant: KANEKA CORPORATIONInventors: Tadashi Kokubo, Katsuya Ouchi, Takahisa Iwahara, Kazuhiko Hirabayashi, Hiroshi Okoshi, Tomokazu Tozawa, Shuhei Ozaki
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Publication number: 20110287070Abstract: Bone repair materials are disclosed, from which ions are hardly eluted in living body and which are superior in apatite-forming ability and resistance to apatite peeling and have a scratch resistance high enough for practical use. The material comprises a substrate made of titanium or titanium alloys, and a surface layer, made substantially of titanium oxide, along the surface of the substrate. The substrate has on the surface thereof irregularities of from 1 nm to 10 ?m in average in both width and depth. The layer has a zeta potential of +4.5 mV or more under an aqueous solution environment of pH 6 to 8, and a critical scratch resistance of 35 mN or more when vibration 100 ?m in amplitude is added to a stylus with a spring constant of 200 g/mm on the surface layer and the stylus is moved at a rate of 10 mm/sec under a load increasing at a rate of 100 mN/min.Type: ApplicationFiled: January 29, 2010Publication date: November 24, 2011Applicants: Chubu University Educational Foundation, Advanced Medix Inc., Sagawa Printing Co., Ltd.Inventors: Tadashi Kokubo, Tomiharu Matsushita, Deepak K. Pattanayak
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Publication number: 20110082562Abstract: A bone repair material being superior in apatite-forming ability and its stability in a storage and high in scratch resistance is disclosed. The material is produced by a method comprising the steps of: immersing a substrate made of titanium or a titanium alloy in a first aqueous solution that does not contain calcium ions but contains at least one cation selected from the group consisting of sodium ions and potassium ions and is alkaline; immersing the substrate in a second aqueous solution that does not contain phosphate ions but contains calcium ions; heating the substrate in a dry atmosphere; and treating the substrate with hot water of 60° C. or higher or with steam.Type: ApplicationFiled: June 1, 2009Publication date: April 7, 2011Applicant: SAGAWA PRINTING CO., LTD.Inventors: Tadashi Kokubo, Takashi Kizuki, Seiji Yamaguchi, Tomiharu Matsushita
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Patent number: 7871561Abstract: An artificial bone which is excellent in the ability to form bone in a living body, reliably thereof, and has high mechanical strength. The process comprises the steps of: mixing granules, composed of a titanium or a titanium alloy powder and an organic binder, with a particulate pore-forming material, pressure-molding the mixture to obtain a molded body, firing the molded body at 1200° C. to obtain a porous body, bringing the porous body into contact with an aqueous alkali solution, subsequently with water of 35° C. or higher for a period longer than that of contacting with the aqueous alkali solution and then heating the porous body at 100 to 650° C., preferably 200 to 600° C.Type: GrantFiled: March 22, 2006Date of Patent: January 18, 2011Assignee: Japan Science and Technology AgencyInventors: Tadashi Kokubo, Takehiro Shibuya
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Patent number: 7829196Abstract: A hard tissue repairing material includes zirconia as a base material. A surface of the base material has a hydrophilic group. The hydrophilic group is bonded to zirconium atom in the base material. The base material may contain at least an ionic component that is selected from a group consisting of calcium ion, sodium ion, potassium ion, and phosphate ions within the surface. A hard tissue repairing material may include zirconia as a base material and a layer of a main component of an apatite. The layer of the apatite may be formed on a hydrophilic group bonded to zirconium atom in the base material.Type: GrantFiled: April 8, 2009Date of Patent: November 9, 2010Assignees: Panasonic Corporation Works, Ltd.Inventors: Tadashi Kokubo, Masahiro Nawa, Masaki Uchida
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Publication number: 20100247739Abstract: The titanium oxide-organic polymer composite material for artificial bone obtained by forming titania gel on the surface of said base material by titania solution treatment to dip into a solution of 0° C. to 50° C. temperature for from several seconds to 1 week obtained by adding a solution consisting of acidic alcohol and water into alcohol solution of titaniumtetraalcoxide to a base material composed of a polymer compound selected from a group consisting of polyolefin, polyester and nylon, and modifying to a titanium oxide membrane which forms apatite having similar Ca/P atom ratio to an apatite of mammalian's bone in supersaturated aqueous solution to apatite or from a body fluid of mammalian by dipping said base material on the surface of which titania gel is formed into hot water of. 50° C. to 95° C. or solution of room temperature to 95° C. to which acid is added.Type: ApplicationFiled: June 8, 2010Publication date: September 30, 2010Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Tadashi Kokubo, Masakazu Kawashita, Takashi Nakamura
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Publication number: 20090317278Abstract: An artificial bone which is easy to bond to a living bone and has a mechanical property approximate to that of a living bone is disclosed. The artificial bone comprises: a dense part made of titanium or a titanium alloy, in the shape of a frame that is approximate to a part of an outer face of a living bone, having a density of 95% or more; and a porous part made of sintered particles of titanium or a titanium alloy having the same or different composition as the titanium alloy for the dense part, in the shape approximate to the remaining part of the living bone, having a porosity of 40% or more, the dense part and the particles of the porous part being sintered to each other at an interface between the dense part and the porous part.Type: ApplicationFiled: August 28, 2007Publication date: December 24, 2009Applicants: JAPAN SCIENCE AND TECHNOLOGY AGENCY, CHUBU UNIVERSITY EDUCATIONAL FOUNDATION, ADVANCED MEDIX INC.Inventor: Tadashi Kokubo
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Patent number: 7611781Abstract: A hard tissue repairing material includes zirconia as a base material. A surface of the base material has a hydrophilic group. The hydrophilic group is bonded to zirconium atom in the base material. The base material may contain at least an ionic component that is selected from a group consisting of calcium ion, sodium ion, potassium ion, and phosphate ions within the surface. A hard tissue repairing material may include zirconia as a base material and a layer of a main component of an apatite. The layer of the apatite may be formed on a hydrophilic group bonded to zirconium atom in the base material.Type: GrantFiled: October 31, 2000Date of Patent: November 3, 2009Assignees: Panasonic Electric Works Co., Ltd.Inventors: Tadashi Kokubo, Masahiro Nawa, Masaki Uchida
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Publication number: 20090270998Abstract: An artificial bone which is excellent in the ability to form bone in a living body, reliably thereof, and has high mechanical strength. The process comprises the steps of: mixing granules, composed of a titanium or a titanium alloy powder and an organic binder, with a particulate pore-forming material, pressure-molding the mixture to obtain a molded body, firing the molded body at 1200° C. to obtain a porous body, bringing the porous body into contact with an aqueous alkali solution, subsequently with water of 35° C. or higher for a period longer than that of contacting with the aqueous alkali solution and then heating the porous body at 100 to 650° C., preferably 200 to 600° C.Type: ApplicationFiled: March 22, 2006Publication date: October 29, 2009Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Tadashi Kokubo, Takehiro Shibuya
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Publication number: 20090191280Abstract: A hard tissue repairing material includes zirconia as a base material. A surface of the base material has a hydrophilic group. The hydrophilic group is bonded to zirconium atom in the base material. The base material may contain at least an ionic component that is selected from a group consisting of calcium ion, sodium ion, potassium ion, and phosphate ions within the surface. A hard tissue repairing material may include zirconia as a base material and a layer of a main component of an apatite. The layer of the apatite may be formed on a hydrophilic group bonded to zirconium atom in the base material.Type: ApplicationFiled: April 8, 2009Publication date: July 30, 2009Applicants: MATSUSHITA ELECTRIC WORKS, LTD.Inventors: Tadashi KOKUBO, Masahiro NAWA, Masaki UCHIDA
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Publication number: 20090051082Abstract: A method for producing an artificial bone precursor is disclosed. The method comprises: extracting a part corresponding to a cancellous bone and/or a cortical bone from digitalized three-dimensional image data of a living bone, followed by setting a center line on the part; drawing a beam or a wall having a uniform diameter or thickness along the center line to form artificial bone image data; and stacking a sintered layer by laser-sintering a powder of titanium and the like based on the artificial bone image data. The precursor is suitable for an artificial bone having excellent osteoconductivity and osteoinductivity.Type: ApplicationFiled: March 16, 2007Publication date: February 26, 2009Applicants: SAGAWA PRINTING CO., LTD., KYOTO UNIVERSITY, CHUBU UNIVERSITY EDUCATIONAL FOUNDATIONInventors: Takashi Nakamura, Tadashi Kokubo, Tomiharu Matsushita, Shunsuke Fujibayashi, Nobukatsu Nishida
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Publication number: 20080227905Abstract: The object of the present invention is to provide a thermoplastic elastomer composition having a good balance between the hardness and the mechanical strength, exhibiting superior rubber elasticity, high-temperature creep characteristics and formability in a wide range of temperature, and having oil resistance and heat resistance. The thermoplastic elastomer composition comprises (A) (meth)acrylic block copolymer; (B) a compound containing at least two amino groups in its molecule; and (C) a thermoplastic resin. The (meth)acrylic block copolymer (A) comprises (A1) a (meth)acrylic copolymer block and (A2) an acrylic copolymer block. A1 least one of the polymer blocks has at least one acid anhydride group. The (meth)acrylic block copolymer (A) and the compound (B) are dynamically vulcanized in the thermoplastic resin (C).Type: ApplicationFiled: March 5, 2004Publication date: September 18, 2008Inventors: Atsushi Kumasaki, Akio Taniguchi, Tadashi Kokubo, Takeshi Chiba