Abstract: Disclosed is a method for stabilizing a solid pharmaceutical preparation containing a pharmacological substance and sodium lauryl sulfate, the method comprising incorporating into the preparation at least one member selected from the group consisting of neutral salts, basic salts and basic substances. The preparation containing sodium lauryl sulfate prepared by the method of the invention has superior performance, including high storage stability, suppression of discoloration and deterioration, and prevention of change in its properties, such as the dissolution rate of pharmacological substance from the preparation.

Abstract: The subject invention provides a novel pharmaceutical solid preparation that has superior disintegration properties and excellent solubility, leading to sufficient absorbability of active ingredients through the gastrointestinal tract. The pharmaceutical solid preparation of the present invention comprises: (a) 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzoazepine and/or salt thereof; (b) hydroxypropylcellulose containing a hydroxypropoxyl group in an amount of 50 wt. % or greater; and (c) at least one member selected from the group consisting of carmellose, sodium carboxy methyl starch, crospovidone, and low substituted hydroxypropylcellulose with an average particle diameter of 30 to 70 ?m, and a 90% cumulative particle diameter of 100 to 200 ?m.

Abstract: The present invention provides an orally disintegrating powder comprising cilostazol as an active ingredient and mannitol in an amount of 70% by weight or more, which can be taken without water and can be disintegrated in oral cavity. Said powder is suitable for patients to whom cilostazol is applied, especially for aged patients and patients suffering from dysphagia.

Abstract: The present invention provides a highly accurate method for monitoring patient or subject compliance with a medication prescription by collecting a sample of the exhaled air. The method of the present invention is easy and little burdens the patient or subject. The method comprises the steps of: (i) prescribing a patient or subject ingestion of at least one biologically active agent and at least one carbon isotope-labeled lipid, (ii) obtaining a sample of the patient's or subject's exhaled air, (iii) measuring the ratio of the carbon isotope-labeled CO2 relative to 12CO2 in the sample; and (iv) confirming the ingestion of the prescribed biologically active agent based on the ratio of the carbon isotope-labeled CO2 relative to 12CO2.

Abstract: An object of the present invention is to provide an oral preparation that can be used to diagnose the existence or degree of pyridine metabolic capacity disorder, pyrimidine metabolic rate, etc., with high accuracy and with little variation due to individual differences. The oral preparation is prepared using a powder material obtained by mixing and pulverizing (a) an isotope-labeled compound and/or a pyrimidine metabolite compound and (b) a sugar and/or a sugar alcohol.

Abstract: This invention provides a solid pharmaceutical formulation having high physical strength and further having excellent drug release properties and digestibility of excipients when administered, which comprises (a) an active medical ingredient and (b) a pre-gelatinized starch in an amount of 10 to 90% by weight, said pre-gelatinized starch being prepared by pre-gelatinizing a cheap and stable usual starch during the procedure for formulation. This invention also provides a method for preparing the solid pharmaceutical formulation.

Abstract: Provided is a cilostazol preparation which comprises incorporating a fine powder of cilostazol into a dispersing and/or solubilizing agent thereby to enhance the dispersibility and/or solubility. Further, provided is a process for improving absorbability of a slightly soluble drug such as cilostazol even at the lower portion of the digestive tract, wherein said drug is hard to be absorbed at the lower portion of the digestive tract when a conventional method is used. According to the present invention, cilostazol is absorbed enough even at the lower portion of the digestive tract to have an effect as thrombolytic drug, cerebral circulation improving drug or the like.

Abstract: A coating dispersion soluble in the lower digestive tract which is prepared by blending a hydroxypropyl methylcellulose acetate succinate (HPMCAS) soluble at around pH 7 with a conventional plasticizer and an anion surfactant and further adding an acid, wherein the HPMCAS has an average particle size of 10 ?m or less and is dispersed at a concentration of 2 to 20% by weight, and the acid is used in an amount of 1 to 10 parts by weight per 100 parts by weight of HPMCAS, and a sustained release coated preparation capable of releasing a medicament in the large intestine at the lower digestive tract, which is prepared by coating a medicament-containing solid preparation such as a granular core with the coating dispersion.

Abstract: The present invention provides a highly accurate method for monitoring patient or subject compliance with a medication prescription by collecting a sample of the exhaled air. The method of the present invention is easy and little burdens the patient or subject. The method comprises the steps of: (i) prescribing a patient or subject ingestion of at least one biologically active agent and at least one carbon isotope-labeled lipid, (ii) obtaining a sample of the patient's or subject's exhaled air, (iii) measuring the ratio of the carbon isotope-labeled CO2 relative to 12CO2 in the sample; and (iv) confirming the ingestion of the prescribed biologically active agent based on the ratio of the carbon isotope-labeled CO2 relative to 12CO2.

Abstract: Disclosed is a method for stabilizing a solid pharmaceutical preparation containing a pharmacological substance and sodium lauryl sulfate, the method comprising incorporating into the preparation at least one member selected from the group consisting of neutral salts, basic salts and basic substances. The preparation containing sodium lauryl sulfate prepared by the method of the invention has superior performance, including high storage stability, suppression of discoloration and deterioration, and prevention of change in its properties, such as the dissolution rate of pharmacological substance from the preparation.

Abstract: Disclosed is a cilostazol dry coated tablet which comprises (A) a core portion containing cilostazol and (B) an outer layer portion containing cilostazol, a water-insoluble substance and a hydrophilic hydrogel forming substance. Said tablet is a new type of preparation capable of suppressing an undesirable rise of the maximum blood concentration of cilostazol while it maintains an adequate blood concentration of cilostazol by continuously releasing, for hours, only a required amount of cilostazol for obtaining a desired drug efficacy of cilostazol.

Abstract: A current location updating display for indicating the current location of moving members such as an automobile while updating from time to time based on output from a magnetic azimuth sensor adapted to detect the azimuth of terrestrial magnetism. Output signals from the magnetic azimuth sensor are stored in a data memory after A/D conversion and correction, and a predetermined amount of data read out from the data memory is subject to the averaging processing. With this, plural angle information (sin .theta. and cos .theta.) signals or plural angle (.theta.) signals are averaged out including a signal corresponding to disturbance magnetism. Thus average data signals are integrated by an integrator and then sent to a display portion. Through the averaging processing an azimuthal error is restrained as small as possible, so that the current location or running path of the moving member may be indicated correctly.

Abstract: In a course guidance system for use in an automobile, for example, which includes an electronic display, a map, a direction sensor, a speed sensor and the like for deriving the present location of the car and plotting it on the display, the invention provides a course guidance system for a car which causes a linear and/or rotational movement of the driving locus displayed on the display when the map is changed or reset so that the present position can be easily located on the map.

Abstract: A course guidance system includes a direction sensor and a speed sensor both fitted to a moving body, a display mounted in the moving body and a map displayed in a manner corresponding to the display surface of the display and in which the present position of the moving body is derived by the direction sensor and the speed sensor and is plotted on the display in a manner corresponding to the map.

Abstract: Disclosed is a magnetic course detector capable of accurately detecting the bearing of the course of a traveling body independently of the position a magnetic bearing sensor is installed in the traveling body through rotatably mounting the magnetic bearing sensor and making corrections for the offset and sensitivity of its output.