Patents by Inventor Tadashi Okawara

Tadashi Okawara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic Agent for Type 2 Diabetes
    Publication number: 20160060235
    Abstract: An object of the present invention is to provide a novel therapeutic agent for a patient with type 2 diabetes, a cause of which is the abnormal synthesis of insulin attributed to the abnormal modification of tRNALys (UUU) in pancreatic ? cells having Cdkal1 gene mutation. The present inventors have used (1) a screening system using E. coli in which correct translation into luciferase requires frameshift resulting from mistranslation during protein translation, (2) a screening system using the pancreatic islet of Langerhans isolated from a pancreatic ? cell-specific Cdkal1-deficient mouse, and (3) a screening system using a pancreatic ? cell-specific Cdkal1-deficient mouse, and found that a compound represented by any of the following formulas (I) to (III) can serve as a therapeutic agent for a patient with type 2 diabetes with Cdkal1 gene mutation resulting in the reduced ability to secrete insulin.
    Type: Application
    Filed: March 28, 2014
    Publication date: March 3, 2016
    Inventors: Kazuhito Tomizawa, Fanyan Wei, Kengo Inoue, Tadashi Okawara
  • 1,3,4-Oxadiazole-2-carboxamide compound
    Patent number: 8796320
    Abstract: Provided is a 1,3,4-oxadiazole-2-carboxamide compound which has STAT3 inhibitory activity and is useful as an anticancer agent. Provided is a 1,3,4-oxadiazole-2-carboxamide compound represented by formula (I) or a pharmacologically acceptable salt thereof (in the formula, Ar represents a furyl group or the like; R1 represents a hydrogen atom or the like; and —X—Y represents a diaryl group such as a biphenyl group).
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: August 5, 2014
    Assignees: General Incorporated Association Pharma Valley Project Supporting Organization, Pharma Design, Shizuoka Prefecture, Kumamoto Health Science University, Kabushiki Kaisha Yakult Honsha
    Inventors: Akira Asai, Kenji Matsuno, Naohisa Ogo, Osamu Takahashi, Yoshiaki Masuda, Ayumu Muroya, Yasuto Akiyama, Tadashi Ashizawa, Tadashi Okawara
  • STAT3 inhibitor containing quinolinecarboxamide derivative as active ingredient
    Patent number: 8466290
    Abstract: The present invention provides a STATS inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and R1 to R8 and R34 each represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like), or a pharmacologically acceptable salt thereof.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: June 18, 2013
    Assignees: Pharma IP General Incorporated Association, Pharma Design, Inc., Shizuoka Prefecture, Kumamoto Health Science University, Kabushiki Kaisha Yakult Honsha
    Inventors: Akira Asai, Kenji Matsuno, Naohisa Ogo, Takane Yokotagawa, Osamu Takahashi, Yasuto Akiyama, Tadashi Ashizawa, Tadashi Okawara
  • 1,3,4-OXADIAZOLE-2-CARBOXAMIDE COMPOUND
    Publication number: 20120302524
    Abstract: Provided is a 1,3,4-oxadiazole-2-carboxamide compound which has STAT3 inhibitory activity and is useful as an anticancer agent. Provided is a 1,3,4-oxadiazole-2-carboxamide compound represented by formula (I) or a pharmacologically acceptable salt thereof (in the formula, Ar represents a furyl group or the like; R1 represents a hydrogen atom or the like; and —X—Y represents a diaryl group such as a biphenyl group).
    Type: Application
    Filed: December 28, 2010
    Publication date: November 29, 2012
    Applicants: GENERAL INCORPORATED ASSOCIATION PHARMA VALLEY PROJECT SUPPORTING ORGANIZATION, PHARMA DESIGN, INC., KABUSHIKI KAISHA YAKULT HONSHA, KUMAMOTO HEALTH SCIENCE UNIVERSITY, SHIZUOKA PREFECTURE
    Inventors: Akira Asai, Kenji Matsuno, Naohisa Ogo, Osamu Takahashi, Yoshiaki Masuda, Ayumu Muroya, Yasuto Akiyama, Tadashi Ashizawa, Tadashi Okawara
  • STAT3 INHIBITOR CONTAINING QUINOLINECARBOXAMIDE DERIVATIVE AS ACTIVE INGREDIENT
    Publication number: 20110172429
    Abstract: The present invention provides a STATS inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and R1 to R8 and R34 each represent H, halogen, alkyl, phenyl, furyl, thienyl, or the like.), or a pharmacologically acceptable salt thereof.
    Type: Application
    Filed: July 10, 2009
    Publication date: July 14, 2011
    Applicants: PHARMA IP GENERAL INCORPORATED ASSOCIATION, PHARMA DESIGN, INC., SHIZUOKA PREFECTURE, KUMAMOTO HEALTH SCIENCE UNIVERSITY, KABUSHIKI KAISHA YAKULT HONSHA
    Inventors: Akira Asai, Kenji Matsuno, Naohisa Ogo, Takane Yokotagawa, Osamu Takahashi, Yasuto Akiyama, Tadashi Ashizawa, Tadashi Okawara