Abstract: A device for efficiently attaching a sheet-shaped object to a target site includes a support body for supporting a sheet-shaped object, and a protective member having a low coefficient of friction for protecting one surface of the support, in which the support body supporting the sheet-shaped object is rolled while being protected by the protective member and can be inserted into a tubular body.

Abstract: Disclosed are a cell processing method, a device, and a robot system that has a simple constitution and are reasonable. A robot system is provided for injecting liquid by rotating an injection container containing the liquid and an injection volume of the liquid is constant around an axis vertical to a long axis of the injection container. The robot system executes an injection start control to rotate the injection container around a predetermined axis, an injection control to stop rotation for a predetermined time and inject the liquid, and an injection end control to reversely rotate the injection container around the predetermined axis, and the predetermined time is calculated based on an injection flow rate measured in real time.

Abstract: Disclosed are methods of preparing a high-quality sheet-shaped cell culture by preventing breakage of a sheet-shaped cell culture that is caused by adhesion, sticking and/or shrinkage of the sheet-shaped cell culture as a result of detaching, transferring or preserving the sheet-shaped cell culture. Also disclosed are methods of detaching, cleaning, and/or preserving a sheet-shaped cell culture, including soaking a sheet-shaped cell culture in a low nutrient isotonic solution.

Abstract: An object of the present invention is to provide a cell sheet embedding agent, which makes it possible to stably transport a cell sheet at the time of transport at a low temperature and to collect the cell sheet from the cell sheet embedding agent in a simple manner after being transported, a cell sheet-containing composition, and a kit. According to the present invention, there is provided a cell sheet embedding agent containing a polypeptide represented by the following Formula 1, in which in a case where a molecular weight distribution of the polypeptide is measured, a peak area of a maximum molecular weight is equal to or greater than 80% of the total peak area of all molecular weights. A-[(Gly-X—Y)n]m—B??Formula 1: In the formula, X and Y each independently represent an amino acid, m is an integer of 2 to 10, n is an integer of 3 to 100, and A and B each represent any amino acid or any amino acid sequence.

Abstract: An object of the present invention is to provide a cell sheet embedding agent, which makes it possible to stably transport a cell sheet at the time of transport at a low temperature and to collect the cell sheet from the cell sheet embedding agent in a simple manner after being transported, a cell sheet-containing composition, and a kit. According to the present invention, there is provided a cell sheet embedding agent containing a polypeptide represented by the following Formula 1, in which in a case where a molecular weight distribution of the polypeptide is measured, a peak area of a maximum molecular weight is equal to or greater than 80% of the total peak area of all molecular weights. A-[(Gly-X—Y)n]m—B??Formula 1: In the formula, X and Y each independently represent an amino acid, m is an integer of 2 to 10, n is an integer of 3 to 100, and A and B each represent any amino acid or any amino acid sequence.

Abstract: An object of the present invention is to provide a laminate containing a cell sheet which has hardness and is easy to handle at the time of transplantation or transport, an agent for treating cardiac diseases using the laminate, and a film for being laminated on a cell sheet. According to the present invention there are provided a laminate including a biocompatible polymer film having a density of 500 ?g/cm2 to 10 mg/cm2 and a cell sheet disposed on at least one surface of the biocompatible polymer film, an agent for treating cardiac diseases using the laminate, and a film for being laminated on a cell sheet.

Abstract: An information processing apparatus and a method for performing speech training in speech rehabilitation are disclosed. A report about content to be uttered in an utterance training is made to a trainee of the utterance training and the volume of a voice uttered by the trainee in response to the report is obtained. Then, the result of comparison between the obtained volume and a volume predetermined as a target volume is reported.

Abstract: A method for treating a disease associated with tissue abnormality in a subject. The method includes administering an amount of a pharmaceutical composition to a subject in need of treating a disease associated with tissue abnormality, the pharmaceutical composition comprising a laminate comprising a fibrin gel and a cell culture. The laminate is produced by a method, which includes forming a fibrin gel layer on an upper surface of the cell culture by a reaction between fibrinogen and thrombin, wherein: the cell culture is prepared on a culture dish and the laminate of the fibrin gel and the cell culture are transferred onto a subject's heart. The laminate further includes a reinforcing portion made of a fibrin gel, the reinforcing portion formed by laminating the fibrin gel on the fibrin gel layer of the laminate of the cell culture and the fibrin gel.

Abstract: A laminate of a sheet-shaped cell culture is disclosed, which has excellent operability and is suitable for implantation. A method is disclosed for producing a laminate of a fibrin gel and a sheet-shaped cell culture, including a step of dripping a liquid containing fibrinogen onto an upper surface of a sheet-shaped cell culture, a step of spraying a liquid containing thrombin onto the surface, and a step of forming a fibrin gel layer on the surface by a reaction between fibrinogen and thrombin; and a laminate of a fibrin gel and a sheet-shaped cell culture produced by the method are disclosed.

Abstract: A laminate of a sheet-shaped cell culture is disclosed, which has excellent operability and is suitable for implantation. A method is disclosed for producing a laminate of a fibrin gel and a sheet-shaped cell culture, including a step of dripping a liquid containing fibrinogen onto an upper surface of a sheet-shaped cell culture, a step of spraying a liquid containing thrombin onto the surface, and a step of forming a fibrin gel layer on the surface by a reaction between fibrinogen and thrombin; and a laminate of a fibrin gel and a sheet-shaped cell culture produced by the method are disclosed.

Abstract: A speech rehabilitation assistance apparatus is disclosed, which can execute effective speech rehabilitation of, for example, a dysarthric speaker. The speech rehabilitation assistance apparatus can include a specification section specifying a target phoneme type and specifying at least one of a word head, a word middle, and a word end as a position of the specified phoneme type, a presentation section presenting a word selected from words having the specified phoneme type in the specified position, a voice recognition section recognizing a voice uttered when a trainee reads out the presented word, and a provision section providing an evaluation value concerning the voice uttered by the trainee based on history of a recognition result by the voice recognition section.

Abstract: An information processing apparatus and a method for performing speech training in speech rehabilitation are disclosed. A report about content to be uttered in an utterance training is made to a trainee of the utterance training and the volume of a voice uttered by the trainee in response to the report is obtained. Then, the result of comparison between the obtained volume and a volume predetermined as a target volume is reported.

Abstract: An information processing apparatus is disclosed having a storage unit storing a plurality of training text items each including a word, a word string, or a sentence. The information processing apparatus presents a training text item among the plurality of training text items stored in the storage unit as voice output or character string display and calculates the speaking speed based on a voice signal that is input after presenting the training text item. The information processing apparatus compares the calculated speaking speed with a preset target speaking speed and reports the comparison result.

Abstract: There is proposed an apparatus for isolating and recovering an objective cell, which comprises, a filtering device having a filtering member which is capable of setting a porosity thereof to two or more different porosity, a first line for feeding a priming liquid to the filtering device, a second line for feeding a liquid to be treated containing the cell aimed to isolate to the filtering device, and a third line provided with a storage container for storing the priming liquid that has been passed through the filtering device, wherein the priming liquid stored in the storage container is employed for washing the filtering device. There is also proposed a method for isolating and recovering an objective cell using the aforementioned apparatus.

Abstract: A method of separating cells from blood by using a filter apparatus having first and second ports and a filter member therebetween having a changeable porosity. The filter member includes a stack of porous polymer sheets that preferably has a gradient of a physical or chemical characteristic in the direction of stacking. This can include a gradient in porosity, hydrophilicity or zeta potential. In a first step, blood is filtered through the apparatus when the filter member is set to a compressive state having a first porosity capable of capturing the objective cells. In a later step, the filter member is then set to a non-compressive state having a second porosity, higher than the first, for recovering the objective cells. The change in porosity results from the enlargement or reduction of the diameter of the pores of the filter member. The method can also include washing the filter member when the member is set to a porosity that is higher than the first porosity but lower than the second porosity.

Abstract: A body fluid purification medium comprises a support, and an adsorbent including at least one sulfa drug and fixed on a surface of said insoluble support for adsorbing and removing a pathogenic substance in a body fluid. The medium can be provided in a body fluid flow path provided in a container between body fluid inlet and outlet ports.

Abstract: For the treatment of various diseases including autoimmune diseases such as myathenia gravis, articular rhematism, lupus erythematosus, etc., immunity-related diseases such as glumerulonephritis, bronchial asthma, polyneuritis, etc., organ transplantation such as transplanted kidney rejection, AOB incompatibility bone marrow transplantation, etc., tumor, hypertension, and hepatic insufficiency, immunoglobulin adsorbents comprising a hydroxyl-containing water-insoluble carrier to which a diamine compound having the general formula:NH.sub.2 (CH.sub.2).sub.n NH.sub.2wherein n is an integer having a value of 3 to 9 is attached through a silane coupling agent or a derivative thereof, to which diamine a heterocyclic compound is attached through a difunctional reagent, are useful as they can selectively and efficiently adsorb specific proteins such as immunoglobulins and immune complexes which are pathogenic substances in the diseases, exhibit minimized non-specific adsorption, and are safe and easy to sterilize.