Abstract: Carboxamide derivatives of the following general formula (I): ##STR1## (wherein R.sup.1 and R.sup.2 are C.sub.1 -C.sub.3 alkyl group or both taken together C.sub.1 -C.sub.3 alkylene group,R.sup.3 is hydrogen atom, dialkylamino group, etc.,R.sup.4 is hydrogen atom, C.sub.1 -C.sub.10 alkyl group,R.sup.5 is C.sub.1 -C.sub.10 alkyl group,m, n, q are an integer from 0-3,p is 0, 1,A ring is ##STR2## B ring is 5 or 6 membered nitrogen containing aromatic ring, are provided, which are useful as medicinals for treating hyperlipemia or atherosclerosis.

Abstract: A novel pyrrolealdehyde derivative represented by the following formula (I): ##STR1## wherein R represents C.sub.10 -C.sub.16 alkyl unsubstituted or substituted by at least one substituent selected from the group consisting of halo, hydroxy, amino, carbamoyl, C.sub.1 -C.sub.5 alkylamino, C.sub.2 -C.sub.6 dialkylamino, C.sub.2 -C.sub.6 acylamino, C.sub.1 -C.sub.5 alkylthio, mercapto, C.sub.2 -C.sub.6 acyloxy, carbamoyloxy, C.sub.6 -C.sub.12 aryl and C.sub.3 -C.sub.7 cycloalkyl; or C.sub.10 -C.sub.16 alkenyl having at least one vinyl, and a pharmaceutically acceptable salt thereof are provided. The compounds are highly effective in reducing the level of triglyceride and cholesterol in serum, and useful as an active ingredient of a pharmaceutical composition for treating hyperlipemia and arteriosclerosis.

Abstract: Novel pyrrolecarboxylic acid derivatives represented by the following formula: ##STR1## where R.sup.1 is a hydrogen atom, an alkyl group of 5 to 25 carbon atoms or an alkenyl group of 5 to 25 carbon atoms, R.sup.2 is a hydrogen atom, a phenyl group or an optionally substituted alkyl group of 1 to 10 carbon atoms, and R.sup.3 is a hydrogen atom, an alkyl group of 5 to 25 carbon atoms or an alkenyl group of 5 to 25 carbon atoms, or pharmaceutically acceptable salts thereof are provided.The compounds are highly effective in reducing the level of triglyceride or cholesterol in serum, and useful as an active ingredient of a pharmaceutical composition for treating hyperlipemia and arteriosclerosis.

Abstract: A process for preparing cotarnine is provided which comprises oxidizing the amino group of a tetrahydroisoquinoline compound represented by the following formula (I): ##STR1## to convert said compound into a dihydroisoquinolinium salt represented by the following formula (II): ##STR2## wherein A.sup.- represents an anion, and then hydrolyzing said dihydroisoquinolinium salt.

Abstract: There is provided a novel benzylamine derivative of the formula I: ##STR1## wherein R.sup.1 represents a hydrogen atom or a methyl group, X represents a hydrogen atom, a methyl group or a tosyl group, and Y represents a hydrogen atom, a methyl group or ##STR2## in which R.sup.2 and R.sup.3 being identical or different from each other represent independently a lower alkyl group.

Abstract: A tetrahydroisoquinoline derivative represented by formula: ##STR1## wherein R.sup.1 represents hydrogen or methyl and X.sup.1, X.sup.2, Y.sup.1 and Y.sup.2 are defined as follows:(1) X.sup.1 represents --OH, ##STR2## or OR.sup.2 wherein R.sup.2 represents lower alkyl when X.sup.2, Y.sup.1 and Y.sup.2 represent hydrogen(2) X.sup.1 and X.sup.2 together form oxo (.dbd.O), when Y.sup.1 and Y.sup.2 represent hydrogen or(3) Y.sup.1 and Y.sup.2 together form oxo (.dbd.O), when X.sup.1 and X.sup.2 represent hydrogen which is useful as an intermediate in preparation of Cotarnine.

Abstract: There is provided a novel anisole derivative represented by the following formula (I): ##STR1## wherein A to D are defined as follows: (1) A, B and C are each a hydrogen atom, and D represents --OH, a halogen atom, --CO.sub.2 R.sup.1 of which R.sup.1 represents a lower alkyl group, --SO.sub.2 R.sup.2 of which R.sup.2 represents a lower alkyl group, or ##STR2## or (2) A and C are each a hydrogen atom, B is --OH, and D represents --CO.sub.2 R.sup.3 of which R.sup.3 represents a lower alkyl group; or(3) A is a hydrogen atom, B and C form an oxo group .dbd.O together, and D represents --CO.sub.2 R.sup.4 of which R.sup.4 represents a lower alkyl group; or(4) B and C are each a hydrogen atom, D is a halogen atom, and A represents --CHO.

Abstract: Amino acid derivatives of 6-(2-amino-2-arylacetamido)penicillanic acids are prepared and shown to be useful as antibacterial agents.

Abstract: Amino acid derivatives of 6-(2-amino-2-arylacetamido) penicillanic acids are prepared and shown to be useful as antibacterial agents.

Abstract: 6-(2-ACYLAMINO-2-ARYLACETAMIDO)PENICILLANIC ACIDS ARE PREPARED AND SHOWN TO BE USEFUL AS ANTIBACTERIAL AGENTS.

Abstract: Amino acid derivatives of 6-(2-amino-2-arylacetamido)penicillanic acids are prepared and shown to be useful as antibacterial agents.

Abstract: Novel pyrrolecarboxylic acid derivatives represented by the following formula: ##STR1## where R.sup.1 is a hydrogen atom, an alkyl group of 5 to 25 carbon atoms or an alkenyl group of 5 to 25 carbon atoms, R.sup.2 is a hydrogen atom, a phenyl group or an optionally substituted alkyl group of 1 to 10 carbon atoms, and R.sup.3 is a hydrogen atom, an alkyl group of 5 to 25 carbon atoms or an alkenyl group of 5 to 25 carbon atoms, or pharmaceutically acceptable salts thereof are provided.The compounds are highly effective in reducing the level of triglyceride or cholesterol in serum, and useful as an active ingredient of a pharmaceutical composition for treating hyperlipemia and arteriosclerosis.