Patents by Inventor Tadashiro Fujii
Tadashiro Fujii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 4613666Abstract: Neplanocin A derivatives of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or benzoyl, R.sub.3 is hydrogen or OR.sub.8, R.sub.5 is hydrogen or acetyl, R.sub.6 is hydrogen, acetyl or benzoyl, when R.sub.3 is hydrogen, R.sub.4 is hydrogen or halogen, hydroxy, acetoxy, acetylthio, amino or azide, and when R.sub.3 is OR.sub.8, R.sub.4 is hydrogen, R.sub.8 is hydrogen or acetyl, or R.sub.8 and R.sub.5 together form benzylidene, and at least one of R.sub.8, R.sub.5 and R.sub.6 is other than hydrogen. The compounds of the present invention have inhibitory action for the growth of L 5178 Y cells and have the same or superior activity as neplanocin A, and hence are useful as antitumor agents.Type: GrantFiled: September 16, 1985Date of Patent: September 23, 1986Assignee: Toyo Jozo Kabushiki KaishaInventors: Kiyofumi Fukukawa, Takao Hirano, Masatoshi Tsujino, Tooru Ueda, Tadashiro Fujii, Satoshi Yaginuma
-
Patent number: 4423218Abstract: Antibiotic neplanocin A of the formula ##STR1## is produced by culturing Ampullariella sp. A 11079 FERM-P No. 4494 in a nutrient medium and then separating the neplanocin A thus produced from the culture medium.Type: GrantFiled: November 3, 1980Date of Patent: December 27, 1983Assignee: Toyo Jozo Kabushiki KaishaInventors: Masaru Otani, Satoshi Yaginuma, Masatoshi Tsujino, Naoki Muto, Tetsu Saito, Tadashiro Fujii
-
Patent number: 4384041Abstract: Novel amine compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl and R.sub.2 is substituted methyl amino or D-amino acid residue, or a salt thereof. R.sub.1 can typically be isobutyl or methyl; and R.sub.2 can be methylamino of the formula--NH--CH.sub.2 --R.sub.3in which R.sub.3 is organic, more particularly methyl, ethyl, n-propyl, isopropyl, n-butyl, amyl, p-hydroxybenzyl, 3,4-di-hydroxybenzyl, 5-imidazolemethyl, 3-imidazolemethyl or phenyl. R.sub.2 can also be D-amino acid residue of the formula ##STR2## in which one of R.sub.4 and R.sub.5 is carboxyl and the other is organic, more particularly methylthioethyl, isobutyl, methyl or phenyl, and C* is a D-asymmetric carbon atom. The compounds are useful in an assay method for leucine and aminopeptidase which comprises reacting a substrate amide as above, or a salt thereof, with a sample for leucine aminopeptidase assay, incubating the reaction product produced thereby, and measuring the thus-consumed oxygen or liberated hydrogen peroxide.Type: GrantFiled: April 7, 1981Date of Patent: May 17, 1983Assignee: Toyo Jozo Kabushiki KaishaInventors: Kunio Matsumoto, Toshiharu Noda, Tadashiro Fujii, Susumu Watanabe, Kazuhiko Matsumoto, Shigeo Katsuragi
-
Patent number: 4349667Abstract: Aminoglycoside antibiotic G-367-2 believed to have the formula ##STR1## is produced by culturing Dactylosporangium thailandense G-367 FERM-P No. 4840 in a nutrient medium and separating the produced antibiotic therefrom. It has strong antibacterial effect against Gram negative bacteria.Type: GrantFiled: July 9, 1980Date of Patent: September 14, 1982Assignee: Toyo Jozo Kabushiki KaishaInventors: Tadashiro Fujii, Shuzo Satoi, Naoki Muto, Mitsuo Hayashi, Akira Kodama, Masaru Otani
-
Patent number: 4321376Abstract: Neplanocin-B and -F of the formula ##STR1## in which Y is oxygen or a valence bond, are produced by culturing Ampullariella sp. A 11079 FERM-P No. 4494 in a nutrient medium and then separating the neplanocin-B and -F thus produced from the culture medium.Type: GrantFiled: December 7, 1979Date of Patent: March 23, 1982Assignee: Toyo Jozo Kabushiki KaishaInventors: Masaru Otani, Satoshi Yaginuma, Masatoshi Tsujino, Naoki Muto, Tetsu Saito, Tadashiro Fujii
-
Patent number: 4297486Abstract: Aminoglycoside antibiotic G-367-1 believed to have the formulae ##STR1## is produced by culturing Dactylosporangium thailandense G-367 FERM-P No. 4840 in a nutrient medium and separating the produced antibiotic therefrom. It has strong antibacterial effect against Gram negative bacteria.Type: GrantFiled: April 3, 1980Date of Patent: October 27, 1981Assignee: Toyo Jozo Kabushiki KaishaInventors: Tadashiro Fujii, Shuzo Satoi, Naoki Muto, Mitsuo Hayashi, Akira Kodama, Masaru Otani
-
Patent number: 4291021Abstract: A novel microorganism species belonging to the genus Micromonospora, i.e. Micromonospora sp. A 11725 is found to be capable of producing novel macrolide antibiotics A 11725 I, A 11725 II and A 11725 III. Novel antibiotics A 11725 Ia and A 11725 IIa are also found to be derived by chemical modification of the antibiotics A 11725 I and A 11725 II, respectively. All of these antibiotics or salts thereof exhibit excellent antibacterial and anti-mycoplasmal activities against various microorganisms such as Staphylococcus or Mycoplasma, and therefore useful for various purposes including medicaments.Type: GrantFiled: May 10, 1979Date of Patent: September 22, 1981Assignee: Toyo Jozo Company, Ltd.Inventors: Masaru Otani, Shuzo Satoi, Naoki Muto, Tetsu Saito, Tadashiro Fujii, Seiji Katsumata, Mitsuo Hayashi, Masaru Ono
-
Patent number: 4288429Abstract: A group of sulfur-containing antibiotics, planothiocin-A, -B, -C, -D, -E, -F and -G, are produced by culturing Actinoplanes sp. A12526 in a nutrient medium, and separating the thus-produced planothiocins therefrom. The novel antibiotics have utility in therapeutic or prophylactic antibacterial compositions or feed additives for livestock, poultry or fish.Type: GrantFiled: August 5, 1980Date of Patent: September 8, 1981Assignee: Toyo Jozo Kabushiki KaishaInventors: Tadashiro Fujii, Satoshi Yaginuma, Naoki Muto, Mitsuo Hayashi
-
Patent number: 4287345Abstract: A polyfunctional disulfide compound, useful as a cross-linking reagent having S--S exchange reactivity, of the formula ##STR1## wherein R is 2-benzothiazolyl or 2-pyridyl-N-oxide and X is a spacer group having an alkylene group directly bonded to each S--S group.Type: GrantFiled: January 11, 1980Date of Patent: September 1, 1981Assignee: Toyo Jozo Kabushiki KaishaInventors: Kikuo Kotani, Kunio Ohyama, Nobuaki Nakagawa, Tadashiro Fujii, Susumu Watanabe
-
Patent number: 4258193Abstract: A disulfide derivative, having S--S exchange reactivity, of the formulaR.sub.1 --S--S--R.sub.2 --CO--R.sub.3).sub.n R.sub.4 [I]wherein R.sub.1 is 2-benzothiazolyl or 2-pyridyl-N-oxide, R.sub.2 is alkylene having optionally free or protected functional groups, R.sub.3 is the carboxyl residue of an amino acid or lower polypeptide, R.sub.4 is carboxyl or a reactive derivative thereof or protected carboxyl or imidate, and n is 0 or 1.Type: GrantFiled: July 13, 1979Date of Patent: March 24, 1981Assignee: Toyo Jozo Kabushiki KaishaInventors: Tadashiro Fujii, Nobuaki Nakagawa, Kikuo Kotani
-
Patent number: 4237267Abstract: A disulfide compound of a carrier, having S--S exchange reactivity, of the formulaR--S--S--X.sub.1 --X.sub.2 --A [I]wherein R is 2-benzothiazolyl, X.sub.1 is a spacer group directly bound to the --S--S-- and comprises a plurality of carbon atoms in a straight or branched chain, X.sub.2 is an imide or amide bonding group, and A is an insoluble carrier selected from the group consisting of beads gel agarose residue, gamma-aminopropylated nylon beads residue and a residual group of partially reduced polyacrylonitrile porous granules or fibers.Type: GrantFiled: April 30, 1979Date of Patent: December 2, 1980Assignee: Toyo Jozo Kabushiki KaishaInventors: Tsuneo Okuyama, Tadashiro Fujii, Nobuaki Nakagawa, Kikuo Kotani
-
Patent number: 4137406Abstract: Cephalosporins having a sulfur-containing functional group of the formula ##STR1## present at the carbon atom directly bonded to the thienyl or furyl group in the side chain of the 7-position of cephem derivatives. These compounds are useful as anti-bacterial agents against Gram-positive and Gram-negative bacteria.Type: GrantFiled: February 28, 1977Date of Patent: January 30, 1979Assignees: Sagami Chemical Research Center, Toyo Jozo Co., Ltd.Inventors: Genichi Tsuchihashi, Katsuyuki Ogura, Masao Yaso, Masashi Kuramoto, Tadashiro Fujii, Tetsuo Watanabe
-
Patent number: 3960662Abstract: 7-Amino-cephem compounds are produced from 7-substituted-cephem compounds by the enzymatic action of microorganisms Comamonas sp. SY-77-1 FERM-P 2410 or Pseudomonas ovalis ATCC 950.Type: GrantFiled: January 23, 1975Date of Patent: June 1, 1976Assignee: Toyo Jozo Kabushiki KaishaInventors: Tetsuo Matsuda, Tsutomu Yamaguchi, Tadashiro Fujii, Kunio Matsumoto, Masataka Morishita, Mitsuru Fukushima, Yuzo Shibuya
-
Patent number: 3935193Abstract: Novel diacyl penicillins of the formula ##EQU1## wherein R is alkyl, cycloalkyl, aryl, aralkyl, phenoxyalkyl, heterocyclic carboxyl excepting isoxazole carboxyl derivatives, or ##SPC1##In which benzene ring A may optionally be substituted andB represents a protective group for the amino group, and X is a protective group for the carboxyl group, are produced by reacting a benzyl penicillin ester of the formula ##EQU2## wherein X is as defined above, with a chlorinating agent in the presence of tertiary organic base to obtain an imide chloride group-incorporated compound of the formula ##EQU3## and then reacting the compound of the last-named formula with carboxylate of the formulaR-COOM (IV)wherein M is a metal atom, and R is as defined above.Type: GrantFiled: December 29, 1970Date of Patent: January 27, 1976Assignee: Toyo Jozo Kabushiki KaishaInventors: Jinnosuke Abe, Tetsuo Watanabe, Teruo Take, Kentaro Fujimoto, Tadashiro Fujii, Kazuyoshi Nishiie