Patents by Inventor Tadatoshi Hashimoto
Tadatoshi Hashimoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140155369Abstract: An agent for the prophylaxis or treatment of stress urinary incontinence, which contains a substance that activates a serotonin 5-HT2C receptor, an agent for the prophylaxis or treatment of stress urinary incontinence, which contains a substance that stimulates an androgen binding site, and a method of screening for a drug for the prophylaxis or treatment of abdominal pressure incontinence, which includes electrostimulating the abdominal muscles or a nerve controlling them of an animal to increase the abdominal pressure, and measuring the leak point pressure at that time.Type: ApplicationFiled: January 16, 2014Publication date: June 5, 2014Applicant: Takeda Pharmaceutical Company LimitedInventors: Izumi KAMO, Tadatoshi HASHIMOTO
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Patent number: 8470845Abstract: An analgesic which may be applied to wide variety of pain from various causes is disclosed.Type: GrantFiled: November 4, 2005Date of Patent: June 25, 2013Assignee: Toray Industries, Inc.Inventors: Naoki Izumimoto, Kuniaki Kawamura, Toshikazu Komagata, Tadatoshi Hashimoto, Hiroshi Nagabukuro
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Patent number: 7972800Abstract: By using a G protein-coupled receptor protein comprising an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and an ionizable metal element or a salt thereof, an agonist for or an antagonist to the above receptor protein or a salt thereof can be efficiently screened.Type: GrantFiled: April 23, 2009Date of Patent: July 5, 2011Assignee: Takeda Pharmaceutical Company LimitedInventors: Yasuaki Ito, Ryo Fujii, Makoto Kobayashi, Shuji Hinuma, Tadatoshi Hashimoto, Yasuhiro Tanaka
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Patent number: 7622487Abstract: The present invention provides a compound represented by the formula: wherein Ar is an aryl group, an aralkyl group or an aromatic heterocyclic group, each of which may be substituted, R1 is a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group or an optionally substituted heterocyclic group, X is an oxygen atom or an optionally substituted imino group, Z is an optionally substituted methylene group, Ring A is an optionally further substituted piperidine ring, and Ring B is an optionally substituted aromatic ring, provided that when Z is a methylene group substituted with an oxo group, R1 is not a methyl group, and when Z is a methylene group substituted with a methyl group, Ring B is a substituted aromatic ring, or a salt thereof, which is a novel piperidine derivative having excellent antagonistic action for a tachykinin receptor and useful as a medicament, particularly an agent for preventing and/or treating urinary frequency and/or urinary incontinence.Type: GrantFiled: May 29, 2003Date of Patent: November 24, 2009Assignee: Takeda Pharmaceutical Company LimitedInventors: Yoshinori Ikeura, Tadatoshi Hashimoto, Naoki Tarui, Junya Shirai
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Publication number: 20090227037Abstract: By using a G protein-coupled receptor protein comprising an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and an ionizable metal element or a salt thereof, an agonist for or an antagonist to the above receptor protein or a salt thereof can be efficiently screened.Type: ApplicationFiled: April 23, 2009Publication date: September 10, 2009Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Yasuaki ITO, Ryo Fuji, Makoto Kobayashi, Shuji Hinuma, Tadatoshi Hashimoto, Yasuhiro Tanaka
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Publication number: 20070299100Abstract: An analgesic which may be applied to wide variety of pain from various causes is disclosed.Type: ApplicationFiled: November 4, 2005Publication date: December 27, 2007Inventors: Naoki Izumimoto, Kuniaki Kawamura, Toshikazu Komagata, Tadatoshi Hashimoto, Hiroshi Nagabukuro
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Publication number: 20070274913Abstract: An agent for the prophylaxis or treatment of stress urinary incontinence, which contains a substance that activates a serotonin 5-HT2C receptor, an agent for the prophylaxis or treatment of stress urinary incontinence, which contains a substance that stimulates an androgen binding site, and a method of screening for a drug for the prophylaxis or treatment of abdominal pressure incontinence, which includes electrostimulating the abdominal muscles or a nerve controlling them of an animal to increase the abdominal pressure, and measuring the leak point pressure at that time.Type: ApplicationFiled: August 24, 2005Publication date: November 29, 2007Inventors: Izumi Kamo, Tadatoshi Hashimoto
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Publication number: 20060241145Abstract: The present invention provides a piperidine derivative having antagonistic action for tachykinin receptors and the like, a crystal thereof, and an agent for the prophylaxis or treatment of diseases including lower urinary tract disease and the like, which contains the derivative. Specifically, the present invention provides an optically active compound represented by the formula (I): wherein each symbol is as defined in the specification, and a salt thereof.Type: ApplicationFiled: April 20, 2006Publication date: October 26, 2006Inventors: Yoshinori Ikeura, Tadatoshi Hashimoto, Junya Shirai, Yoshikawa Takeshi, Hiroshi Nakatani, Mitsuhisa Yamano, Masahiro Mizuno, Hiroyuki Irie
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Publication number: 20060216286Abstract: By using a G protein-coupled receptor protein comprising an amino acid sequence, which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO: 1, or a salt thereof, and an ionizable metal element or a salt thereof, an agonist for or an antagonist to the above receptor protein or a salt thereof can be efficiently screened.Type: ApplicationFiled: April 23, 2004Publication date: September 28, 2006Inventors: Yasuaki Ito, Ryo Fujii, Makoto Kobayashi, Shuji Hinuma, Tadatoshi Hashimoto, Yasuhiro Tanaka
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Publication number: 20060167052Abstract: The present invention provides a compound represented by the formula: wherein Ar is an aryl group, an aralkyl group or an aromatic heterocyclic group, each of which may be substituted, R1 is a hydrogen atom, an optionally substituted hydrocarbon group, an acyl group or an optionally substituted heterocyclic group, X is an oxygen atom or an optionally lo substituted imino group, Z is an optionally substituted methylene group, Ring A is an optionally further substituted piperidine ring, and Ring B is an optionally substituted aromatic ring, provided that when Z is a methylene group substituted with an oxo group, R1 is not a methyl group, and 15 when Z is a methylene group substituted with a methyl group, Ring B is a substituted aromatic ring, or a salt thereof, which is a novel piperidine derivative having excellent antagonistic action for a tachykinin receptor and useful as a medicament, particularly an agent for preventing and/or treating urinary frequency and/or urinary incontinence.Type: ApplicationFiled: May 29, 2003Publication date: July 27, 2006Inventors: Yoshinori Ikeura, Tadatoshi Hashimoto, Naoki Tarui, Junya Shirai, Masayuki Yamashita
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Publication number: 20060142337Abstract: The present invention provides a compound represented by the formula: wherein Ar is an aryl group optionally having substituents, R is a C1-6 alkyl group, R1 is a hydrogen atom, a hydrocarbon group optionally having substituents, an acyl group or a heterocyclic group optionally having substituents, X is an oxygen atom or an imino group optionally having substituents, ring A is a piperidine ring optionally further having substituents, and ring B is a benzene ring having substituents, or a salt thereof, and an agent for the prophylaxis or treatment of lower urinary tract abnormality and the like, which contains the compound.Type: ApplicationFiled: February 22, 2006Publication date: June 29, 2006Inventors: Yoshinori Ikeura, Tadatoshi Hashimoto, Haruyuki Nishida, Junya Shirai, Nobuki Sakauchi
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Patent number: 7008940Abstract: A compound represented by the formula (I): or a salt thereof exhibits excellent inhibitory activity of lipid peroxidation and is useful as an agent for inhibiting lipoperoxide production, wherein ring A denotes a non-aromatic 5- to 7-membered nitrogen-containing heterocyclic ring which may be further substituted, B ring denotes a benzene ring which may be further substituted, C ring denotes a dihydrofuran ring which may be further substituted, and R denotes hydrogen atom or an acyl group.Type: GrantFiled: August 18, 2000Date of Patent: March 7, 2006Assignee: Takeda Pharmaceutical Company LimitedInventors: Shigenori Ohkawa, Tadatoshi Hashimoto, Tetsuya Tsukamoto
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Patent number: 6872718Abstract: A compound represented by the formula: wherein Ring A is a non-aromatic 5- to 7-membered nitrogen-containing heterocyclic ring which may be further substituted, Ring B is benzene ring which is further substituted, Ring C is a dihydrofuran-ring which may be further substituted and R is hydrogen atom or an acyl group or a salt thereof has an excellent lipid peroxidation inhibitory activity and is useful as a lipid peroxidation inhibitor.Type: GrantFiled: August 18, 2000Date of Patent: March 29, 2005Assignee: Takeda Chemical Industries, Ltd.Inventors: Shigenori Ohkawa, Tadatoshi Hashimoto, Tetsuya Tsukamoto
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Publication number: 20050038072Abstract: A novel compound represented by the formula (I): wherein rings A and B each represents an optionally substituted aromatic ring, or rings A and B may be bonded to each other through linking between bonds or substituents thereof to form a ring; ring C represents a nitrogenous saturated heterocycle optionally having one or more substituents besides the oxo (provided that 2,3-dioxopyrrolidine ring is excluded); R1 represents hydrogen, an optionally substituted hydrocarbon group, or an optionally substituted heterocyclic group; and indicates a single bond or a double bond. It has high antagonistic activity against a tachykinin receptor, especially an SP receptor.Type: ApplicationFiled: December 26, 2002Publication date: February 17, 2005Inventors: Masayoshi Yamaoka, Yoshinori Ikeura, Tadatoshi Hashimoto, Naoki Tarui
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Publication number: 20040058914Abstract: A pharmaceutical agent containing an NK-1 receptor antagonist, an NK-2 receptor antagonist and/or an anti-cholinergic drug in combination is provided, which is useful as a prophylactic or therapeutic agent of urinary frequency, urinary incontinence, asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, osteoarthritis, pain, cough, irritable bowel syndrome, emesis, depression, anxiety, manic depressive psychosis or schizophrenia.Type: ApplicationFiled: June 23, 2003Publication date: March 25, 2004Inventors: Takayuki Doi, Tadatoshi Hashimoto, Izumi Kamo
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Patent number: 6172085Abstract: A compound of the formula: wherein R1 and R2 each represents hydrogen, lower alkyl which may be substituted or acyl; R3, R4 and R5 each represents lower alkyl which may be substituted or lower alkoxy which may be substituted or R4 and R5 taken together represent a 5- or 6-membered carbocyclic group; R6 represents lower alkyl; Ar represents an aromatic group which may be substituted; ring A represents a 5- to 8-membered nitrogen-containing heterocyclic ring which may be substituted; X represents lower alkylene which may be substituted; Y represents carbon or nitrogen; Za represents CH2, COCH2, OCH2, SCH2, NHCH2, etc.; Zb represents a bond or a divalent aliphatic hydrocarbon group which may be substituted and may contain O, N or S; and m represents an integer of 1 to 3, or a salt thereof is useful for a pharmaceutical composition for modulating sodium channel.Type: GrantFiled: February 8, 1999Date of Patent: January 9, 2001Assignee: Takeda Chemical Industries, Ltd.Inventors: Shigenori Ohkawa, Tadatoshi Hashimoto, Kohji Fukatsu