Patents by Inventor Tadayoshi Ohmura
Tadayoshi Ohmura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5624687Abstract: The invention provides a solid preparation having a quick and pH-independent dissolution with an excellent bioavailability for a drug that is otherwise sharply depressed in solubility with pH elevation. This solid preparation contains granules each comprising a fine particulate core coated with a solid solution comprising a drug which is pH-dependent in solubility and may be released from an enteric base-containing composition at low pH and an enteric base.Type: GrantFiled: October 15, 1993Date of Patent: April 29, 1997Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Katsuhiko Yano, Yasuhiro Nishizono, Shigeru Yamazaki, Tadayoshi Ohmura, Shunji Hasumi
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Patent number: 5258186Abstract: A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material comprising, in a specific ratio, one specific water-insoluble and low water-permeability polymers and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer-materials).Type: GrantFiled: May 18, 1992Date of Patent: November 2, 1993Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Tadayoshi Ohmura, Muneo Fukui, Hiroshi Sugiura, Satoru Yoneya, Toshiharu Hosono, Atsushi Kajiyama
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Patent number: 5028664Abstract: A coating material for controlling drug release, useful for long acting formulations--e.g. for once-a-day administration, and to a long acting granular composition comprising a drug (especially one conventionally difficult to prepare in long acting form) coated with the coating material. This composition may be mixed with other granular drug formulations. The drug-release controlling coating material comprising, in a specific ration, one specific water-insoluble and low water-permeability polymers and two materials differing from each other in the pH-dependency of their solubility (pH-dependent polymer-materials).Type: GrantFiled: March 8, 1990Date of Patent: July 2, 1991Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Tadayoshi Ohmura, Muneo Fukui, Hiroshi Sugiura, Satoru Yoneya, Toshiharu Hosono, Atsushi Kajiyama
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Patent number: 4758437Abstract: A spherical pellet like composition of nicardipine composed of small granular nuclei such as sugar particles coated with amorphous nicardipine or a salt thereof, a pH-dependent additive and a surface active agent. The spherical pellet like composition of nicardipine may have a further coating of a medicament permeating material as an outermost coating. The spherical pellet like composition may be mixed with the spherical pellet like composition coated with the medicament permeating material.Type: GrantFiled: February 11, 1987Date of Patent: July 19, 1988Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Takashi Sonobe, Hiroitsu Kawata, Masayoshi Aruga, Tadayoshi Ohmura, Satoru Yoneya, Chiharu Yamada, Yukio Kubota
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Patent number: 4673564Abstract: Sustained release pharmaceutical compositions of a solid medical material which contains an amorphous solid medical material, polyethylene oxide, and at least one basic substance selected from the group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, methyl cellulose, polyvinyl pyrrolidone, carboxyvinyl polymer, hydroxypropylmethyl cellulose phthalate, cellulose acetate phthalate, methyl meta-acrylate meta-acrylic acid copolymer, polyvinylacetal diethylaminoacetate, dimethylaminoethyl meta-acrylate meta-acrylic acid copolymer, 2-methyl-5-vinylpyridinemethyl acrylate meta-acrylic acid copolymer, citric acid, urea, succinic acid and amino acid, and may further contain one basic substance selected from the group consisting of a surface active agent, polyethylene glycol, propylene glycol, glycerin, a glycerin fatty acid ester and a vegetable oil (first embodiment); and in the case where the solid medical material in nicardipine, the composition may consist only of the amorphous nicardipine oType: GrantFiled: October 23, 1985Date of Patent: June 16, 1987Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Hiroitsu Kawata, Masayoshi Aruga, Tadayoshi Ohmura, Takashi Sonobe, Satoru Yoneya, Chiharu Sone
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Patent number: 4578391Abstract: An oily composition of an antitumor drug comprising at least one sparingly oil soluble or water-soluble antitumor drug, at least one fat or oil, and at least one solubilizing adjuvant in an oily vehicle selected from the group consisting of crown ether, lecithin, polyethylene glycol, propylene glycol, vitamin E, polyoxyethylene alkylether, and sucrose esters of fatty acids.Type: GrantFiled: January 13, 1983Date of Patent: March 25, 1986Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Hiroitsu Kawata, Tadayoshi Ohmura, Shunji Hasumi, Yutaka Konno, Masayoshi Aruga, Seiki Tashiro, Toshimitsu Konno, Ken Iwai
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Patent number: 4412986Abstract: A novel nifedipine-containing solid pharmaceutical preparation composition comprising a mixture of nifedipine and at least one 1st(a) substance selected from polyvinyl pyrrolidone, methyl cellulose, hydroxypropyl cellulose and hydroxypropylmethyl cellulose; a mixture of nifedipine, at least one 1st(b) substance selected from polyvinyl pyrrolidone, urea, citric acid mannitol, succinic acid, methyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose and amino acid, and at least one 2nd substance selected from a surface active agent, polyethylene glycol, propylene glycol, glycerol, a glycerol fatty acid ester and a vegetable oil; or a mixture of nifedipine, the 1st(b) substance, the 2nd substance and calcium lactate.The composition of this invention can increase the bioavailability of nifedipine and makes it possible to provide a nifedipine-containing pharmaceutical preparation which has small bulk and can be easily administered.Type: GrantFiled: April 16, 1981Date of Patent: November 1, 1983Assignee: Yamanouchi Pharmaceutical Co. Ltd.Inventors: Hiroitsu Kawata, Tadayoshi Ohmura, Katsuhiko Yano, Mikio Matsumura, Saburo Higuchi, Yoshiaki Soeishi
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Patent number: 4404183Abstract: Sustained release pharmaceutical compositions of a solid medical material which contains an amorphous solid medical material, polyethylene oxide, and at least one basic substance selected from the group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, methyl cellulose, polyvinyl pyrrolidone, carboxyvinyl polymer, hydroxypropylmethyl cellulose phthalate, cellulose acetate phthalate, methyl meta-acrylate meta-acrylic acid copolymer, polyvinylacetal diethylaminoacetate, dimethylaminoethyl meta-acrylate meta-acrylic acid copolymer, 2-methyl-5-vinylpyridinemethyl acrylate meta-acrylic acid copolymer, citric acid, urea, succinic acid and amino acid, and may further contain one basic substance selected from the group consisting of a surface active agent, polyethylene glycol, propylene glycol, glycerin, a glycerin fatty acid ester and a vegetable oil (first embodiment); and in the case where the solid medical material is nicardipine, the composition may consist only of the amorphous nicardipine oType: GrantFiled: July 29, 1982Date of Patent: September 13, 1983Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Hiroitsu Kawata, Masayoshi Aruga, Tadayoshi Ohmura, Takashi Sonobe, Satoru Yoneya, Chiharu Sone
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Patent number: 4343789Abstract: Sustained release pharmaceutical composition of a solid medical material which contains an amorphous solid medical material, polyethylene oxide, and at least one basic substance selected from the group consisting of hydroxypropylmethyl cellulose, hydroxypropyl cellulose, methyl cellulose, polyvinyl pyrrolidone, carboxyvinyl polymer, hydroxypropylmethyl cellulose phthalate, cellulose acetate phthalate, methyl meta-acrylate meta-acrylic acid copolymer, polyvinylacetal diethylaminoacetate, dimethylaminoethyl meta-acrylate meta-acrylic acid copolymer, 2-methyl-5-vinylpyridinemethyl acrylate meta-acrylic acid copolymer, citric acid, urea, succinic acid and amino acid, and may further contain one basic substance selected from the group consisting of a surface active agent, polyethylene glycol, propylene glycol, glycerin, a glycerin fatty acid ester and a vegetable oil (first embodiment): and in the case where the solid medical material is nicardipine, the composition may consist only of the amorphous nicardipine orType: GrantFiled: July 2, 1980Date of Patent: August 10, 1982Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Hiroitsu Kawata, Masayoshi Aruga, Tadayoshi Ohmura, Takashi Sonobe, Satoru Yoneya, Chiharu Sone
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Patent number: 4258179Abstract: A novel coating agent for solid medicaments containing a hydrogel-like substance of a water-insoluble hydroxypropyl cellulose having 5-16% by weight of a hydroxypropoxy group or the dry powder of a hydrogel-like substance. By coating solid medicaments with the coating agent, solid medicaments having high impact resistance and showing very less aging can be provided advantageously in industry.Type: GrantFiled: December 20, 1978Date of Patent: March 24, 1981Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Hiroitsu Kawata, Tadayoshi Ohmura, Hiroyoshi Shiozawa, Munetaka Hattori
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Patent number: 4066787Abstract: A dried and stabilized prostaglandin composition containing a prostaglandin E group compound with calcium lactate and/or amylopectin, and a stabilized pharmaceutical preparation for practical administration prepared from the said composition.Type: GrantFiled: May 18, 1977Date of Patent: January 3, 1978Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Kiyoshi Okazaki, Hiroitsu Kawada, Hidemi Shimizu, Tadayoshi Ohmura, Jun Sekino
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Patent number: 4013773Abstract: A single phase solid composition wherein one part of a non-aqueous liquid and 0.5-6 parts of calcium lactate hydrate are mixed and heated. The product according to this invention is very stable and can be formed into various kinds of moldings by a simple operation so that it may be applied to many uses.Type: GrantFiled: February 4, 1975Date of Patent: March 22, 1977Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Masuo Murakami, Hiroitsu Kawada, Tadayoshi Ohmura, Hiroshi Sugiura