Patents by Inventor Tadayuki Kuraishi
Tadayuki Kuraishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5789419Abstract: This invention relates to a 4-quinolinone derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 and R.sup.2 mean individually H, halogen, cyano, or lower alkyl, lower alkylsulfonyl, lower alkylsulfinyl, lower alkylthio or lower alkoxy which may be substituted by halogen, or phenylsulfonyl, phenylsulfinyl or phenylthio which may have a substituent; and R.sup.3 and R.sup.4 denote individually H, lower alkyl or cycloalkyl which may be substituted by halogen, or pyridyl, furanyl or phenyl which may have a substituent, or R.sup.3 and R.sup.4 may form a 4-, 5- or 6-membered heterocyclic ring, or a salt thereof, and an intermediate useful for the preparation thereof, and besides a medicinal composition comprising this compound as an active ingredient. The compound (1) or the salt thereof has an excellent potassium channel-activating effect and is useful as, for example, a prophylactic and therapeutic agent for diseases of circulatory and bronchial systems.Type: GrantFiled: December 9, 1996Date of Patent: August 4, 1998Assignee: SS Pharmaceutical Co., Ltd.Inventors: Kazuo Yamazaki, Shigeru Adegawa, Yoichiro Ogawa, Hideaki Matsuda, Tadayuki Kuraishi
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Patent number: 5585511Abstract: A platinum complex represented by the following formula (1): ##STR1## wherein the all symbols are defined in the disclosure; and a malignant tumor treating drug which contains the complex as an active ingredient. The platinum complex is excellent in antitumor effects and safety and is highly soluble in water, and therefore it is useful as an agent for use in the treatment of various malignant tumors.Type: GrantFiled: December 26, 1995Date of Patent: December 17, 1996Assignee: SS Pharmaceutical Co., Ltd.Inventors: Koichi Yokoi, Kinichi Mogi, Hidehiko Kohya, Mari Ohtsuka, Hiroyuki Mizuno, Susumu Sato, Tadayuki Kuraishi
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Patent number: 5532371Abstract: An arylamide derivative of formula (1), a salt thereof and a therapeutic agent for hyperlipemia which comprises the derivative or salt: ##STR1## wherein Ar represents a group ##STR2## a naphthyl group, a pyridinyl group, a furyl group, a thienyl group, a quinolyl group or an indolyl group; Y represents a group ##STR3## and Q represents --O-- or a single bond, Z represents an alkylene group, and R.sup.4 represents a hydroxyl group, an alkoxy group or a group --NH(CH.sub.2).sub.m COOH.Type: GrantFiled: January 25, 1995Date of Patent: July 2, 1996Assignee: SS Pharmaceutical Co., Ltd.Inventors: Teruo Komoto, Hiroyuki Hirota, Susumu Sato, Mari Ohtsuka, Hidehiko Koya, Hiroyuki Mizuno, Tadayuki Kuraishi
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Patent number: 5498780Abstract: A diamine-platinum complex represented by the following formula (1): ##STR1## wherein the all definitions are defined in the disclosure, and a malignant tumor treating drug which contains the above complex as an active ingredient. The diamine-platinum complex has a high water solubility and an excellent antitumor effect.Type: GrantFiled: May 31, 1995Date of Patent: March 12, 1996Assignee: SS Pharmaceutical Co., Ltd.Inventors: Koichi Yokoi, Kinichi Mogi, Hidehiko Kohya, Mari Ohtsuka, Hiroyuki Mizuno, Susumu Sato, Tadayuki Kuraishi
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Patent number: 5440036Abstract: A 1,4-benzoxazine derivative represented by the following formula (1): ##STR1## wherein R.sup.1 represents an unsubstituted or halogen-substituted lower alkyl, unsubstituted or halogen-substituted lower alkylsulfonyl, nitro or cyano group, R.sup.2 and R.sup.3 may be the same or different and individually represent a hydrogen atom or a lower alkyl group or are fused together with the adjacent carbon atom into a 3- to 6-membered carbon ring, R.sup.4 represents a hydrogen atom or an unsubstituted or substituted lower alkyl or acyl group, R.sup.5 represents a hydrogen atom or a unsubstituted or substituted lower alkyl, lower alkenyl, lower alkoxyl, aryl, aryloxyl or heterocyclic ring group, and Y represents an oxygen or sulfur atom, with the proviso that R.sup.1 is other than a nitro or cyano group when R.sup.2 and R.sup.3 are individually a methyl group, R.sup.4 is a hydrogen atom, R.sup.5 is a 3-chloropropyl group and Y is an oxygen atom; or a salt thereof.Type: GrantFiled: December 3, 1993Date of Patent: August 8, 1995Assignee: SS Pharmaceutical Co., Ltd.Inventors: Kazuo Yamazaki, Shigeru Adegawa, Yoichiro Ogawa, Hideaki Matsuda, Tadayuki Kuraishi
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Patent number: 5430028Abstract: A 5-aminoquinolone carboxylic acid derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 means a hydrogen atom, an amino group, a linear or branched alkyl group having 1-5 carbon atoms and an alkylamino group containing a linear or branched alkyl group having 1-5 carbon atoms, R.sup.2 denotes a hydrogen atom or a linear or branched alkyl group having 1-5 carbon atoms, X stands for a halogen atom, Y means CH.sub.2, NH, CHR.sup.3 NR.sup.3, (R.sup.3 denoting a linear or branched alkyl group having 1-5 carbon atoms) or an oxygen atom, and Z stands for an oxygen atom or 2 hydrogen atoms, or a salt thereof, and an antibacterial agent containing such a derivative or salt as an active ingredient.The derivative or salt thereof exhibits strong anti-bacterial activities against Grampositive bacteria including tolerant bacteria, and is satisfactorily absorbed in a living body.Type: GrantFiled: January 26, 1994Date of Patent: July 4, 1995Assignee: SS Pharmaceutical Co., Ltd.Inventors: Terumitsu Kaihoh, Sunao Takeda, Fujiko Konno, Akihiro Shibata, Masaru Matsumoto, Takemitsu Asaoka, Hideaki Matsuda, Tadayuki Kuraishi
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Patent number: 5411972Abstract: An arylamide derivative of formula (1), a salt thereof and a therapeutic agent for hyperlipemia which comprises the derivative or salt: ##STR1## wherein Ar represents a group ##STR2## a naphthyl group, a pyridinyl group, a furyl group, a thienyl group, a quinolyl group or an indolyl group; Y represents a group ##STR3## and Q represents --O-- or a single bond, Z represents an alkylene group, and R.sup.4 represents a hydroxyl group, an alkoxy group or a group --NH(CH.sub.2).sub.m COOH, useful for the treatment and prevention of hyperlipemia due to their excellent cholesterol reducing action, triglyceride reducing action and high safety.Type: GrantFiled: November 29, 1993Date of Patent: May 2, 1995Assignee: SS Pharmaceutical Co., Ltd.Inventors: Teruo Komoto, Hiroyuki Hirota, Susumu Sato, Mari Ohtsuka, Hidehiko Koya, Hiroyuki Mizuno, Tadayuki Kuraishi
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Patent number: 5385900Abstract: A quinolone carboxylic acid derivative having the following formula (1), ##STR1## wherein R.sup.1 is a hydrogen atom, an alkyl group, an aralkyl group, an ester residual group which can be hydrolyzed in living bodies, R.sup.2 is a hydrogen atom or an amino group which may be substituted by one or two lower alkyl groups, X is a hydrogen atom or a halogen atom, Y is CH.sub.2, O, S, SO, SO.sub.2, or N--R.sup.3, wherein R.sup.3 is a hydrogen atom or a lower alkyl group, and Z is an oxygen atom or two hydrogen atoms; or a salt thereof; and an antimicrobial agent comprising the same. The compound exhibits a superior antimicrobial activity, especially against gram positive microorganisms, and is thus useful for the treatments and prevention of various infectious diseases in clinics.Type: GrantFiled: November 8, 1993Date of Patent: January 31, 1995Assignee: SS Pharmaceutical Co., Ltd.Inventors: Fujiko Konno, Akihiro Shibata, Hideaki Matsuda, Takemitsu Asaoka, Ryuichi Kawahara, Naokata Taido, Tadayuki Kuraishi, Sunao Takeda
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Patent number: 5324735Abstract: The present invention relates to a quinolone carboxylic acid derivative represented by the following the formula (I), ##STR1## wherein R.sub.1 is a lower alkyl group, R.sub.2 is a hydrogen atom or a lower alkyl group, R.sub.3 is a hydrogen atom or a halogen atom, R.sub.4 and R.sub.5 together form a five- or six-membered ring which may contain hetero atoms or may have substituents, provided that a compound wherein R.sub.1 is a methyl group, R.sub.2 and R.sub.3 are hydrogen atom and ##STR2## is a piperazinyl group is excluded; or a salt thereof; to an antimicrobial agent comprising the same as an effective component; and to an intermediate for producing same.Type: GrantFiled: January 17, 1992Date of Patent: June 28, 1994Assignee: SS Pharmaceutical Co., Ltd.Inventors: Akihiro Shibata, Hideaki Matsuda, Takemitsu Asaoka, Masaru Matsumoto, Ryuichi Kawahara, Tatsuhiko Katori, Naokata Taido, Tadayuki Kuraishi
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Patent number: 5300517Abstract: Piperidine compounds of formula II: ##STR1## that exhibit anticholinesterase activity and are effective in treating dementia.Type: GrantFiled: April 28, 1993Date of Patent: April 5, 1994Assignee: SS Pharmaceutical Co., Ltd.Inventors: Hiroshi Hasegawa, Kazuo Isomae, Takeshi Kotsugai, Noriaki Shioiri, Kumiko Sekine, Naokata Taido, Susumu Sato, Tadayuki Kuraishi
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Patent number: 5240934Abstract: Quinoline derivatives of the formula, ##STR1## wherein >A represents a group >N--(CH.sub.2).sub.n --, >C.dbd., >C.dbd.CH(CH.sub.2).sub.n --, or >CH(CH.sub.2).sub.n --, wherein n is an integer of 0-7; Y represents a group >C.dbd.O or >CHOH, R.sup.1 is a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group, R.sup.2 is a hydrogen atom, a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, a phenyl group which may have a substituent, a phenoxy group, an alkanoyloxy group, or an amino group which may have a substituent, R.sup.3 is a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group, and m is an integer of 1-3. The compounds and their salts exhibit a superior anti-acetylcholinesterase activity with no side effects and are effective for the prevention or cure of senile dementia or memory disturbance.Type: GrantFiled: September 18, 1992Date of Patent: August 31, 1993Assignee: SS Pharmaceutical Co., Ltd.Inventors: Hiroshi Hasegawa, Kazuo Isomae, Takeshi Kotsugai, Noriaki Shioiri, Kumiko Sekine, Naokata Taido, Susumu Sato, Tadayuki Kuraishi
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Patent number: 5231101Abstract: Benzo[5,6]cyclohepta[1,2-b]pyridine derivatives of the following formula: ##STR1## wherein R.sup.1 represents a cyano, carbamoyl, alkylsulfoxy, alkylsulfonyl, tetrazolyl or sulfonic acid group, and R.sup.2 represents a hydrogen atom, a cyano, phenyl, aralkyl, alkoxycarbonylalkyl, aminoalkylcarbamoylalkyl or lower alkyl group, or a group ##STR2## or --X--R.sub.4, X being an oxygen or sulfur atom, R.sup.3 standing for a hydrogen atom or a substituted or unsubstituted lower alkyl, phenyl or aralkyl group, and R.sup.4 being a substituted or unsubstituted lower alkyl, phenyl or aralkyl group or an aminoalkyl group, and salts thereof. Antiallergic and antihistamic agents containing one of the above derivatives or salts as an active ingredient are also described.Type: GrantFiled: January 17, 1992Date of Patent: July 27, 1993Assignee: SS Pharmaceutical Co., Ltd.Inventors: Haruyoshi Honda, Hiroyuki Mizuno, Kinichi Mogi, Yoshikuni Ito, Yasushi Kaneko, Naokata Taido, Susumu Sato, Tadayuki Kuraishi
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Patent number: 5190951Abstract: Quinoline derivatives of the formula, ##STR1## wherein > A represents a group >N--(CH.sub.2).sub.n --, >C.dbd., >C.dbd.CH(CH.sub.2).sub.n --, or >CH(CH.sub.2).sub.n --, wherein n is an integer of 0-7; Y represents a group >C.dbd.O or >CHOH, R.sup.1 is a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, or an alkylthio group, R.sup.2 is a hydrogen atom, a halogen atom, an alkyl group, a hydroxy group, an alkoxy group, a phenyl group which may have a substituent, a phenoxy group, an alkanoyloxy group, or an amino group which may have a substituent, R.sup.3 is a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group, and m is an integer of 1-3. The compounds and their salts exhibit a superior antiacetylcholinesterase activity with no side effects and are effective for the prevention or cure of senile dementia or memory disturbance.Type: GrantFiled: October 9, 1991Date of Patent: March 2, 1993Assignee: SS Pharmaceutical Co., Ltd.Inventors: Hiroshi Hasegawa, Kazuo Isomae, Takeshi Kotsugai, Noriaki Shioiri, Kumiko Sekine, Naokata Taido, Susumu Sato, Tadayuki Kuraishi
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Patent number: 5159091Abstract: A process for preparing 21-desoxyprednisolone 17-esters of formula (IV) is disclosed. ##STR1## The process comprises reacting a prednisolone 17.alpha.,21-cyclic orthoester with an acid in a 40-60% lower alcohol solution to produce a prednisolone 17-ester, sulfonylating the prednisolone 17-ester into a prednisolone 17-ester 21-sulfonate, and reacting the sulfonate with an alkali metal iodide in methyl ethyl ketone in the presence of a lower fatty acid to produce the compound of formula (IV). The process ensures economical industrial production of high purity 21-desoxyprednisolone 17-esters, an excellent local anti-inflammatory medicine, in a high yield by simple procedures.Type: GrantFiled: October 12, 1990Date of Patent: October 27, 1992Assignee: SS Pharmaceutical Co., Ltd.Inventors: Tadatoshi Kuriyama, Masaki Ogawa, Susumu Sato, Naokata Taido, Tadayuki Kuraishi
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Patent number: 5147886Abstract: A triazole derivative is disclosed. The compound have a general formula, ##STR1## wherein R.sup.1 and R.sup.2 represent a hydrogen atom or a lower alkyl group, or R.sup.1 and R.sup.2 together form a lower alkylene group, R.sup.3 represents a lower alkyl group, and n denotes an integer of 0 to 2, provided that not both R.sup.1 and R.sup.2 are a hydrogen atom at the same time. The triazole derivatives and their salts are effective for curing or preventing deep-seated mycoses, e.g. mycotic meningitis, mycotic infectious diseases of respiratory organs, fungemia, and urinary tract mycosis.Type: GrantFiled: December 12, 1990Date of Patent: September 15, 1992Assignee: SS Pharmaceutical Co., Ltd.Inventors: Minoru Tokizawa, Yoshihiko Kanamaru, Masaru Matsumoto, Takemitsu Asaoka, Hideaki Matsuda, Tadayuki Kuraishi, Kazunori Maebashi, Naokata Taido, Ryuichi Kawahara
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Patent number: 5063222Abstract: Steroid derivatives represented by formula (I) are disclosed. ##STR1## wherein R is a hydrogen atom, a halogen atom, a hydroxy group, or a group --OCOR.sub.1, wherein R.sub.1 is a linear or branched alkyl group which may be substituted by a halogen atom or a cycloalkyl group, a cycloalkyl group, or an aryl group. The compounds are useful for curing or alleviating inflammation or rheumatism.Type: GrantFiled: April 13, 1990Date of Patent: November 5, 1991Assignee: SS Pharmaceutical Co., Ltd.Inventors: Teruo Komoto, Junji Okawa, Yoichiro Ogawa, Susumu Sato, Naokata Taido, Tadayuki Kuraishi
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Patent number: 4987144Abstract: Disclosed herein is 1,3-bis(1,2,4-triazol-1-yl)-2-(4-trifluoromethylphenyl)propan-2-ol represented by the following formula (I): ##STR1## An antimycotic preparation containing the triazole compound (I) is also disclosed. Also disclosed is a method for the prevention and/treatment of a deep-seated mycosis of a human or mammal, which comprises administering an effective dose of the triazole compound (I) to the human or mammal.Type: GrantFiled: September 25, 1989Date of Patent: January 22, 1991Assignee: SS Pharmaceutical Co., Ltd.Inventors: Yoshihiko Kanamaru, Minoru Tokizawa, Masaru Matsumoto, Takemitsu Asaoka, Hideaki Matsuda, Tadayuki Kuraishi
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Patent number: 4690924Abstract: Certain 1,7-naphthyridine derivatives and their acid addition salts have strong anticholinergic effects, cardiotonic effects, diuretic effects, bronchodilation effects, anti-acetylocholine effects, anti-inflammatory effects, analgesic effects and the like and are hence useful for various diseases such as heart diseases, hypertension, asthma, arthritis, lumbago, toothache, etc.Type: GrantFiled: December 9, 1986Date of Patent: September 1, 1987Assignee: SS Pharmaceutical Co., Ltd.Inventors: Susumu Sato, Haruyoshi Honda, Teruo Koumoto, Kazuo Isomae, Tadayuki Kuraishi, Tatsuhiko Katori
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Patent number: 4659710Abstract: Certain 1,7-naphthyridine derivatives and their acid addition salts have strong antiarrhythmic effects, cardiotonic effects, diuretic effects, bronchodilation effects, anti-acetylcholine effects, anti-inflammatory effects, analgesic effects and the like and are hence useful for various diseases such as heart diseases, hypertension, asthma, arthritis, lumbago, toothache, etc.Type: GrantFiled: April 11, 1986Date of Patent: April 21, 1987Assignee: SS Pharmaceutical Co., Ltd.Inventors: Susumu Sato, Haruyoshi Honda, Teruo Koumoto, Kazuo Isomae, Tadayuki Kuraishi, Tatsuhiko Katori
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Patent number: 4450109Abstract: The specification describes novel thiazinobenzimidazole derivatives represented by the general formula: ##STR1## wherein R.sub.1, R.sub.2 and X represent a wide variety of substituent groups respectively. The above thiazinobenzimidazole derivatives may be prepared by reacting corresponding 2-hydroxymethyl thiazinobenzimidazole derivatives with corresponding reactive derivatives of carboxylic acid or halogenide or by reacting 2-p-toluenesulfonyloxymethyl-thiazinobenzimidazole derivatives with sodium azides, thiols, phenols or amines. The above thiazinobenzimidazole derivatives wherein X is OH may be prepared by reducing their corresponding 2-alkoxycarbonyl derivatives. Where X represents a p-toluenesulfonyloxy group, the thiazinobenzimidazole derivatives may be obtained by reacting corresponding 2-hydroxymethyl-thiazinobenzimidazole derivatives with p-toluenesulfonyl chloride.Type: GrantFiled: September 13, 1982Date of Patent: May 22, 1984Assignee: SS Pharmaceutical Co., Ltd.Inventors: Hiromichi Eto, Teruo Kohmoto, Tadayuki Kouda, Youichiro Ogawa, Susumu Sato, Tadayuki Kuraishi, Toshiaki Nakashima