Abstract: The present disclosure relates to a device for determining a biomarker concentration in a blood of a body part under consideration of the physiological constitution of the body part. The device comprises a light source for radiating first light waves to the body part, a detector unit for measuring the reflected first light waves reflected from the body part and a processing unit coupled to the detector unit for receiving the measured first light waves.

Abstract: The subject of the invention is a membrane for separation of target stem cells from biological samples, more precisely from a single-cell suspension that was prepared from a biological sample. As a result, sterile target stem cells are obtained in physiological buffer. The membrane of the invention consists of a 3D carrier structure made of at least one layer of biocompatible polymer with specific pore size, as a carrier material, and covalently bound target molecules on its surface and/or in the pores. These target molecules are preferably target antibodies, which recognize characteristic antigens that are bound on the surface of the target stem cells and thus bind the target stem cells to the membrane. Target molecules can be either directly bound to the surface and/or in the pores of the carrier structure or are bound to the surface and/or in the pores of the carrier structure through specific functionalized nanoparticles, which are bound to or embedded into the 3D carrier structure of the membrane.

Abstract: The object of the invention is a device that allows measuring blood sugar levels in mammals—primarily humans—by measuring the refraction of electromagnetic radiation from the skin or body tissue, without the need for invasive sampling, such as penetrating or pricking the skin. The device uses the blue light portion of the visible spectrum and near-infrared (IR) radiation as a source of electromagnetic radiation. The device falls within the field of medical diagnostics and is essentially designed to be portable, so that the users can wear it on their wrists, for example. The signals of reflected light/radiation measured by the sensor unit are filtered by the frequency filtering set and mathematically processed in order to Calculate the current blood sugar level. The accuracy of the measurement result of the device is comparable to the results obtained with the standard method of measuring by blood sampling. A method for measuring of blood sugar level using said device is also disclosed.

Abstract: The object of the invention is a device that allows measuring blood sugar levels in mammals—primarily humans—by measuring the refraction of electromagnetic radiation from the skin or body tissue, without the need for invasive sampling, such as penetrating or pricking the skin. The device uses the blue light portion of the visible spectrum and near-infrared (IR) radiation as a source of electromagnetic radiation. The device falls within the field of medical diagnostics and is essentially designed to be portable, so that the users can wear it on their wrists, for example. The signals of reflected light/radiation measured by the sensor unit are filtered by the frequency filtering set and mathematically processed in order to Calculate the current blood sugar level. The accuracy of the measurement result of the device is comparable to the results obtained with the standard method of measuring by blood sampling. A method for measuring of blood sugar level using said device is also disclosed.