Patents by Inventor Tadeusz Cynkowski
Tadeusz Cynkowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110183944Abstract: Compositions for controlled release of one or more therapeutic agents where the composition is essentially free of excipients are disclosed. In particular, compositions comprising a HMG-CoA reductase inhibitor, particularly simvastatin, and a NSAID, such as a COX-2 inhibitor, particularly celecoxib, in which greater than 90% of the weight of the composition is made up of the HMG-CoA reductase inhibitor and NSAID are provided.Type: ApplicationFiled: January 27, 2011Publication date: July 28, 2011Inventors: Paul Ashton, Hong Guo, Jianbing Chen, Tadeusz Cynkowski, Grazyna Cynkowska
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Publication number: 20090163457Abstract: The invention relates to codrugs having improved properties, methods for preparing and administering them, and methods of formulating and administering the codrugs as pharmaceutical preparations. In certain embodiments, the codrugs can be locally administered to deliver the constituent biologically active compound in a sustained-release fashion, reducing systemic concentrations of the biologically active compound.Type: ApplicationFiled: November 26, 2008Publication date: June 25, 2009Applicant: pSivida, Inc.Inventors: Paul Ashton, Jianbing Chen, Hong Guo, Grazyna Cynkowska, Tadeusz Cynkowski
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Publication number: 20080107720Abstract: The present invention provides pharmaceutical compositions for topical delivery comprising a suitable carrier and a codrug capable of penetrating, or being transported across, the dermis. The codrug according to the invention comprises a first constituent moiety linked to a second constituent moiety, wherein the second constituent moiety is the same as, or different from, the first constituent moiety. The first and second constituent moieties are so linked that they are easily transported into or across the dermis, into the skin, or into the blood or lymphatic system, and are reconstituted in vivo to form the first and second constituent moieties.Type: ApplicationFiled: January 4, 2008Publication date: May 8, 2008Applicant: pSivida, Inc.Inventors: Kenneth Walters, Robert Shimizu, Paul Ashton, Grazyna Cynkowska, Tadeusz Cynkowski, Eric Gauthier
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Publication number: 20070213390Abstract: A compound that contains at least two independently active pharmacological moieties, either covalently conjoined through a physiologically labile linker or ionically associated. One pharmacological moiety is an HMGCoA reductase inhibitor (such as a statin). Another pharmacological moiety is an angiotensin converting enzyme inhibitor.Type: ApplicationFiled: March 14, 2007Publication date: September 13, 2007Applicant: pSivida Inc.Inventors: Tadeusz Cynkowski, Grazyna Cynkowska, Thomas Smith
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Publication number: 20070112050Abstract: The invention provides a compound comprising a first pharmacological moiety connected to at least a second pharmacological moiety through a physiologically labile linker, or a salt thereof. The invention also provides a method of reducing cardiovascular disease or cardiovascular disease-related conditions in an individual. The method involves administering to an individual with cardiovascular disease an effective amount of a compound, in which the compound has a first pharmacological moiety linked to a second pharmacological moiety, and the compound or either or both of the constituent pharmacological moieties acts to reduce, treat, or prevent cardiovascular disease. The compounds of the invention can be delivered in a drug delivery device.Type: ApplicationFiled: April 12, 2006Publication date: May 17, 2007Applicant: pSivida Inc.Inventors: Paul Ashton, Grazyna Cynkowska, Tadeusz Cynkowski, Thomas Smith
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Patent number: 7214710Abstract: The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof.Type: GrantFiled: May 24, 2004Date of Patent: May 8, 2007Assignee: University of Kentucky Research FoundationInventors: Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, Paul Ashton
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Publication number: 20070082041Abstract: The present invention provides pharmaceutical compositions for topical delivery comprising a suitable carrier and a codrug capable of penetrating, or being transported across, the dermis. The codrug according to the invention comprises a first constituent moiety linked to a second constituent moiety, wherein the second constituent moiety is the same as, or different from, the first constituent moiety. The first and second constituent moieties are so linked that they are easily transported into or across the dermis, into the skin, or into the blood or lymphatic system, and are reconstituted in vivo to form the first and second constituent moieties.Type: ApplicationFiled: December 11, 2006Publication date: April 12, 2007Applicant: pSivida Inc.Inventors: Kenneth Walters, Robert Shimizu, Paul Ashton, Grazyna Cynkowska, Tadeusz Cynkowski, Eric Gauthier
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Publication number: 20050164994Abstract: Genitourinary system disorders are treated with therapeutic agents, and optionally further with radiation treatments.Type: ApplicationFiled: June 3, 2004Publication date: July 28, 2005Applicant: Control Deliver Systems, Inc.Inventors: Paul Ashton, Grazyna Cynkowska, Tadeusz Cynkowski, Thomas Smith
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Publication number: 20050008695Abstract: The invention relates to codrugs having improved properties, methods for preparing and administering them, and methods of formulating and administering the codrugs as pharmaceutical preparations. In certain embodiments, the codrugs can be locally administered to deliver the constituent biologically active compound in a sustained-release fashion, reducing systemic concentrations of the biologically active compound.Type: ApplicationFiled: May 21, 2004Publication date: January 13, 2005Applicant: Control Delivery Systems, Inc.Inventors: Paul Ashton, Jianbing Chen, Hong Guo, Grazyna Cynkowska, Tadeusz Cynkowski
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Publication number: 20040214784Abstract: The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof.Type: ApplicationFiled: May 24, 2004Publication date: October 28, 2004Applicant: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATIONInventors: Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, Paul Ashton
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Publication number: 20040180036Abstract: A salt of a codrug of at least two drug compounds covalently linked to one another via a labile bond to form a single codrug, and methods of use of the codrug salt for the treatment of various medical conditions. The codrug salt may be administered by itself or in the form of a bioerodible or nonbioerodible substance.Type: ApplicationFiled: January 21, 2004Publication date: September 16, 2004Applicant: Control Delivery Systems, Inc.Inventors: Paul Ashton, Tadeusz Cynkowski, Grazyna Cynkowska
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Patent number: 6765019Abstract: The present invention relates to the field of prodrugs of chemotherapeutic agents and method of use thereof.Type: GrantFiled: May 4, 2000Date of Patent: July 20, 2004Assignee: University of Kentucky Research FoundationInventors: Peter A. Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hong Guo, Paul Ashton
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Publication number: 20030170286Abstract: Genitourinary system disorders are treated with therapeutic agents, and optionally further with radiation treatments.Type: ApplicationFiled: December 10, 2002Publication date: September 11, 2003Inventors: Paul Ashton, Grazyna Cynkowska, Tadeusz Cynkowski, Thomas J. Smith
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Publication number: 20030118528Abstract: The present invention provides pharmaceutical compositions for topical delivery comprising a suitable carrier and a codrug capable of penetrating, or being transported across, the dermis. The codrug according to the invention comprises a first constituent moiety linked to a second constituent moiety, wherein the second constituent moiety is the same as, or different from, the first constituent moiety. The first and second constituent moieties are so linked that they are easily transported into or across the dermis, into the skin, or into the blood or lymphatic system, and are reconstituted in vivo to form the first and second constituent moieties.Type: ApplicationFiled: November 19, 2002Publication date: June 26, 2003Inventors: Kenneth A. Walters, Robert Shimizu, Paul Ashton, Grazyna Cynkowska, Tadeusz Cynkowski, Eric Gauthier
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Publication number: 20030022876Abstract: A pharmaceutically active inventive compound comprises two independently active analgesic moieties covalently conjoined through a physiologically labile linker. A preferred embodiment comprises an opioid, such as morphine, covalently linked to at least one analgesic compound selected from the group consisting of an opioid or a non-opioid compound through a physiologically labile linker. Suitable covalent linkers are covalently bonded to the two independently active analgesic compounds through one or more lactone, lactam, or sulfonamido linkages. Suitable linkers include endogenous carboxylate, amido, and sulfonamido moieties, and exogenous moieties that form the aforementioned lactone, lactam or sulfonamido linkages.Type: ApplicationFiled: June 5, 2002Publication date: January 30, 2003Inventors: Paul A. Ashton, Thomas J. Smith, Tadeusz Cynkowski, Grazyna Cynkowska, Edmund Mickunas
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Patent number: 6051576Abstract: A codrug composition of at least two drug compounds covalently linked to one another via a labile bond to form a single codrug composition, or ionically linked to one another to form a single workings composition, and methods of use of the codrug for the treatment of various medical conditions. The codrug may be administered by itself or in the form of a bioerodible or nonbioerodible substance.Type: GrantFiled: January 29, 1997Date of Patent: April 18, 2000Assignee: University Of Kentucky Research FoundationInventors: Paul Ashton, Peter Anthony Crooks, Tadeusz Cynkowski, Grazyna Cynkowska, Hone Guo
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Patent number: 5681964Abstract: Prodrugs containing an active drug molecule linked to a polyethylene glycol group, and a method of use thereof are described. Exemplary soluble ester prodrugs contain naproxen, triamcinolone acetonide, gancyclovir, taxol, cyclosporin, dideoxyinosine, trihydroxy steroids, and flurbiprofen molecules linked to polyethylene glycol (PEG) groups. Pharmaceutical compositions containing these prodrugs, and a method of using these esters for treating disease states or symptoms are also described.Type: GrantFiled: October 5, 1994Date of Patent: October 28, 1997Assignee: University of Kentucky Research FoundationInventors: Paul Ashton, Thomas J. Smith, Peter G. Glavinos, John D. Conklin, Jr., Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska