Patents by Inventor Tadeusz F. Molinski

Tadeusz F. Molinski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hemi-phorboxazole A derivatives and methods of their use
    Patent number: 8957097
    Abstract: The present invention is directed to hemi phorboxazole A: and its stereoisomers, as well as derivatives of hemi phorboxazole A of formula I: wherein ring A is aryl or a 5- or 6-membered heteroaryl optionally substituted with one or more of halogen, —OH, or —C1-6alkyl; and R is —CN, a 5- or 6-membered heteroaryl, or halogen; and the pharmaceutically acceptable salt forms thereof, in addition to methods of using these compounds.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: February 17, 2015
    Assignees: The Trustees Of The University Of Pennsylvania, The Regents Of The University Of California
    Inventors: Amos B. Smith, III, Zhuqing Liu, Anne-Marie L. Hogan, Doralyn S. Dalisay, Tadeusz F. Molinski
  • HEMI-PHORBOXAZOLE A DERIVATIVES AND METHODS OF THEIR USE
    Publication number: 20130030027
    Abstract: The present invention is directed to hemi phorboxazole A: and its stereoisomers, as well as derivatives of hemi phorboxazole A of formula I: wherein ring A is aryl or a 5- or 6-membered heteroaryl optionally substituted with one or more of halogen, —OH, or —C1-6alkyl; and R is —CN, a 5- or 6-membered heteroaryl, or halogen; and the pharmaceutically acceptable salt forms thereof, in addition to methods of using these compounds.
    Type: Application
    Filed: July 23, 2010
    Publication date: January 31, 2013
    Applicants: The Regents of the University of California, The Trustes of The University of Pennsylvania
    Inventors: Amos B. Smith, III, Zhuqing Liu, Anne-Marie L. Hogan, Doralyn S. Dalisay, Tadeusz F. Molinski
  • Wnt signaling inhibitors, and methods for making and using them
    Patent number: 8304408
    Abstract: The invention provides dBHD-based compositions and dBHD analog compositions, and pharmaceutical compositions comprising them, e.g., in the form of liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these dBHD analogs are used to inhibit a dysfunctional stem cell and/or a cancer (tumor) stem cell.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: November 6, 2012
    Assignee: The Regents of the University of California
    Inventors: Wolfgang Wrasidlo, Catriona H. Jamieson, Dennis Carson, Tadeusz F. Molinski, Desheng Lu
  • WNT SIGNALLING INHIBITORS, AND METHODS FOR MAKING AND USING THEM
    Publication number: 20100203113
    Abstract: The invention provides dBHD-based compositions and dBHD analog compositions, and pharmaceutical compositions comprising them, e.g., in the form of liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment, these dBHD analogs are used to inhibit a dysfunctional stem cell and/or a cancer (tumor) stem cell.
    Type: Application
    Filed: May 15, 2008
    Publication date: August 12, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Wolfgang Wrasidlo, Catriona H. Jamieson, Dennis Carson, Tadeusz F. Molinski, Desheng Lu
  • Ion exchange resins
    Patent number: 4385130
    Abstract: A cation exchange resin, suitable for use as a membrane in electrolysis cells, comprising a perhalogenated fluorine containing hydrocarbon polymeric substrate with pendant active side chains containing dicarboxylic acid groups or their derivatives, and method of preparation thereof.
    Type: Grant
    Filed: December 15, 1980
    Date of Patent: May 24, 1983
    Assignee: ICI Australia Limited
    Inventors: Tadeusz F. Molinski, Michael V. Markus