Patents by Inventor Tadeusz J. Kochel

Tadeusz J. Kochel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PSORALEN-INACTIVATED DENGUE VIRUS VACCINE AND METHOD OF PREPARATION
    Publication number: 20150291936
    Abstract: A method to inactivate virus for vaccine uses by exposing said virus to a predetermined concentration of an inactivating psoralen, and exposing said virus to a preselected intensity of ultraviolet radiation for a time period sufficiently long to render the virus non-infectious but less than that which would result in degradation of its antigenic characteristics.
    Type: Application
    Filed: March 9, 2015
    Publication date: October 15, 2015
    Applicant: The United States of American as Represented by the Secretary of the Navy
    Inventors: Tadeusz J. Kochel, Porter Kavin, Ryan C. Maves
  • Psoralen-inactivated viral vaccine and method of preparation
    Patent number: 9005633
    Abstract: A method to prepare inactivate viral vaccine by exposing the virus to a predetermined concentration of an inactivating psoralen, and a preselected intensity of ultraviolet radiation for a time period sufficiently long to render the virus non-infectious but less than that which would result in degradation of its antigenic characteristics.
    Type: Grant
    Filed: July 17, 2010
    Date of Patent: April 14, 2015
    Assignee: The United States of America as Represented by the Secretary of the Navy.
    Inventors: Tadeusz J. Kochel, Ryan C. Maves, Kevin Porter
  • PSORALEN-INACTIVATED VIRAL VACCINE AND METHOD OF PREPARATION
    Publication number: 20110014233
    Abstract: A method to prepare inactivate viral vaccine by exposing the virus to a predetermined concentration of an inactivating psoralen, and a preselected intensity of ultraviolet radiation for a time period sufficiently long to render the virus non-infectious but less than that which would result in degradation of its antigenic characteristics.
    Type: Application
    Filed: July 17, 2010
    Publication date: January 20, 2011
    Inventors: Tadeusz J. Kochel, Ryan C. Maves, Kevin Porter
  • Dengue nucleic acid vaccines that induce neutralizing antibodies
    Patent number: 6455509
    Abstract: A vaccine for promoting an immune response in a mammalian subject includes a eucaryotic plasmid expression vector which include at least part of the envelope gene and optionally, the PreM gene of dengue virus. In order to minimize immune enhancement, vaccines of up to the four serotypes of dengue are combined in a single vaccine. The vaccine in a suitable pharmaceutical carrier constitutes a pharmaceutical composition which is injected into the subject.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: September 24, 2002
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Tadeusz J. Kochel, Kevin R. Porter, Kanakatte Raviprakash, Stephen L. Hoffman, Curtis G. Hayes