Patents by Inventor Tadeusz Krzysztof Wyrzykiewicz

Tadeusz Krzysztof Wyrzykiewicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR OPTIMIZING CLEAVAGE OF RNA BY RNASE H
    Publication number: 20150011001
    Abstract: The present invention provides compositions and methods for the optimization of cleavage of RNA species by RNase H. In some embodiments, the invention provides oligonucleotides that possess two or more regions of differing conformation, and at least one transitional nucleobase positioned between the regions that is capable of modulating transfer of the helical conformation characteristic of the region bound to the 3? hydroxy thereof, to the region bound to the 5? hydroxyl thereof.
    Type: Application
    Filed: June 13, 2014
    Publication date: January 8, 2015
    Applicant: ISIS PHARMACEUTICALS, INC.
    Inventors: Michael T. Migawa, Walter F. Lima, Eric E. Swayze, Joshua Nichols, Hongjiang Wu, Thazha P. Prakash, Tadeusz Krzysztof Wyrzykiewicz, Balkrishen Bhat, Stanley T. Crooke
  • Compositions and methods for optimizing cleavage of RNA by RNase H
    Patent number: 8790919
    Abstract: The present invention provides compositions and methods for the optimization of cleavage of RNA species by RNase H. In some embodiments, the invention provides oligonucleotides that possess two or more regions of differing conformation, and at least one transitional nucleobase positioned between the regions that is capable of modulating transfer of the helical conformation characteristic of the region bound to the 3?hydroxy thereof, to the region bound to the 5? hydroxyl thereof.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: July 29, 2014
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Michael T. Migawa, Walter F. Lima, Eric E. Swayze, Joshua Nichols, Hongjiang Wu, Thazha P. Prakash, Tadeusz Krzysztof Wyrzykiewicz, Balkrishen Bhat, Stanley T. Crooke
  • Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
    Patent number: 8703728
    Abstract: The present invention relates to bicyclic nucleosides and oligomeric compounds comprising at least one such nucleoside. These oligomeric compounds typically have enhanced binding affinity and nuclease resistance properties compared to unmodified oligomeric compounds. The oligomeric compounds are useful, for example, for investigative and therapeutic purposes.
    Type: Grant
    Filed: September 8, 2004
    Date of Patent: April 22, 2014
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Eric E. Swayze, Michael T. Migawa, Tadeusz Krzysztof Wyrzykiewicz
  • Process for the manufacture of oligonucleotides
    Patent number: 8513404
    Abstract: A process for manufacturing an oligonucleotide which comprises removing ?-eliminating phosphorus-protecting groups, in particular ?-cyanoethyl protective groups from a protected oligonucleotide, wherein said removing comprises contacting the protected oligonucleotide with an amine solution in a solvent which preferably does not consist of pyridine, wherein the conjugate acid of the amine has preferably a pKa of greater than 11.5, and wherein the concentration of the amine in the solution is less than 0.5 mole/liters.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: August 20, 2013
    Assignee: Nitto Denko Avecia, Inc.
    Inventors: Tadeusz Krzysztof Wyrzykiewicz, Hagen Cramer, Huihe Zhu, Kevin James Finn
  • Process for the manufacture of oligonucleotides
    Publication number: 20110087014
    Abstract: A process for manufacturing an oligonucleotide which comprises removing ?-eliminating phosphorus-protecting groups, in particular ?-cyanoethyl protective groups from a protected oligonucleotide, wherein said removing comprises contacting the protected oligonucleotide with an amine solution in a solvent which preferably does not consist of pyridine, wherein the conjugate acid of the amine has preferably a pKa of greater than 11.5, and wherein the concentration of the amine in the solution is less than 0.5 mole/liters.
    Type: Application
    Filed: April 24, 2009
    Publication date: April 14, 2011
    Applicant: GIRINDUS AMERICA, INC.
    Inventors: Tadeusz Krzysztof Wyrzykiewicz, Hagen Cramer, Huihe Zhu, Kevin James Finn
  • Compositions and Methods For Optimizing Cleavage of Rna By Rnase H
    Publication number: 20080207541
    Abstract: The present invention provides compositions and methods for the optimization of cleavage of RNA species by RNase H. In some embodiments, the invention provides oligonucleotides that possess two or more regions of differing conformation, and at least one transitional nucleobase positioned between the regions that is capable of modulating transfer of the helical conformation characteristic of the region bound to the 3?hydroxy thereof, to the region bound to the 5? hydroxyl thereof.
    Type: Application
    Filed: March 15, 2005
    Publication date: August 28, 2008
    Inventors: Michael T. Migawa, Walter F. Lima, Eric E. Swayze, Joshua Nichols, Hongjiang Wu, Thazha P. Prakash, Tadeusz Krzysztof Wyrzykiewicz, Balkrishen Bhat, Stanley T. Crooke