Patents by Inventor Tadeusz Warchol

Tadeusz Warchol has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE FORMS OF OMADACYCLINE, METHODS OF SYNTHESIS THEREOF AND METHODS OF USE THEREOF
    Publication number: 20230357135
    Abstract: The present invention provides omadacycline crystalline freebase and methods of synthesis thereof. The present invention also provides pharmaceutical compositions comprising omadacycline crystalline freebase and methods of use thereof for treating bacterial infections. The present invention also provides methods of purifying crude omadacycline freebase that comprise crystallization to produce crystalline omadacycline freebase. The omadacycline crystalline freebase may also be used to prepare salts of omadacycline, e.g., a tosylate salt.
    Type: Application
    Filed: June 11, 2021
    Publication date: November 9, 2023
    Inventors: Tadeusz Warchol, Sean M. Johnston
  • SALTS AND POLYMORPHS OF A TETRACYCLINE COMPOUND
    Publication number: 20180104262
    Abstract: Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general.
    Type: Application
    Filed: September 21, 2017
    Publication date: April 19, 2018
    Inventors: Raymond Cvetovich, Tadeusz Warchol
  • METHODS FOR SYNTHESIZING SUBSTITUTED TETRACYCLINE COMPOUNDS
    Publication number: 20170283368
    Abstract: Methods of synthesizing substituted tetracycline compounds are provided.
    Type: Application
    Filed: November 15, 2016
    Publication date: October 5, 2017
    Inventors: Farzaneh Seyedi, Tadeusz Warchol, Mark Grier
  • METHODS FOR SYNTHESIZING AND PURIFYING AMINOALKYL TETRACYCLINE COMPOUNDS
    Publication number: 20170158616
    Abstract: Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
    Type: Application
    Filed: July 13, 2016
    Publication date: June 8, 2017
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Sean M. Johnston, Tadeusz Warchol
  • Methods for synthesizing substituted tetracycline compounds
    Patent number: 9522872
    Abstract: Methods of synthesizing substituted tetracycline compounds are provided.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: December 20, 2016
    Assignee: PARATEK PHARMACEUTICALS, INC.
    Inventors: Farzaneh Seyedi, Tadeusz Warchol, Mark Grier
  • SALTS AND POLYMORPHS OF A TETRACYCLINE COMPOUND
    Publication number: 20160324879
    Abstract: Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general.
    Type: Application
    Filed: December 8, 2015
    Publication date: November 10, 2016
    Inventors: Raymond Cvetovich, Tadeusz Warchol
  • Methods for synthesizing and purifying aminoalkyl tetracycline compounds
    Patent number: 9434680
    Abstract: Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: September 6, 2016
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sean Johnston, Tadeusz Warchol
  • Salts and polymorphs of a tetracycline compound
    Patent number: 9227921
    Abstract: Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: January 5, 2016
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Raymond Cvetovich, Tadeusz Warchol
  • 9-SUBSTITUTED MINOCYCLINE COMPOUNDS
    Publication number: 20150265635
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: June 5, 2015
    Publication date: September 24, 2015
    Applicant: PARATEK PHARMACEUTICALS, INC.
    Inventors: Peter Viski, Beena Bhatia, Tadeusz Warchol, David Messersmith
  • 9-substituted minocycline compounds
    Patent number: 9090541
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: July 28, 2015
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Peter Viski, Beena Bhatia, Tadeusz Warchol, David Messersmith
  • Methods for synthesizing and purifying aminoalkyl tetracycline compounds
    Patent number: 8946196
    Abstract: Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: February 3, 2015
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Sean M. Johnston, Tadeusz Warchol
  • METHODS FOR SYNTHESIZING AND PURIFYING AMINOALKYL TETRACYCLINE COMPOUNDS
    Publication number: 20140031319
    Abstract: Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
    Type: Application
    Filed: September 30, 2013
    Publication date: January 30, 2014
    Applicant: PARATEK PHARMACEUTICALS, INC.
    Inventors: Sean M. Johnston, Tadeusz Warchol
  • 7-substituted tetracycline compounds
    Patent number: 8492365
    Abstract: The present invention pertains, at least in part, to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: June 9, 2009
    Date of Patent: July 23, 2013
    Assignees: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Ismail, Todd Bowser, Beena Bhatia, David Messersmith, Laura McIntyre, Darrell Koza, Glen Rennie, Paul Sheahan, Paul Hawkins, Atul Verma, Tadeusz Warchol, Upul Bandarage
  • Salts and polymorphs of 9-(2,2-dimethylpropyl-aminomethyl) minocycline
    Patent number: 8383610
    Abstract: Crystalline forms, including salts and polymorphs, of a compound useful in the treatment of tetracycline compound-responsive states are provided herein. The crystalline compounds are useful for the treatment or prevention of conditions and disorders such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds in general.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: February 26, 2013
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Raymond Cvetovich, Tadeusz Warchol
  • 9-SUBSTITUTED MINOCYCLINE COMPOUNDS
    Publication number: 20120283201
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: July 12, 2012
    Publication date: November 8, 2012
    Applicants: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell J. Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhalie, Atul K. Verma, Laura Honeyman, Tadeusz Warchol, David Messersmith
  • 9-substituted minocycline compounds
    Patent number: 8048867
    Abstract: The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: May 4, 2004
    Date of Patent: November 1, 2011
    Assignees: Trustees of Tufts College, Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Roger Frechette, Peter Viski, Mohamed Y. Ismail, Todd Bowser, Jimmy Dumornay, Glen Rennie, Gui Liu, Darrell J. Koza, Paul Sheahan, Karen Stapleton, Paul Hawkins, Beena Bhatia, Atul K. Verma, Laura McIntyre, Tadeusz Warchol, David Messersmith
  • TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20110230523
    Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.
    Type: Application
    Filed: August 6, 2009
    Publication date: September 22, 2011
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Stuart B. LEVY, Michael N. ALEKSHUN, Brent L. PODLOGAR, Kwasi OHEMENG, Atul K. VERMA, Tadeusz WARCHOL, Beena BHATIA, Todd BOWSER, Mark GRIER
  • Substituted Tetracycline Compounds
    Publication number: 20110086822
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Application
    Filed: October 8, 2010
    Publication date: April 14, 2011
    Inventors: Mark L. Nelson, Kwasi Ohemeng, Roger Frechette, Paul Abato, Victor Amoo, Upul Bandarage, Joel Berniac, Beena Bhatia, Jackson Chen, Mohamed Y. Ismail, Oak Kim, Laura Honeyman, Rachid Mechiche, Andre Pearson, Laxma Reddy Nagavelli, Paul Sheahan, Atul K. Verma, Peter Viski, Tadeusz Warchol
  • Substituted tetracycline compounds
    Patent number: 7820641
    Abstract: The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
    Type: Grant
    Filed: December 18, 2003
    Date of Patent: October 26, 2010
    Assignee: Paratek Pharmaceuticals, Inc.
    Inventors: Mark L. Nelson, Peter Viski, Jackson Chen, Tadeusz Warchol
  • METHODS FOR SYNTHESIZING AND PURIFYING AMINOALKYL TETRACYCLINE COMPOUNDS
    Publication number: 20100113401
    Abstract: Methods for the synthesis and purification of 9-amino alkyl tetracycline compounds are described.
    Type: Application
    Filed: October 29, 2009
    Publication date: May 6, 2010
    Applicant: Paratek Pharmaceuticals, Inc.
    Inventors: Sean Johnston, Tadeusz Warchol