Abstract: The present invention relates to a three-dimensional negative pressure stimulator module capable of performing customized composite stimulation for the improvement of skin functions that applies three-dimensional negative pressure stimulation as well as composite stimulation such as electric current stimulation, light stimulation, and thermal stimulation, which is helpful in improving functions of the skin, to skin compositively, and further has a function of sensing a skin state, thereby performing customized composite stimulation. The three-dimensional composite stimulator module includes: a negative pressure cup; and at least one diaphragm provided along the transmission path of the negative pressure of the negative pressure cup, wherein at least any one of negative pressure stimulation, light stimulation, thermal stimulation, and electrical stimulation is transmitted compositively to the skin or subcutaneous tissues.

Abstract: The present invention relates to a three-dimensional negative pressure stimulator module capable of performing customized composite stimulation for the improvement of skin functions that applies three-dimensional negative pressure stimulation as well as composite stimulation such as electric current stimulation, light stimulation, and thermal stimulation, which is helpful in improving functions of the skin, to skin compositively, and further has a function of sensing a skin state, thereby performing customized composite stimulation. The three-dimensional composite stimulator module includes: a negative pressure cup; and at least one diaphragm provided along the transmission path of the negative pressure of the negative pressure cup, wherein at least any one of negative pressure stimulation, light stimulation, thermal stimulation, and electrical stimulation is transmitted compositively to the skin or subcutaneous tissues.

Abstract: A use an extract of Coptidis Rhizoma or a combined extract of Coptidis Rhizoma and Pharbitidis Semen as an active ingredient for preventing and/or treating periodontal disease is provided. The extract of Coptidis Rhizoma or a combined extract of Coptidis Rhizoma and Pharbitidis Semen has activities to stimulate anti-inflammation, osteoblast differentiation and alveolar bone regeneration, and to prevent the alveolar bone destruction, thereby being effective for the prevention and/or treatment of periodontal disease.

Abstract: A use an extract of Coptidis Rhizoma or a combined extract of Coptidis Rhizoma and Pharbitidis Semen as an active ingredient for preventing and/or treating periodontal disease is provided. The extract of Coptidis Rhizoma or a combined extract of Coptidis Rhizoma and Pharbitidis Semen has activities to stimulate anti-inflammation, osteoblast differentiation and alveolar bone regeneration, and to prevent the alveolar bone destruction, thereby being effective for the prevention and/or treatment of periodontal disease.