Abstract: Microfluidic devices including a microfluidic channel with at least one surface having a plurality of chiral nanoparticles disposed thereon include a light-absorbing material (e.g., gold) and a targeting ligand capable of binding to a bioactive target analyte in a biological fluid sample. The bioactive target analyte can indicate presence of cancerous cells or mutated proteins in the biological fluid sample taken from a subject. Chiral gold nanoparticle layer-by-layer assembled onto a microfluidic device can rapidly isolate and profile cancer-associated exosomes directly from blood plasma using their own unique chiral signal. Exosomes from lung cancer patients can be distinguished from healthy donor exosomes by chiroptical spectroscopic signatures of biomolecular components. Mutation/deletion of epidermal growth factor receptor are also characterized, suggesting the possibility for in-depth mutation profiling in addition to cancer diagnostics.

Abstract: An emulsion spectrum fluid filter capable of controlling light wavelength absorption includes a transparent channel formed as a tube of a 90 degrees-rotated U shape, and an emulsion received in the transparent channel, wherein the emulsion may include dispersed oil and surfactant. Further, a method for preparing the emulsion is disclosed.

Abstract: Disclosed are embodiments of shortest path search in an obstacle environment. Provided is a shortest path search method including: creating an epsilon graph; and determining k closest points from a query point on the basis of the graph, wherein the creating of the graph includes: creating a node group of nodes on the basis of a point group of arrival points; creating an edge group of edges on the basis of the created nodes; setting, on the basis of an obstacle group of at least one obstacle, whether each of the nodes is a valid node or a non-valid node; setting, on the basis of the obstacle group, whether each of the edges is a valid or non-valid edge; and including, for each of the arrival points, a particular arrival point on an anchor list of a valid node closest from the particular arrival point among the valid nodes.

Abstract: A coil electronic component includes a main body; a coil embedded in the main body, an insulating layer disposed on one surface of the main body, a first conductive layer covering a portion of the one surface, a second conductive layer covering another portion of the one surface, and first and external electrodes respectively covering the first conductive layer. The coil electronic component has a first length L1 in a first direction, and a second length L2 is a sum of a third length L3 in the first direction of a region where the insulating layer, the first conductive layer, and the first external electrode overlap and a fourth length L4 in the first direction of a region where the insulating layer, the second conductive layer, and the second external electrode overlap. A ratio L2/L1 is 0.3 or more and 0.7 or less.

Abstract: Instruments, components thereof, consumables therefor, and associated methods are generally provided. Advantageously, some instruments described herein may be capable of performing and/or configured to perform assays at a rate that is faster and/or requires less input from an operator than assays performed by other methods. Some methods may comprise performing assays at such faster rates and/or involving such reduced input.

Abstract: The present invention relates to an efficient optimal facility location determination method for convex demand position demand points implemented to arrange a plurality of facilities as close as possible to given demand locations when positions of the demand locations satisfy a convex position condition. According to the efficient optimal facility location determination method for convex position demand points of the present invention, when demand locations satisfy a convex position condition, it is possible to quickly calculate a method of efficiently arranging a plurality of facilities in a very short time. In addition, according to the present invention, even if positions of demand locations do not satisfy a convex position condition, it is possible to approximate arrangement of facilities, and to be applied to various fields such as a location selection of a warehouse or data clustering.

Abstract: The present exemplary embodiments may provide a negative electrode material for a lithium secondary battery, the negative electrode material containing nano-silicon, crystalline carbon, amorphous carbon, and carbon nanotubes, wherein one end of the carbon nanotube is located inside the negative electrode material and the other end of the carbon nanotube protrudes out of the negative electrode material, and an average length of the carbon nanotubes protruding out of the negative electrode material is 0.1 ?m to 1 ?m.

Abstract: The present disclosure provides porous three dimensional polymeric devices useful for purifying and/or isolating a target cell-derived component (e.g., extracellular vesicles), and methods of making and systems or kits comprising thereof. Wherein the three-dimensional device is a cube that comprises a polymer, and wherein the polymer comprises polydimethylsiloxane (PDMS).

Abstract: A laser welding nozzle includes: a beam guide member allowing a laser beam to pass therethrough and having a diameter that decreases toward a lower end thereof, with a beam discharge port formed at the lower end to have a smallest diameter; and a housing coupled to the beam guide member in such a manner that an inner surface of the housing faces an outer surface of the beam guide member to form a shielding gas line outside the beam discharge port and form a suction line connected to the beam discharge port.

Abstract: Provided is an X-ray tube including a cathode structure, an anode spaced apart from the cathode structure, a spacer structure disposed between the cathode structure and the anode, and an external power supply connected to each of the cathode structure, the anode, and the spacer structure. Here, the spacer structure includes a first spacer disposed adjacent to the cathode structure and a second spacer disposed on the first spacer and disposed adjacent to the anode. The first spacer includes a first portion adjacent to the cathode structure and a second portion adjacent to a contact point of the first spacer and the second spacer. The second spacer includes a third portion adjacent to the contact point and a fourth portion adjacent to the anode. Each of the first portion and the third portion has a volume resistivity less than that of the second portion.

Abstract: A dehumidifying composition according to an embodiment of the present invention includes oil and a surfactant, wherein the oil and the surfactant may be mixed by at least one of mechanical stirring, ultrasonic stirring, ultrasonic grinding, or magnetic stirring.

Abstract: Instruments, components thereof, consumables therefor, and associated methods are generally provided. Advantageously, some instruments described herein may be capable of performing and/or configured to perform assays at a rate that is faster and/or requires less input from an operator than assays performed by other methods. Some methods may comprise performing assays at such faster rates and/or involving such reduced input.

Abstract: In some aspects, mutant or variant Fc domains are provided that exhibit increased binding to FcRn and increased half-life after administration in vivo. The Fc domain may be comprised in a glycosylated or aglycosylated antibody. Methods for using the mutant or variant Fc domains or polypeptides comprising the mutant or variant Fc domains are also provided.

Abstract: A display device includes an active area and a peripheral area adjacent to at least a portion of the active area; a base layer; a backplane layer disposed on the base layer; and a light-emitting-element layer disposed on the backplane layer, and including a light emitting element. The backplane layer includes a lower backplane layer, an outer via layer disposed on the lower backplane layer, and an outer passivation layer disposed on the outer via layer. The outer passivation layer includes a first outer passivation layer exposing the outer via layer through a hole in the active area, and a second outer passivation layer not exposing the outer via layer in the peripheral area.

Abstract: Provided are an electronic device for removing an advertisement thumbnail from a display screen for providing a list of sports and an operating method of the electronic device that may retrieve an image thumbnail extracted from a game video being broadcast live, determine whether the image thumbnail is a game thumbnail or an advertisement thumbnail using a pre-trained deep learning model, and display the game thumbnail on a display screen when the image thumbnail is the game thumbnail and remove the advertisement thumbnail on the display screen when the image thumbnail is the advertisement thumbnail.

Abstract: The present invention relates to a multifunctional exercise equipment designed to allow a user to select and do various exercises, such as Pilates, fitness, and aerobic exercise, at low cost without the need for a large space at home or in the office.

Abstract: The present invention relates to a naphthalimide sulfonate derivative, and a photoacid generator and a photoresist composition each comprising same and, more specifically, to a naphthalimide sulfonate derivative compound, and a photoacid generator and a photoresist composition each comprising same, wherein the compound has excellent absorbance for light of i-line (365 nm) wavelength, is greatly easy to prepare into a polymerizable composition due to very high solubility in an organic solvent, has good thermal stability, and shows a favorable acid generation rate.

Abstract: The present invention relates to an oncolytic virus and the use thereof, specifically, an oncolytic virus having suppressed thymidine kinase (TK) gene expression and comprising genes encoding granulocyte-macrophage colony-stimulating factor (GM-CSF) and a complement regulatory protein; and the use of such an oncolytic virus. The oncolytic virus of the present invention maintains its efficacy even when administered intravenously, and thus, it may also be applied to the treatment of various solid cancers and metastatic cancers in addition to superficial solid cancers. In addition, the oncolytic virus of the present invention acquires resistance to complement attack by expressing a complement regulatory protein on the surface of the virus, and thus, it is stable in the blood, and it maintains stable oncolytic activity when intravenous injection, and thus, it may reduce effective viral dosage to minimize the side effects of anti-cancer drugs.

Abstract: The present embodiments relate to a negative electrode active material for a lithium secondary battery, a method for preparing the same, and a lithium secondary battery comprising the same. The negative electrode active material for a lithium secondary battery, according to one embodiment, comprises a silicon-carbon composite comprising silicon nanoparticles and a carbon matrix, and can have a degree of oxidation that is less than or equal to 10.5%.

Abstract: Provided is a high voltage driving device including a housing and a cathode, an anode, and an insulation structure, which are disposed in the housing. Here, the cathode and the anode are spaced apart from each other with the insulation structure therebetween. Also, the insulation structure includes a first solid insulator disposed adjacent to the cathode and a second solid insulator disposed adjacent to the anode. Also, the first solid insulator has first volumetric resistivity less than second volumetric resistivity of the second solid insulator, and the first solid insulator contacts the cathode.