Abstract: The present disclosure relates to an isolated anti-FcRN antibody, which is an antibody binding to FcRN (stands for neonatal Fc receptor, also called FcRP, FcRB or Brambell receptor) that is a receptor with a high affinity for IgG or a fragment thereof, a method of preparing thereof, a composition for treating autoimmune disease, which comprises the antibody, and a method of treating and diagnosing autoimmunre diseases using the antibody. The FcRn-specific antibody according to the present disclosure binds to FcRn non-competitively with IgG to reduce serum pathogenic auto-antibody levels, and thus can be used for the treatment of autoimmune diseases.

Abstract: A retractable outside door handle assembly has a handle unit including an outside handle having a pushing portion and mounted on a handle housing. The outside handle is configured to protrude by rotating in a first direction. An actuator includes an operation rod configured to selectively push the pushing portion. A door latch lever is rotatably mounted on the handle housing and configured to rotate during protrusion of the outside handle by operation of the actuator. A damage prevention mechanism is located between the operation rod and the pushing portion and configured to push the pushing portion when the actuator is operated. The damage prevention mechanism is configured to prevent a pushing force of the pushing portion from being transmitted to the operation rod when the outside handle rotates in a second direction opposite the first direction in a protruded state.

Abstract: An embodiment retractable outside door handle assembly includes a handle unit including an outside handle having a pushing portion and mounted on a handle housing, wherein the outside handle is configured to protrude by rotating in a first direction, an actuator including an operation rod configured to selectively push the pushing portion, a door latch lever rotatably mounted on the handle housing and configured to rotate during protrusion of the outside handle by operation of the actuator, and a damage prevention mechanism between the operation rod and the pushing portion and configured to push the pushing portion when the actuator is operated, wherein the damage prevention mechanism is configured to prevent a pushing force of the pushing portion from being transmitted to the operation rod when the outside handle rotates in a second direction opposite the first direction in a protruded state.